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Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor

Antimicrobial Agents and Chemotherapy, 1997-05, Vol.41 (5), p.1058-1063

1997

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An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Proceedings of the National Academy of Sciences - PNAS, 1990-10, Vol.87 (19), p.7472-7476

1990

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The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors

The Journal of biological chemistry, 1993-06, Vol.268 (18), p.13103-13109

1993

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Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling

Protein science, 1992-08, Vol.1 (8), p.1061-1072

1992

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Effects of U-75875, a peptidomimetic inhibitor of retroviral proteases, on simian immunodeficiency virus infection in rhesus monkeys

Antimicrobial Agents and Chemotherapy, 1994-06, Vol.38 (6), p.1277-1283

1994

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An Orally Active Inhibitor of Renin

Hypertension (Dallas, Tex. 1979), 1986-12, Vol.8 (12), p.1105-1112

1986

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Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages

The Journal of infectious diseases, 1993-11, Vol.168 (5), p.1148-1156

1993

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Structure-based discovery of tipranavir disodium (PNU-140690E): A potent, orally bioavailable, nonpeptidic HIV protease inhibitor

BIOPOLYM, 1999, Vol.51 (1), p.51-58

1999

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Factors impacting the delivery of therapeutic levels of pyrone-based HIV protease inhibitors

Pharmaceutical biotechnology, 1998, Vol.11, p.211

1998

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Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Journal of medicinal chemistry, 1996-06, Vol.39 (12), p.2400-2410

1996

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Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors

Journal of medicinal chemistry, 1996-10, Vol.39 (22), p.4349-4353

1996

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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3624-3637

1995

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Effect of Point Mutations on the Kinetics and the Inhibition of Human Immunodeficiency Virus Type 1 Protease: Relationship to Drug Resistance

Biochemistry (Easton), 1995, Vol.34 (4), p.1143-1152

1995

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Kinetics of the inhibition of human renin by an inhibitor containing a hydroxyethylene dipeptide isostere

Biochemistry (Easton), 1987-12, Vol.26 (24), p.7621-7626

1987

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An efficient method for the preparation of furanoid and pyranoid glycals

Journal of organic chemistry, 1978-02, Vol.43 (4), p.786-787

1978

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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors

Journal of medicinal chemistry, 1994-09, Vol.37 (20), p.3200-3204

1994

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Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

Journal of medicinal chemistry, 1996-11, Vol.39 (23), p.4630-4642

1996

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Diastereoselective benzyloxymercuration/demercuration of derivatives of γ-alkyl-δ-hydroxy-α,β-unsaturated esters. A new strategy for the synthesis of aldol-type products

Journal of the American Chemical Society, 1983, Vol.105 (25), p.7407-7413

1983

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Non-peptidic HIV protease inhibitors: C 2-symmetry-based design of bis-sulfonamide dihydropyrones

Bioorganic & medicinal chemistry letters, 1998-05, Vol.8 (10), p.1237-1242

1998

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Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones

Bioorganic & medicinal chemistry letters, 1998-05, Vol.8 (10), p.1237-1242

1998

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Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogs

Journal of medicinal chemistry, 1986-10, Vol.29 (10), p.2080-2087

1986

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An approach to the total synthesis of aplysiatoxin

Journal of the American Chemical Society, 1988-08, Vol.110 (17), p.5768-5779

1988

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Potential HIV protease inhibitors: Preparation of di- N-alkylated 2-, 6-, and 2,6-aminodeoxy-derivatives of d-glucose by direct displacement and by a novel reductive-alkylation procedure

Carbohydrate research, 1997-05, Vol.300 (2), p.109-117

1997

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alpha.,.alpha.-Difluoro-.beta.-aminodeoxystatine-containing renin-inhibitory peptides

Journal of medicinal chemistry, 1987-10, Vol.30 (10), p.1837-1842

1987

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The total synthesis of ionophore antibiotics. A convergent synthesis of lasalocid A (X537A)

Journal of the American Chemical Society, 1983-04, Vol.105 (7), p.1988-2006

1983

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Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor

An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors

Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling

Effects of U-75875, a peptidomimetic inhibitor of retroviral proteases, on simian immunodeficiency virus infection in rhesus monkeys

An Orally Active Inhibitor of Renin

Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages

Structure-based discovery of tipranavir disodium (PNU-140690E): A potent, orally bioavailable, nonpeptidic HIV protease inhibitor

Factors impacting the delivery of therapeutic levels of pyrone-based HIV protease inhibitors

Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors

Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Effect of Point Mutations on the Kinetics and the Inhibition of Human Immunodeficiency Virus Type 1 Protease: Relationship to Drug Resistance

Kinetics of the inhibition of human renin by an inhibitor containing a hydroxyethylene dipeptide isostere

An efficient method for the preparation of furanoid and pyranoid glycals

Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors

Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

Diastereoselective benzyloxymercuration/demercuration of derivatives of γ-alkyl-δ-hydroxy-α,β-unsaturated esters. A new strategy for the synthesis of aldol-type products

Non-peptidic HIV protease inhibitors: C 2-symmetry-based design of bis-sulfonamide dihydropyrones

Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones

Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogs

An approach to the total synthesis of aplysiatoxin

Potential HIV protease inhibitors: Preparation of di- N-alkylated 2-, 6-, and 2,6-aminodeoxy-derivatives of d-glucose by direct displacement and by a novel reductive-alkylation procedure

alpha.,.alpha.-Difluoro-.beta.-aminodeoxystatine-containing renin-inhibitory peptides

The total synthesis of ionophore antibiotics. A convergent synthesis of lasalocid A (X537A)

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