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Contribution of late sodium current (INa-L ) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents

Heart rhythm, 2011-05, Vol.8 (5), p.762-769

2011

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Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: A blinded validation

Heart rhythm, 2012-10, Vol.9 (10), p.1706-1715

2012

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Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome: Direct evidence from intracellular recordings in the intact left ventricular wall

Circulation (New York, N.Y.), 2001-06, Vol.103 (23), p.2851-2856

2001

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Ventricular hypertrophy amplifies transmural dispersion of repolarization by preferentially increasing the late sodium current in endocardium

Journal of electrocardiology, 2014-09, Vol.47 (5), p.642-648

2014

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Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit

American journal of physiology. Heart and circulatory physiology, 2008-07, Vol.295 (1), p.H97-H104

2008

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Abstract 14031: Effects of Custodiol-HTK and Del Nido Solutions in a Coronary-Perfused Rabbit Ventricular Wedge Model

Circulation (New York, N.Y.), 2021-11, Vol.144 (Suppl_1)

2021

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Utility of Normalized TdP Score System in Drug Proarrhythmic Potential Assessment: A Blinded in vitro Study of CiPA Drugs

Clinical pharmacology and therapeutics, 2021-06, Vol.109 (6), p.1606-1617

2021

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L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species

Heart rhythm, 2008-02, Vol.5 (2), p.271-279

2008

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Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits

Circulation (New York, N.Y.), 2001-03, Vol.103 (11), p.1585-1590

2001

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Increasing I Ks corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy

American journal of physiology. Heart and circulatory physiology, 2002-08, Vol.283 (2), p.H664-H670

2002

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GW29-e1186 Determination of Electrophysiological Effects and Cardiac Safety of Three Chinese Herb Monomers by Using the Isolated Rabbit Ventricular Wedge Model

Journal of the American College of Cardiology, 2018-10, Vol.72 (16), p.C36-C36

2018

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How to determine cardiac ion channels targeted by drugs using the isolated rabbit ventricular wedge model

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.161-170

2016

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Wenxin Keli Suppresses Ventricular Triggered Arrhythmias via Selective Inhibition of Late Sodium Current

Pacing and clinical electrophysiology, 2013-06, Vol.36 (6), p.732-740

2013

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Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias

Heart rhythm, 2006-08, Vol.3 (8), p.948-956

2006

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Electrophysiological Properties of HBI-3000: A New Antiarrhythmic Agent With Multiple-channel Blocking Properties in Human Ventricular Myocytes

Journal of cardiovascular pharmacology, 2011-01, Vol.57 (1), p.79-85

2011

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L-Type Calcium Current Reactivation Contributes to Arrhythmogenesis Associated with Action Potential Triangulation

Journal of cardiovascular electrophysiology, 2007-02, Vol.18 (2), p.196-203

2007

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Electrophysiologic Effects of SB-237376: A New Antiarrhythmic Compound with Dual Potassium and Calcium Channel Blocking Action

Journal of cardiovascular pharmacology, 2003-03, Vol.41 (3), p.414-421

2003

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REVERSE-USE DEPENDENCE OF ANTIARRHYTHMIC DRUGS: ROLE OF LATE SODIUM CURRENT

Journal of the American College of Cardiology, 2011-04, Vol.57 (14), p.E2014-E2014

2011

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Restoration of Normal Ventricular Electrophysiology in Renovascular Hypertensive Rabbits after Treatment with Losartan

Journal of cardiovascular pharmacology, 2001-03, Vol.37 (3), p.317-323

2001

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Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization

American journal of physiology. Heart and circulatory physiology, 2001-11, Vol.50 (5), p.H1968-H1975

2001

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Differentiating electrophysiological effects and cardiac safety of drugs based on in vitro electrocardiogram: A blinded validation

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.e23-e23

2013

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Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization

American journal of physiology. Heart and circulatory physiology, 2001-11, Vol.281 (5), p.H1968-H1975

2001

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Assessment of the Proarrhythmic Potential of the Novel Antiarrhythmic Agent AZD7009 and Dofetilide in Experimental Models of Torsades De Pointes

Journal of cardiovascular electrophysiology, 2005-08, Vol.16 (8), p.898-904

2005

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Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit

American journal of physiology. Heart and circulatory physiology, 2008, Vol.64 (1)

2008

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Increasing IKs corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy

American journal of physiology. Heart and circulatory physiology, 2002-08, Vol.283 (2), p.H664

2002

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Contribution of late sodium current (INa-L ) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents

Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: A blinded validation

Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome: Direct evidence from intracellular recordings in the intact left ventricular wall

Ventricular hypertrophy amplifies transmural dispersion of repolarization by preferentially increasing the late sodium current in endocardium

Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit

Abstract 14031: Effects of Custodiol-HTK and Del Nido Solutions in a Coronary-Perfused Rabbit Ventricular Wedge Model

Utility of Normalized TdP Score System in Drug Proarrhythmic Potential Assessment: A Blinded in vitro Study of CiPA Drugs

L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species

Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits

Increasing I Ks corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy

GW29-e1186 Determination of Electrophysiological Effects and Cardiac Safety of Three Chinese Herb Monomers by Using the Isolated Rabbit Ventricular Wedge Model

How to determine cardiac ion channels targeted by drugs using the isolated rabbit ventricular wedge model

Wenxin Keli Suppresses Ventricular Triggered Arrhythmias via Selective Inhibition of Late Sodium Current

Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias

Electrophysiological Properties of HBI-3000: A New Antiarrhythmic Agent With Multiple-channel Blocking Properties in Human Ventricular Myocytes

L-Type Calcium Current Reactivation Contributes to Arrhythmogenesis Associated with Action Potential Triangulation

Electrophysiologic Effects of SB-237376: A New Antiarrhythmic Compound with Dual Potassium and Calcium Channel Blocking Action

REVERSE-USE DEPENDENCE OF ANTIARRHYTHMIC DRUGS: ROLE OF LATE SODIUM CURRENT

Restoration of Normal Ventricular Electrophysiology in Renovascular Hypertensive Rabbits after Treatment with Losartan

Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization

Differentiating electrophysiological effects and cardiac safety of drugs based on in vitro electrocardiogram: A blinded validation

Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization

Assessment of the Proarrhythmic Potential of the Novel Antiarrhythmic Agent AZD7009 and Dofetilide in Experimental Models of Torsades De Pointes

Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit

Increasing IKs corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy

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