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Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs

Anti-cancer drug design, 1995-06, Vol.10 (4), p.299

1995

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Antimitotic agents: structure-activity studies with some pyridine derivatives

Journal of medicinal chemistry, 1992-10, Vol.35 (20), p.3686-3690

1992

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Antimitotic agents. Synthesis of imidazo[4,5-c]pyridin-6-ylcarbamates and imidazo[4,5-b]pyridin-5-ylcarbamates

Journal of medicinal chemistry, 1990-02, Vol.33 (2), p.656-661

Temple, Carroll

1990

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Tubulin binding of two 1-deaza-7,8-dihydropteridines with different biological properties: Enantiomers NSC 613862 (S)-(-) and NSC 613863 (R)-(+)

Biochemistry (Easton), 1993-10, Vol.32 (40), p.10675-10682

1993

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Antimitotic agents: ring analogs and derivatives of ethyl [(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl]carbamate

Journal of medicinal chemistry, 1992-12, Vol.35 (26), p.4809-4812

1992

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Synthesis of potential anticancer agents: imidazo[4,5-c]pyridines and imidazo[4,5-b]pyridines

Journal of medicinal chemistry, 1987-10, Vol.30 (10), p.1746-1751

1987

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Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4-hydroxyphenyl)2-methylpyrido[3,4-b]pyrazin-7-yl]carbamate

Journal of medicinal chemistry, 1992-03, Vol.35 (6), p.988-993

1992

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Potential antimitotic agents. Synthesis of some ethyl benzopyrazin-7-ylcarbamates, ethyl pyrido[3,4-b]pyrazin-7-ylcarbamates, and ethyl pyrido[3,4-e]-as-triazin-7-ylcarbamates

Journal of medicinal chemistry, 1990-11, Vol.33 (11), p.3044-3050

1990

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Comparison of 1,2-dihydropyrido[3,4-b]pyrazines (1-deaza-7,8-dihydropteridines) with several other inhibitors of mitosis

Cancer research (Chicago, Ill.), 1987-03, Vol.47 (6), p.1621-1626

1987

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Pharmacokinetic and metabolism studies of two novel 1-deaza-7,8-dihydropteridines in mice

Drug metabolism and disposition, 1985-11, Vol.13 (6), p.677

1985

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Potential anticancer agents. 5-(N-Substituted-aminocarbonyl)- and 5-(N-substituted-aminothiocarbonyl)-5,6,7,8-tetrahydrofolic acids

Journal of medicinal chemistry, 1988-03, Vol.31 (3), p.697-700

1988

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Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 613863

Cancer research (Chicago, Ill.), 1994-01, Vol.54 (1), p.75-84

1994

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Biological effects and structure-activity relationships of 1,2-dihydropyrido[3,4-b]pyrazines

Cancer research (Chicago, Ill.), 1983-08, Vol.43 (8), p.3567-3575

1983

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Synthesis of potential anticancer agents. Pyrido[4,3-b][1,4]oxazines and pyrido[4,3-b][1,4]thiazines

Journal of medicinal chemistry, 1983-11, Vol.26 (11), p.1614-1619

1983

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Optimum Scheduling during combination chemotherapy of murine leukemia. Additional examples of Schedule-dependent synergism between S-phase-specific antimetabolites and agents inducing mitotic of pre-mitotic (G2) arrest

Cancer chemotherapy and pharmacology, 1983, Vol.11 (3), p.205-207

1983

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New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-carbamate

Journal of medicinal chemistry, 1989-09, Vol.32 (9), p.2089-2092

1989

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New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-car bamate

Journal of medicinal chemistry, 1989-09, Vol.32 (9), p.2089

1989

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Molecular interaction of tubulin with 1-deaza-7,8-dihydropteridines: a comparative study of enantiomers NSC 613862 (S) and NSC 613863 (R) by Raman and Fourier transform infrared spectroscopy

International journal of biological macromolecules, 1995-02, Vol.17 (1), p.55-60

1995

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Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 61363

Cancer research (Chicago, Ill.), 1994, Vol.54 (1), p.75-84

1994

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New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamates

Journal of medicinal chemistry, 1989-10, Vol.32 (10), p.2363-2367

1989

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New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)car bamates

Journal of medicinal chemistry, 1989-10, Vol.32 (10), p.2363-2367

1989

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Antitumor drug cross-resistance in vivo in a murine P388 leukemia resistant to ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate 2-hydroxyethanesulfonate hydrate (NSC 370147) 370147

Cancer chemotherapy and pharmacology, 1992, Vol.29 (3), p.190-194

1992

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Tubulin binding properties of two chiral isomers with 1-deaza-7,8-dihydropteridine structure

Advances in experimental medicine and biology, 1993, Vol.338, p.465

1993

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Protonated state of methotrexate, trimethoprim, and pyrimethamine bound to dihydrofolate reductase

Archives of biochemistry and biophysics, 1983-10, Vol.226 (2), p.567-577

1983

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Antitumor activity of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenyl-pyrido[3,4-b]pyrazin-7-ylcarbamate, 2-hydroxyethanesulfonate, hydrate (NSC 370147) against selected tumor systems in culture and in mice

Cancer research (Chicago, Ill.), 1990-06, Vol.50 (11), p.3239-3244

1990

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Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs

Antimitotic agents: structure-activity studies with some pyridine derivatives

Antimitotic agents. Synthesis of imidazo[4,5-c]pyridin-6-ylcarbamates and imidazo[4,5-b]pyridin-5-ylcarbamates

Tubulin binding of two 1-deaza-7,8-dihydropteridines with different biological properties: Enantiomers NSC 613862 (S)-(-) and NSC 613863 (R)-(+)

Antimitotic agents: ring analogs and derivatives of ethyl [(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl]carbamate

Synthesis of potential anticancer agents: imidazo[4,5-c]pyridines and imidazo[4,5-b]pyridines

Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4-hydroxyphenyl)2-methylpyrido[3,4-b]pyrazin-7-yl]carbamate

Potential antimitotic agents. Synthesis of some ethyl benzopyrazin-7-ylcarbamates, ethyl pyrido[3,4-b]pyrazin-7-ylcarbamates, and ethyl pyrido[3,4-e]-as-triazin-7-ylcarbamates

Comparison of 1,2-dihydropyrido[3,4-b]pyrazines (1-deaza-7,8-dihydropteridines) with several other inhibitors of mitosis

Pharmacokinetic and metabolism studies of two novel 1-deaza-7,8-dihydropteridines in mice

Potential anticancer agents. 5-(N-Substituted-aminocarbonyl)- and 5-(N-substituted-aminothiocarbonyl)-5,6,7,8-tetrahydrofolic acids

Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 613863

Biological effects and structure-activity relationships of 1,2-dihydropyrido[3,4-b]pyrazines

Synthesis of potential anticancer agents. Pyrido[4,3-b][1,4]oxazines and pyrido[4,3-b][1,4]thiazines

Optimum Scheduling during combination chemotherapy of murine leukemia. Additional examples of Schedule-dependent synergism between S-phase-specific antimetabolites and agents inducing mitotic of pre-mitotic (G2) arrest

New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-carbamate

New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-car bamate

Molecular interaction of tubulin with 1-deaza-7,8-dihydropteridines: a comparative study of enantiomers NSC 613862 (S) and NSC 613863 (R) by Raman and Fourier transform infrared spectroscopy

Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 61363

New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamates

New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)car bamates

Antitumor drug cross-resistance in vivo in a murine P388 leukemia resistant to ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate 2-hydroxyethanesulfonate hydrate (NSC 370147) 370147

Tubulin binding properties of two chiral isomers with 1-deaza-7,8-dihydropteridine structure

Protonated state of methotrexate, trimethoprim, and pyrimethamine bound to dihydrofolate reductase

Antitumor activity of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenyl-pyrido[3,4-b]pyrazin-7-ylcarbamate, 2-hydroxyethanesulfonate, hydrate (NSC 370147) against selected tumor systems in culture and in mice

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