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Synergy of Mutation-Induced Effects in Human Vitamin K Epoxide Reductase: Perspectives and Challenges for Allo-Network Modulator Design

International journal of molecular sciences, 2024-02, Vol.25 (4), p.2043

2024

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Does Generic Cyclic Kinase Insert Domain of Receptor Tyrosine Kinase KIT Clone Its Native Homologue?

International journal of molecular sciences, 2022-11, Vol.23 (21), p.12898

2022

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Vitamin K Epoxide Reductase Complex-Protein Disulphide Isomerase Assemblies in the Thiol-Disulphide Exchange Reactions: Portrayal of Precursor-to-Successor Complexes

International journal of molecular sciences, 2024-04, Vol.25 (8), p.4135

2024

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Folding and Intrinsic Disorder of the Receptor Tyrosine Kinase KIT Insert Domain Seen by Conventional Molecular Dynamics Simulations

International journal of molecular sciences, 2021-07, Vol.22 (14), p.7375

2021

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The Inherent Coupling of Intrinsically Disordered Regions in the Multidomain Receptor Tyrosine Kinase KIT

International journal of molecular sciences, 2022-01, Vol.23 (3), p.1589

2022

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Human Vitamin K Epoxide Reductase as a Target of Its Redox Protein

International journal of molecular sciences, 2022-03, Vol.23 (7), p.3899

2022

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Allosteric communication across the native and mutated KIT receptor tyrosine kinase

PLoS computational biology, 2012-08, Vol.8 (8), p.e1002661

2012

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How does binding of agonist ligands control intrinsic molecular dynamics in human NMDA receptors?

PloS one, 2018-08, Vol.13 (8), p.e0201234-e0201234

2018

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Identification of the Primary Factors Determining the Specificity of Human VKORC1 Recognition by Thioredoxin-Fold Proteins

International journal of molecular sciences, 2021-01, Vol.22 (2), p.802

2021

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The First 3D Model of the Full-Length KIT Cytoplasmic Domain Reveals a New Look for an Old Receptor

Scientific reports, 2020-03, Vol.10 (1), p.5401-5401, Article 5401

2020

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Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

Antimicrobial Agents and Chemotherapy, 2008-04, Vol.52 (4), p.1351-1358

2008

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Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy

Haematologica (Roma), 2014-03, Vol.99 (3), p.417-429

2014

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Mutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanisms

PLoS computational biology, 2011-06, Vol.7 (6), p.e1002068-e1002068

2011

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Hotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivity

PLoS computational biology, 2014-07, Vol.10 (7), p.e1003749-e1003749

2014

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How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5

PloS one, 2015-12, Vol.10 (12), p.e0145142-e0145142

2015

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Differential effects of CSF-1R D802V and KIT D816V homologous mutations on receptor tertiary structure and allosteric communication

PloS one, 2014-05, Vol.9 (5), p.e97519-e97519

2014

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Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis

Cancer research (Chicago, Ill.), 2014-11, Vol.74 (22), p.6554-6564

2014

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Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo

Antimicrobial Agents and Chemotherapy, 2010-01, Vol.54 (1), p.491-501

2010

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Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT

PloS one, 2016-07, Vol.11 (7), p.e0160165-e0160165

2016

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Raltegravir: molecular basis of its mechanism of action

European journal of medical research, 2009-11, Vol.14 Suppl 3 (Suppl 3), p.5-16

2009

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Site-Specific Phosphorylation of RTK KIT Kinase Insert Domain: Interactome Landscape Perspectives

Kinases and Phosphatases, 2023-03, Vol.1 (1), p.39-71

2023

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Receptor Tyrosine Kinase KIT: A New Look for an Old Receptor

Bioinformatics and Biomedical Engineering, p.133-137

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Receptor Tyrosine Kinase KIT: Mutation-Induced Conformational Shift Promotes Alternative Allosteric Pockets

Kinases and Phosphatases, 2023-09, Vol.1 (4), p.220-250

2023

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A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets

Global Journal of Cancer Therapy, 2022-10, Vol.8 (1), p.36-39

2022

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HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

Nature (London), 2014-10, Vol.514 (7521), p.242-246

2014

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Synergy of Mutation-Induced Effects in Human Vitamin K Epoxide Reductase: Perspectives and Challenges for Allo-Network Modulator Design

Does Generic Cyclic Kinase Insert Domain of Receptor Tyrosine Kinase KIT Clone Its Native Homologue?

Vitamin K Epoxide Reductase Complex-Protein Disulphide Isomerase Assemblies in the Thiol-Disulphide Exchange Reactions: Portrayal of Precursor-to-Successor Complexes

Folding and Intrinsic Disorder of the Receptor Tyrosine Kinase KIT Insert Domain Seen by Conventional Molecular Dynamics Simulations

The Inherent Coupling of Intrinsically Disordered Regions in the Multidomain Receptor Tyrosine Kinase KIT

Human Vitamin K Epoxide Reductase as a Target of Its Redox Protein

Allosteric communication across the native and mutated KIT receptor tyrosine kinase

How does binding of agonist ligands control intrinsic molecular dynamics in human NMDA receptors?

Identification of the Primary Factors Determining the Specificity of Human VKORC1 Recognition by Thioredoxin-Fold Proteins

The First 3D Model of the Full-Length KIT Cytoplasmic Domain Reveals a New Look for an Old Receptor

Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy

Mutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanisms

Hotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivity

How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5

Differential effects of CSF-1R D802V and KIT D816V homologous mutations on receptor tertiary structure and allosteric communication

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis

Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo

Insight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KIT

Raltegravir: molecular basis of its mechanism of action

Site-Specific Phosphorylation of RTK KIT Kinase Insert Domain: Interactome Landscape Perspectives

Receptor Tyrosine Kinase KIT: A New Look for an Old Receptor

Receptor Tyrosine Kinase KIT: Mutation-Induced Conformational Shift Promotes Alternative Allosteric Pockets

A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets

HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

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