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Antidepressant-Like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis

Proceedings of the National Academy of Sciences - PNAS, 2005-12, Vol.102 (51), p.18620-18625

2005

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An endocannabinoid mechanism for stress-induced analgesia

Nature, 2005-06, Vol.435 (7045), p.1108-1112

2005

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Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.352

2005

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Modulation of anxiety through blockade of anandamide hydrolysis

Nature medicine, 2003-01, Vol.9 (1), p.76-81

2003

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Cyclohexylcarbamic Acid 3‘- or 4‘-Substituted Biphenyl-3-yl Esters as Fatty Acid Amide Hydrolase Inhibitors: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling Studies

Journal of medicinal chemistry, 2004-10, Vol.47 (21), p.4998-5008

2004

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2-N-Acylaminoalkylindoles: Design and Quantitative Structure−Activity Relationship Studies Leading to MT2-Selective Melatonin Antagonists

Journal of medicinal chemistry, 2001-08, Vol.44 (18), p.2900-2912

2001

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Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

Nature, 2003-09, Vol.425 (6953), p.90-93

2003

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Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

Nature neuroscience, 2005-09, Vol.8 (9), p.1139-1141

2005

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Design, Synthesis, and Structure−Activity Relationships of Alkylcarbamic Acid Aryl Esters, a New Class of Fatty Acid Amide Hydrolase Inhibitors

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2352-2360

2003

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Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes

Toxicology and applied pharmacology, 2009-08, Vol.239 (1), p.37-45

2009

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Analysis of Structure−Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models

Journal of medicinal chemistry, 2005-06, Vol.48 (12), p.4049-4060

2005

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QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation

Chemical communications (Cambridge, England), 2005-09 (35), p.4399-4401

2005

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Mimosine induces apoptosis in the HL60 human tumor cell line

Apoptosis (London), 1999-12, Vol.4 (6), p.469-477

1999

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Melatonin prevents apoptosis induced by UV-B treatment in U937 cell line

Journal of pineal research, 2006-03, Vol.40 (2), p.158-167

2006

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Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism

Biochemical journal, 2002-05, Vol.364 (Pt 1), p.121-128

2002

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Reassessing the melatonin pharmacophore—Enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue

Bioorganic & medicinal chemistry, 2006-05, Vol.14 (10), p.3383-3391

2006

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Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters

Journal of mass spectrometry, 2004-12, Vol.39 (12), p.1450-1455

2004

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Three-Dimensional Quantitative Structure−Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation

Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1429-1439

2003

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collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity

Journal of mass spectrometry., 2009-04, Vol.44 (4), p.561-565

2009

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Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity

Journal of pineal research, 2006-04, Vol.40 (3), p.259-269

2006

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Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-n-oxide as selective glycine antagonists

Bioorganic & medicinal chemistry letters, 1996-11, Vol.6 (22), p.2749-2754

1996

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Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities

Journal of pineal research, 2004-03, Vol.36 (2), p.95-102

2004

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Synthesis of 1-(isoxazol-3-yl)triazene derivatives. Antimetastatic activity of 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene

European journal of medicinal chemistry, 1996, Vol.31 (9), p.735-740

1996

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Synthesis and structure–activity relationships of a series of pyrrole cannabinoid receptor agonists

Bioorganic & medicinal chemistry, 2003-09, Vol.11 (18), p.3965-3973

2003

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Melatonin

Current medicinal chemistry, 1999-06, Vol.6 (6), p.501

1999

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Antidepressant-Like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis

An endocannabinoid mechanism for stress-induced analgesia

Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation

Modulation of anxiety through blockade of anandamide hydrolysis

Cyclohexylcarbamic Acid 3‘- or 4‘-Substituted Biphenyl-3-yl Esters as Fatty Acid Amide Hydrolase Inhibitors: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling Studies

2-N-Acylaminoalkylindoles: Design and Quantitative Structure−Activity Relationship Studies Leading to MT2-Selective Melatonin Antagonists

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

Design, Synthesis, and Structure−Activity Relationships of Alkylcarbamic Acid Aryl Esters, a New Class of Fatty Acid Amide Hydrolase Inhibitors

Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes

Analysis of Structure−Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models

QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation

Mimosine induces apoptosis in the HL60 human tumor cell line

Melatonin prevents apoptosis induced by UV-B treatment in U937 cell line

Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism

Reassessing the melatonin pharmacophore—Enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue

Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters

Three-Dimensional Quantitative Structure−Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands: Requirements for Subtype Selectivity and Intrinsic Activity Modulation

collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity

Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity

Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-n-oxide as selective glycine antagonists

Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities

Synthesis of 1-(isoxazol-3-yl)triazene derivatives. Antimetastatic activity of 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene

Synthesis and structure–activity relationships of a series of pyrrole cannabinoid receptor agonists

Melatonin

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