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High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds

Current opinion in chemical biology, 1998-06, Vol.2 (3), p.411-416

1998

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The emerging importance of predictive ADME simulation in drug discovery

Drug Discovery Today, 2002-01, Vol.7 (2), p.109-116

2002

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Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans

Drug metabolism and disposition, 1995-11, Vol.23 (11), p.1225

1995

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Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate

Chemico-biological interactions, 1998-10, Vol.115 (3), p.175-199

1998

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Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6 substrate metabolism

Xenobiotica, 1997-04, Vol.27 (4), p.319-339

1997

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Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity

Toxicology (Amsterdam), 1999-03, Vol.133 (1), p.1-33

1999

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Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans

Antimicrobial Agents and Chemotherapy, 1985-11, Vol.28 (5), p.648-653

1985

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Molecular modelling of CYP3A4 from an alignment with CYP102: Identification of key interactions between putative active site residues and CYP3A-specific chemicals

Xenobiotica, 1996-10, Vol.26 (10), p.1067-1086

1996

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Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102

Toxicology (Amsterdam), 1999-11, Vol.139 (1), p.53-79

1999

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Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform

Xenobiotica, 2000, Vol.30 (1), p.1-25

2000

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Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily

Xenobiotica, 1998-03, Vol.28 (3), p.235-268

1998

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Correction of acidosis in hemodialysis patients increases the sensitivity of the parathyroid glands to calcium

Journal of the American Society of Nephrology, 1997-04, Vol.8 (4), p.627-631

1997

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Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver

Biochemical pharmacology, 1994-03, Vol.47 (7), p.1253-1257

1994

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Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4

Xenobiotica, 1999, Vol.29 (4), p.361-393

1999

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Disposition of sumatriptan in laboratory animals and humans

Drug metabolism and disposition, 1993-09, Vol.21 (5), p.761

1993

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A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

Xenobiotica, 1999-03, Vol.29 (3), p.269-279

OGG, M. S.

1999

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Disposition of salmeterol xinafoate in laboratory animals and humans

Drug metabolism and disposition, 1993-11, Vol.21 (6), p.1022

1993

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The disposition and metabolism of [14C]fluconazole in humans

Drug metabolism and disposition, 1991-07, Vol.19 (4), p.764

1991

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The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A

Drug metabolism and disposition, 1996-05, Vol.24 (5), p.555

1996

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Neural dysfunction during hypoglycaemia

Archives of disease in childhood, 1988-11, Vol.63 (11), p.1353-1358

1988

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Molecular Modelling of Lanosterol 14α-Demethylase (CYPSl) from Saccharomyces Cerevisiae via Homology with CYP102, a Unique Bacterial Cytochrome P450 Isoform: Quantitative Structure-Activity Relationships (QSARs) within two Related Series of Antifungal Azole Derivatives

Journal of enzyme inhibition, 1999, Vol.14 (3), p.175-192

1999

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A comparative study of 1-substituted imidazole and 1,2,4-triazole antifungal compounds as inhibitors of testosterone hydroxylations catalysed by mouse hepatic microsomal cytochromes P-450

Biochemical pharmacology, 1988-12, Vol.37 (24), p.4643-4651

1988

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Gas chromatographic method for the determination of fluconazole, a novel antifungal agent, in human plasma and urine

Journal of chromatography, 1986-11, Vol.383 (1), p.179-186

1986

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The effects of anesthesia and surgery on metabolic homeostasis in infancy and childhood

Journal of pediatric surgery, 1990-05, Vol.25 (5), p.472-478

1990

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Genetic analysis of the human cytochrome P450 CYP2C9 locus

Pharmacogenetics (London), 1996-10, Vol.6 (5), p.429-439

1996

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High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds

The emerging importance of predictive ADME simulation in drug discovery

Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans

Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6 substrate metabolism

Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity

Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans

Molecular modelling of CYP3A4 from an alignment with CYP102: Identification of key interactions between putative active site residues and CYP3A-specific chemicals

Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102

Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform

Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily

Correction of acidosis in hemodialysis patients increases the sensitivity of the parathyroid glands to calcium

Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver

Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4

Disposition of sumatriptan in laboratory animals and humans

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

Disposition of salmeterol xinafoate in laboratory animals and humans

The disposition and metabolism of [14C]fluconazole in humans

The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A

Neural dysfunction during hypoglycaemia

Molecular Modelling of Lanosterol 14α-Demethylase (CYPSl) from Saccharomyces Cerevisiae via Homology with CYP102, a Unique Bacterial Cytochrome P450 Isoform: Quantitative Structure-Activity Relationships (QSARs) within two Related Series of Antifungal Azole Derivatives

A comparative study of 1-substituted imidazole and 1,2,4-triazole antifungal compounds as inhibitors of testosterone hydroxylations catalysed by mouse hepatic microsomal cytochromes P-450

Gas chromatographic method for the determination of fluconazole, a novel antifungal agent, in human plasma and urine

The effects of anesthesia and surgery on metabolic homeostasis in infancy and childhood

Genetic analysis of the human cytochrome P450 CYP2C9 locus

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