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Trisubstituted Acridines as G-quadruplex Telomere Targeting Agents. Effects of Extensions of the 3,6- and 9-Side Chains on Quadruplex Binding, Telomerase Activity, and Cell Proliferation

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.582-599

2006

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Structure-Based Design of Selective and Potent G Quadruplex-Mediated Telomerase Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2001-04, Vol.98 (9), p.4844-4849

2001

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Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2- a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2- a]pyridines

Bioorganic & medicinal chemistry, 2008-01, Vol.16 (2), p.683-691

2008

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Loop and Backbone Modifications of Peptide Nucleic Acid Improve G-Quadruplex Binding Selectivity

Journal of the American Chemical Society, 2009-12, Vol.131 (51), p.18415-18424

2009

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Novel Dicationic Imidazo[1,2-a]pyridines and 5,6,7,8-Tetrahydro-imidazo[1,2-a]pyridines as Antiprotozoal Agents

Journal of medicinal chemistry, 2004-07, Vol.47 (14), p.3658-3664

2004

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Strand Invasion of DNA Quadruplexes by PNA: Comparison of Homologous and Complementary Hybridization

Chembiochem : a European journal of chemical biology, 2013-08, Vol.14 (12), p.1476-1484

2013

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Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors

Journal of medicinal chemistry, 2003-10, Vol.46 (21), p.4463-4476

2003

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High-Affinity Homologous Peptide Nucleic Acid Probes for Targeting a Quadruplex-Forming Sequence from a MYC Promoter Element

Biochemistry (Easton), 2007-09, Vol.46 (37), p.10433-10443

2007

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Diphenyl Furans and Aza Analogs: Effects of Structural Modification on In Vitro Activity, DNA Binding, and Accumulation and Distribution in Trypanosomes

Antimicrobial Agents and Chemotherapy, 2007-08, Vol.51 (8), p.2801-2810

2007

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Biosensor-surface plasmon resonance: Quantitative analysis of small molecule–nucleic acid interactions

Methods (San Diego, Calif.), 2007-06, Vol.42 (2), p.150-161

2007

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Antiparasitic compounds that target DNA

Biochimie, 2008-07, Vol.90 (7), p.999-1014

2008

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A High-Throughput, High-Resolution Strategy for the Study of Site-Selective DNA Binding Agents: Analysis of a “Highly Twisted” Benzimidazole-Diamidine

Journal of the American Chemical Society, 2006-06, Vol.128 (24), p.7846-7854

2006

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Effects of Compound Structure on Carbazole Dication−DNA Complexes: Tests of the Minor-Groove Complex Models

Biochemistry (Easton), 2000-10, Vol.39 (39), p.12091-12101

2000

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Biosensor‐Surface Plasmon Resonance Methods for Quantitative Analysis of Biomolecular Interactions

Methods in Cell Biology, 2008, Vol.84, p.53-77

2008

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Synthesis and DNA Interactions of Benzimidazole Dications Which Have Activity against Opportunistic Infections

Journal of medicinal chemistry, 1996-03, Vol.39 (7), p.1452-1462

1996

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Nucleic Acid Interactions of Unfused Aromatic Cations: Evaluation of Proposed Minor-Groove, Major-Groove, and Intercalation Binding Modes

Journal of the American Chemical Society, 1998-10, Vol.120 (40), p.10310-10321

1998

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Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes

Chemical communications (Cambridge, England), 2011-08, Vol.47 (30), p.8524-8526

2011

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Synthesis and Antiprotozoal Activity of Aza-Analogues of Furamidine

Journal of medicinal chemistry, 2003-10, Vol.46 (22), p.4761-4769

2003

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DNA triple-helix specific intercalators as antigene enhancers: Unfused aromatic cations

Biochemistry (Easton), 1993-10, Vol.32 (40), p.10614-10621

1993

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DNA Sequence Dependent Monomer−Dimer Binding Modulation of Asymmetric Benzimidazole Derivatives

Journal of the American Chemical Society, 2004-01, Vol.126 (1), p.143-153

2004

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Synthesis, DNA Affinity, and Antiprotozoal Activity of Fused Ring Dicationic Compounds and Their Prodrugs

Journal of medicinal chemistry, 2005-08, Vol.48 (17), p.5480-5488

2005

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Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes

European journal of medicinal chemistry, 2007-04, Vol.42 (4), p.552-557

2007

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Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

Bioorganic & medicinal chemistry, 2004-10, Vol.12 (20), p.5405-5413

2004

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Molecular Determinants for DNA Minor Groove Recognition: Design of a Bis-Guanidinium Derivative of Ethidium That Is Highly Selective for AT-Rich DNA Sequences

Biochemistry (Easton), 2005-02, Vol.44 (6), p.1941-1952

2005

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Unusually Strong Binding to the DNA Minor Groove by a Highly Twisted Benzimidazole Diphenylether: Induced Fit and Bound Water

Biochemistry (Easton), 2007-06, Vol.46 (23), p.6944-6956

2007

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Trisubstituted Acridines as G-quadruplex Telomere Targeting Agents. Effects of Extensions of the 3,6- and 9-Side Chains on Quadruplex Binding, Telomerase Activity, and Cell Proliferation

Structure-Based Design of Selective and Potent G Quadruplex-Mediated Telomerase Inhibitors

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2- a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2- a]pyridines

Loop and Backbone Modifications of Peptide Nucleic Acid Improve G-Quadruplex Binding Selectivity

Novel Dicationic Imidazo[1,2-a]pyridines and 5,6,7,8-Tetrahydro-imidazo[1,2-a]pyridines as Antiprotozoal Agents

Strand Invasion of DNA Quadruplexes by PNA: Comparison of Homologous and Complementary Hybridization

Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors

High-Affinity Homologous Peptide Nucleic Acid Probes for Targeting a Quadruplex-Forming Sequence from a MYC Promoter Element

Diphenyl Furans and Aza Analogs: Effects of Structural Modification on In Vitro Activity, DNA Binding, and Accumulation and Distribution in Trypanosomes

Biosensor-surface plasmon resonance: Quantitative analysis of small molecule–nucleic acid interactions

Antiparasitic compounds that target DNA

A High-Throughput, High-Resolution Strategy for the Study of Site-Selective DNA Binding Agents: Analysis of a “Highly Twisted” Benzimidazole-Diamidine

Effects of Compound Structure on Carbazole Dication−DNA Complexes: Tests of the Minor-Groove Complex Models

Biosensor‐Surface Plasmon Resonance Methods for Quantitative Analysis of Biomolecular Interactions

Synthesis and DNA Interactions of Benzimidazole Dications Which Have Activity against Opportunistic Infections

Nucleic Acid Interactions of Unfused Aromatic Cations: Evaluation of Proposed Minor-Groove, Major-Groove, and Intercalation Binding Modes

Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes

Synthesis and Antiprotozoal Activity of Aza-Analogues of Furamidine

DNA triple-helix specific intercalators as antigene enhancers: Unfused aromatic cations

DNA Sequence Dependent Monomer−Dimer Binding Modulation of Asymmetric Benzimidazole Derivatives

Synthesis, DNA Affinity, and Antiprotozoal Activity of Fused Ring Dicationic Compounds and Their Prodrugs

Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes

Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

Molecular Determinants for DNA Minor Groove Recognition: Design of a Bis-Guanidinium Derivative of Ethidium That Is Highly Selective for AT-Rich DNA Sequences

Unusually Strong Binding to the DNA Minor Groove by a Highly Twisted Benzimidazole Diphenylether: Induced Fit and Bound Water

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