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A review: Biologically active 3,4-heterocycle-fused coumarins

European journal of medicinal chemistry, 2021-02, Vol.212, p.113034, Article 113034

2021

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Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors

Future medicinal chemistry, 2019-05, Vol.11 (10), p.1119-1136

2019

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Downregulation of aromatase by siRNA decreases acetylcholinesterase mRNA and specific activity in SH-SY5Y cells

Journal of Research in Pharmacy, 2022-01, Vol.26 (2), p.362

Tuba TÜYLÜ KÜÇÜKKILINÇ

2022

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Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease

MedChemComm, 2019-06, Vol.1 (6), p.118-126

2019

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Design, synthesis, and biological evaluation of novel indanone-based hybrids as multifunctional cholinesterase inhibitors for Alzheimer's disease

Journal of molecular structure, 2021-04, Vol.1229, p.129787, Article 129787

2021

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Novel indanone-chalcone esters with potential anti-Alzheimer effects designed using hybridization and bioisosteric replacement approaches

Medicinal chemistry research, 2023-08, Vol.32 (8), p.1701-1712

2023

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Hybridization‐based design of novel anticholinesterase indanone–carbamates for Alzheimer's disease: Synthesis, biological evaluation, and docking studies

Archiv der Pharmazie (Weinheim), 2021-07, Vol.354 (7), p.e2000453-n/a

2021

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3‐Aryl Coumarin Derivatives Bearing Aminoalkoxy Moiety as Multi‐Target‐Directed Ligands against Alzheimer's Disease

Chemistry & biodiversity, 2019-05, Vol.16 (5), p.e1800436-n/a

2019

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New classes of carbazoles as potential multi-functional anti-Alzheimer’s agents

Bioorganic chemistry, 2019-10, Vol.91, p.103164-103164, Article 103164

2019

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Chromone–lipoic acid conjugate: Neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities

Daru, 2021-01, Vol.29 (1), p.23-38

2021

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Novel 2-Arylbenzimidazole derivatives as multi-targeting agents to treat Alzheimer’s disease

Medicinal chemistry research, 2017-07, Vol.26 (7), p.1506-1515

2017

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Novel Coumarin–Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer’s Disease

Frontiers in chemistry, 2022-06, Vol.10, p.895483-895483

2022

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Phenelzine protects against acetaminophen induced apoptosis in HepG2 cells

Drug and chemical toxicology (New York, N.Y. 1978), 2024, Vol.ahead-of-print (ahead-of-print), p.1-9

2024

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Combined effect of fulvestrant and low dose BPA: comparative implications on EMT, apoptosis, and TGF-β1 signaling in HepG2 cells

Drug and chemical toxicology (New York, N.Y. 1978), 2022-09, Vol.45 (5), p.2285-2291

2022

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Novel 1,2,4-triazole derivatives containing the naphthalene moiety as selective butyrylcholinesterase inhibitors: Design, synthesis, and biological evaluation

Archiv der Pharmazie (Weinheim), 2024-07, p.e2400406

2024

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Low‐dose bisphenol A induces RIPK1‐mediated necroptosis in SH‐SY5Y cells: Effects on TNF‐α and acetylcholinesterase

Journal of biochemical and molecular toxicology, 2019-01, Vol.33 (1), p.e22233-n/a

2019

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Downregulation of aromatase by siRNA decreases acetylcholinesterase mRNA and specific activity in SHSY5Y cells

Journal of Research in Pharmacy, 2022, Vol.26 (2) (26 (2)), p.362-369

TÜYLÜ KÜÇÜKKILINÇ, Tuba

2022

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Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds

European journal of medicinal chemistry, 2018-05, Vol.152, p.600-614

2018

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Novel multi-targeted agents for Alzheimer's disease: Synthesis, biological evaluation, and molecular modeling of novel 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazoles

Bioorganic chemistry, 2017-06, Vol.72, p.208-214

2017

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Folat Metabolizmasının Nörodejeneratif Hastalıklardaki Rolü

FABAD journal of pharmaceutical sciences, 2020-12, Vol.45 (3), p.243-252

2020

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Meme Kanseri Tedavisindeki Güncel Yaklaşımlar

Hacettepe University Journal of the Faculty of Pharmacy, 2022-01

2022

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In Vitro and In Silico Determination of Some N-ferrocenylmethylaniline Derivatives as Anti-Proliferative Agents Against MCF-7 Human Breast Cancer Cell Lines

Anti-cancer agents in medicinal chemistry, 2022-01, Vol.22 (7), p.1426-1437

2022

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Synthesis and biological evaluation of new N-benzylpyridinium-based benzoheterocycles as potential anti-Alzheimer’s agents

Bioorganic chemistry, 2019-03, Vol.83, p.559-568

2019

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Novel 3-phenylcoumarin–lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease

Bioorganic chemistry, 2018-09, Vol.79, p.223-234

2018

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Neurotoxic effects of bisphenol A on SH-SY5Y neuroblastoma cells via nitric oxide

Journal of Research in Pharmacy, 2019-01, Vol.23 (3), p.354-359

2019

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A review: Biologically active 3,4-heterocycle-fused coumarins

Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors

Downregulation of aromatase by siRNA decreases acetylcholinesterase mRNA and specific activity in SH-SY5Y cells

Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease

Design, synthesis, and biological evaluation of novel indanone-based hybrids as multifunctional cholinesterase inhibitors for Alzheimer's disease

Novel indanone-chalcone esters with potential anti-Alzheimer effects designed using hybridization and bioisosteric replacement approaches

Hybridization‐based design of novel anticholinesterase indanone–carbamates for Alzheimer's disease: Synthesis, biological evaluation, and docking studies

3‐Aryl Coumarin Derivatives Bearing Aminoalkoxy Moiety as Multi‐Target‐Directed Ligands against Alzheimer's Disease

New classes of carbazoles as potential multi-functional anti-Alzheimer’s agents

Chromone–lipoic acid conjugate: Neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities

Novel 2-Arylbenzimidazole derivatives as multi-targeting agents to treat Alzheimer’s disease

Novel Coumarin–Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer’s Disease

Phenelzine protects against acetaminophen induced apoptosis in HepG2 cells

Combined effect of fulvestrant and low dose BPA: comparative implications on EMT, apoptosis, and TGF-β1 signaling in HepG2 cells

Novel 1,2,4-triazole derivatives containing the naphthalene moiety as selective butyrylcholinesterase inhibitors: Design, synthesis, and biological evaluation

Low‐dose bisphenol A induces RIPK1‐mediated necroptosis in SH‐SY5Y cells: Effects on TNF‐α and acetylcholinesterase

Downregulation of aromatase by siRNA decreases acetylcholinesterase mRNA and specific activity in SHSY5Y cells

Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds

Novel multi-targeted agents for Alzheimer's disease: Synthesis, biological evaluation, and molecular modeling of novel 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazoles

Folat Metabolizmasının Nörodejeneratif Hastalıklardaki Rolü

Meme Kanseri Tedavisindeki Güncel Yaklaşımlar

In Vitro and In Silico Determination of Some N-ferrocenylmethylaniline Derivatives as Anti-Proliferative Agents Against MCF-7 Human Breast Cancer Cell Lines

Synthesis and biological evaluation of new N-benzylpyridinium-based benzoheterocycles as potential anti-Alzheimer’s agents

Novel 3-phenylcoumarin–lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease

Neurotoxic effects of bisphenol A on SH-SY5Y neuroblastoma cells via nitric oxide

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