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The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life

Angewandte Chemie International Edition, 2017-09, Vol.56 (37), p.11037-11043

Szostak, Jack W.

International ed. in English, 2017

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Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells

Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6162), p.1098-1100

2013

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Competition between model protocells driven by an encapsulated catalyst

Nature chemistry, 2013-06, Vol.5 (6), p.495-501

2013

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Progress Toward Synthetic Cells

Annual review of biochemistry, 2014-01, Vol.83 (1), p.615-640

2014

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A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension

Journal of the American Chemical Society, 2016-09, Vol.138 (36), p.11996-12002

2016

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Physical effects underlying the transition from primitive to modern cell membranes

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (13), p.5249-5254

2011

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Coupled Growth and Division of Model Protocell Membranes

Journal of the American Chemical Society, 2009-04, Vol.131 (15), p.5705-5713

2009

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A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5′-phosphoro-2-aminoimidazolide

Biochemistry (Easton), 2017-10, Vol.56 (43), p.5739-5747

2017

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A simple physical mechanism enables homeostasis in primitive cells

Nature chemistry, 2016-05, Vol.8 (5), p.448-453

2016

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Constraints on the emergence of RNA through non-templated primer extension with mixtures of potentially prebiotic nucleotides

Nucleic acids research, 2024-05

2024

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Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying

Proceedings of the National Academy of Sciences - PNAS, 2022-04, Vol.119 (17), p.e2116429119-e2116429119

2022

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Template‐Directed Copying of RNA by Non‐enzymatic Ligation

Angewandte Chemie International Edition, 2020-09, Vol.59 (36), p.15682-15687

International ed. in English, 2020

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Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

Nature medicine, 2006-10, Vol.12 (10), p.1133-1138

2006

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Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation

Journal of the American Chemical Society, 2017-07, Vol.139 (26), p.8780-8783

2017

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Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension

Biochemistry (Easton), 2019-02, Vol.58 (6), p.755-762

2019

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Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions

Biophysical journal, 2014-10, Vol.107 (7), p.1582-1590

2014

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The eightfold path to non-enzymatic RNA replication

Journal of systems chemistry, 2012-02, Vol.3 (1), p.2-14, Article 2

Szostak, Jack W

2012

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Collaboration between primitive cell membranes and soluble catalysts

Nature communications, 2016-03, Vol.7 (1), p.11041-11041, Article 11041

2016

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The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis

Journal of the American Chemical Society, 2021-03, Vol.143 (9), p.3267-3279

2021

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Expanding roles for diverse physical phenomena during the origin of life

Annual review of biophysics, 2010-01, Vol.39 (1), p.245-263

2010

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Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

Nature communications, 2017-05, Vol.8 (1), p.15270-15270, Article 15270

2017

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Copying of Mixed-Sequence RNA Templates inside Model Protocells

Journal of the American Chemical Society, 2018-04, Vol.140 (15), p.5171-5178

2018

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Deep sequencing of non-enzymatic RNA primer extension

Nucleic acids research, 2020-07, Vol.48 (12), p.e70-e70

2020

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Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity

Nature chemistry, 2013-05, Vol.5 (5), p.390-394

2013

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Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides

eLife, 2016-06, Vol.5

2016

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The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life

Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells

Competition between model protocells driven by an encapsulated catalyst

Progress Toward Synthetic Cells

A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension

Physical effects underlying the transition from primitive to modern cell membranes

Coupled Growth and Division of Model Protocell Membranes

A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5′-phosphoro-2-aminoimidazolide

A simple physical mechanism enables homeostasis in primitive cells

Constraints on the emergence of RNA through non-templated primer extension with mixtures of potentially prebiotic nucleotides

Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying

Template‐Directed Copying of RNA by Non‐enzymatic Ligation

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation

Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension

Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions

The eightfold path to non-enzymatic RNA replication

Collaboration between primitive cell membranes and soluble catalysts

The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis

Expanding roles for diverse physical phenomena during the origin of life

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

Copying of Mixed-Sequence RNA Templates inside Model Protocells

Deep sequencing of non-enzymatic RNA primer extension

Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity

Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides

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