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Structural Basis for the Inhibition of the LSD1 Histone Demethylase by the Antidepressant trans-2-Phenylcyclopropylamine

Biochemistry (Easton), 2007-07, Vol.46 (27), p.8058-8065

2007

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Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

Nature structural & molecular biology, 2007-06, Vol.14 (6), p.535-539

2007

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High-Throughput Assessment of Structural Continuity in Biologics

Analytical chemistry (Washington), 2018-02, Vol.90 (4), p.2970-2975

2018

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Discovery of Potent and Orally Bioavailable Pyridine N‑Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions

Journal of medicinal chemistry, 2022-08, Vol.65 (15), p.10419-10440

2022

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Development of a high-content imaging assay for screening compound aggregation

Analytical biochemistry, 2018-10, Vol.559, p.30-33

2018

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Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents

The Journal of biological chemistry, 2004-05, Vol.279 (21), p.22727

2004

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A Mechanism-Based Inactivator for Histone Demethylase LSD1

Journal of the American Chemical Society, 2006-04, Vol.128 (14), p.4536-4537

2006

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Mechanistic Analysis of a Suicide Inactivator of Histone Demethylase LSD1

Biochemistry (Easton), 2007-06, Vol.46 (23), p.6892-6902

2007

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Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.217-222

2016

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Development of Nonsteroidal Anti-Inflammatory Drug Analogs and Steroid Carboxylates Selective for Human Aldo-Keto Reductase Isoforms: Potential Antineoplastic Agents That Work Independently of Cyclooxygenase Isozymes

Molecular pharmacology, 2005-01, Vol.67 (1), p.60-68

2005

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Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery

Scientific reports, 2019-09, Vol.9 (1), p.13078-11, Article 13078

2019

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Formation of 8-Oxo-7,8-dihydro-2‘-deoxyguanosine (8-Oxo-dGuo) by PAH o-Quinones: Involvement of Reactive Oxygen Species and Copper(II)/Copper(I) Redox Cycling

Chemical research in toxicology, 2005-06, Vol.18 (6), p.1026-1037

2005

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Protein Phosphorylation by Semisynthesis: From Paper to Practice

Methods in enzymology, 2009, Vol.462, p.1-24

2009

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Development of a high-throughput screen to detect inhibitors of TRPS1 sumoylation

Assay and drug development technologies, 2013-06, Vol.11 (5), p.308

2013

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Mechanism-Based Inactivation of COX-1 by Red Wine m-Hydroquinones: A Structure−Activity Relationship Study

Journal of natural products (Washington, D.C.), 2004-11, Vol.67 (11), p.1777-1782

2004

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Analysis of Serotonin N-Acetyltransferase Regulation in Vitro and in Live Cells Using Protein Semisynthesis

Biochemistry (Easton), 2008-09, Vol.47 (39), p.10407-10419

2008

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De Novo Discovery of Serotonin N-Acetyltransferase Inhibitors

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5330-5338

2007

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Viniferin Formation by COX-1: Evidence for Radical Intermediates during Co-oxidation of Resveratrol

Journal of natural products (Washington, D.C.), 2005-01, Vol.68 (1), p.36-42

2005

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Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

Journal of bone and mineral research, 1997-09, Vol.12 (9), p.1396-1406

1997

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Gut-Restricted Selective Cyclooxygenase‑2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11570-11596

2021

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Co‐Oxidation by Cyclooxygenases

Current Protocols in Toxicology, 2009-11, Vol.42 (1)

2009

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Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL‑1

ACS medicinal chemistry letters, 2023-07, Vol.14 (7), p.955-961

2023

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Synthesis of P1-citronellyl-P2-α-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG

Bioorganic & medicinal chemistry letters, 2001-12, Vol.11 (24), p.3107-3110

2001

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Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2133-2133

2022

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Resveratrol is a Peroxidase-mediated Inactivator of COX-1 but Not COX-2

The Journal of biological chemistry, 2004-05, Vol.279 (21), p.22727-22737

2004

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Structural Basis for the Inhibition of the LSD1 Histone Demethylase by the Antidepressant trans-2-Phenylcyclopropylamine

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

High-Throughput Assessment of Structural Continuity in Biologics

Discovery of Potent and Orally Bioavailable Pyridine N‑Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions

Development of a high-content imaging assay for screening compound aggregation

Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents

A Mechanism-Based Inactivator for Histone Demethylase LSD1

Mechanistic Analysis of a Suicide Inactivator of Histone Demethylase LSD1

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

Development of Nonsteroidal Anti-Inflammatory Drug Analogs and Steroid Carboxylates Selective for Human Aldo-Keto Reductase Isoforms: Potential Antineoplastic Agents That Work Independently of Cyclooxygenase Isozymes

Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery

Formation of 8-Oxo-7,8-dihydro-2‘-deoxyguanosine (8-Oxo-dGuo) by PAH o-Quinones: Involvement of Reactive Oxygen Species and Copper(II)/Copper(I) Redox Cycling

Protein Phosphorylation by Semisynthesis: From Paper to Practice

Development of a high-throughput screen to detect inhibitors of TRPS1 sumoylation

Mechanism-Based Inactivation of COX-1 by Red Wine m-Hydroquinones: A Structure−Activity Relationship Study

Analysis of Serotonin N-Acetyltransferase Regulation in Vitro and in Live Cells Using Protein Semisynthesis

De Novo Discovery of Serotonin N-Acetyltransferase Inhibitors

Viniferin Formation by COX-1: Evidence for Radical Intermediates during Co-oxidation of Resveratrol

Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

Gut-Restricted Selective Cyclooxygenase‑2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer

Co‐Oxidation by Cyclooxygenases

Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL‑1

Synthesis of P1-citronellyl-P2-α-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG

Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355

Resveratrol is a Peroxidase-mediated Inactivator of COX-1 but Not COX-2

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