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First‐in‐class cardiolipin‐protective compound as a therapeutic agent to restore mitochondrial bioenergetics

British journal of pharmacology, 2014-04, Vol.171 (8), p.2029-2050

Szeto, Hazel H

2014

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Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD

Journal of the American Society of Nephrology, 2017-10, Vol.28 (10), p.2856-2865

Szeto, Hazel H

2017

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Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury

Antioxidants & redox signaling, 2008-03, Vol.10 (3), p.601

Szeto, Hazel H

2008

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Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

Kidney international, 2016-11, Vol.90 (5), p.997-1011

2016

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Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle

American journal of physiology. Regulatory, integrative and comparative physiology, 2020-02, Vol.318 (2), p.R227-R233

2020

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Development of Mitochondria-targeted Aromatic-cationic Peptides for Neurodegenerative Diseases

Annals of the New York Academy of Sciences, 2008-12, Vol.1147 (1), p.112-121

Szeto, Hazel H.

2008

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The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action

The Journal of biological chemistry, 2020-05, Vol.295 (21), p.7452-7469

2020

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Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis

American journal of physiology. Renal physiology, 2014-05, Vol.306 (9), p.F970-F980

2014

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ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

The Journal of clinical investigation, 2019-08, Vol.129 (8), p.3387-3400

2019

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Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury

Journal of the American Society of Nephrology, 2011-06, Vol.22 (6), p.1041-1052

2011

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Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation

Free radical biology & medicine, 2018-02, Vol.115, p.179-190

2018

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Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy

Journal of applied physiology (1985), 2011-11, Vol.111 (5), p.1459-1466

2011

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

The Journal of clinical investigation, 2009-03, Vol.119 (3), p.573-581

2009

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The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age

Kidney international, 2017-05, Vol.91 (5), p.1126-1145

2017

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Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia

Biochimica et biophysica acta. Bioenergetics, 2015-10, Vol.1847 (10), p.1075-1084

2015

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Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness

Critical care medicine, 2011-07, Vol.39 (7), p.1749-1759

2011

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Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin‐induced cardiac and skeletal muscle myopathy

The Journal of physiology, 2015-04, Vol.593 (8), p.2017-2036

2015

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Partial Support Ventilation and Mitochondrial-Targeted Antioxidants Protect against Ventilator-Induced Decreases in Diaphragm Muscle Protein Synthesis

PloS one, 2015-09, Vol.10 (9), p.e0137693

2015

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Improving mitochondrial bioenergetics under ischemic conditions increases warm ischemia tolerance in the kidney

American journal of physiology. Renal physiology, 2015-01, Vol.308 (1), p.F11-F21

2015

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Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury

The Journal of biological chemistry, 2004-08, Vol.279 (33), p.34682-34690

2004

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Targeting Mitochondria by SS-31 Ameliorates the Whole Body Energy Status in Cancer- and Chemotherapy-Induced Cachexia

Cancers, 2021-02, Vol.13 (4), p.850

2021

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Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

Antioxidants & redox signaling, 2009-09, Vol.11 (9), p.2095

2009

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Characterization of Acute and Chronic Neuropathies Induced by Oxaliplatin in Mice and Differential Effects of a Novel Mitochondria-targeted Antioxidant on the Neuropathies

Anesthesiology (Philadelphia), 2014-02, Vol.120 (2), p.459-473

2014

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Cardiolipin-targeted peptides rejuvenate mitochondrial function, remodel mitochondria, and promote tissue regeneration during aging

Archives of biochemistry and biophysics, 2018-12, Vol.660, p.137-148

2018

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A Role for Heterodimerization of μ and δ Opiate Receptors in Enhancing Morphine Analgesia

Proceedings of the National Academy of Sciences - PNAS, 2004-04, Vol.101 (14), p.5135-5139

2004

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First‐in‐class cardiolipin‐protective compound as a therapeutic agent to restore mitochondrial bioenergetics

Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD

Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle

Development of Mitochondria-targeted Aromatic-cationic Peptides for Neurodegenerative Diseases

The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action

Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury

Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation

Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age

Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia

Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness

Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin‐induced cardiac and skeletal muscle myopathy

Partial Support Ventilation and Mitochondrial-Targeted Antioxidants Protect against Ventilator-Induced Decreases in Diaphragm Muscle Protein Synthesis

Improving mitochondrial bioenergetics under ischemic conditions increases warm ischemia tolerance in the kidney

Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury

Targeting Mitochondria by SS-31 Ameliorates the Whole Body Energy Status in Cancer- and Chemotherapy-Induced Cachexia

Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

Characterization of Acute and Chronic Neuropathies Induced by Oxaliplatin in Mice and Differential Effects of a Novel Mitochondria-targeted Antioxidant on the Neuropathies

Cardiolipin-targeted peptides rejuvenate mitochondrial function, remodel mitochondria, and promote tissue regeneration during aging

A Role for Heterodimerization of μ and δ Opiate Receptors in Enhancing Morphine Analgesia

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