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Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Journal of the American Chemical Society, 2003-04, Vol.125 (14), p.4087-4096

2003

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Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4298-4302

2008

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Synthesis of Purines and Other Fused Imidazoles from Acyclic Amidines and Guanidines

Organic letters, 2005-04, Vol.7 (9), p.1833-1835

2005

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Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4455-4458

2006

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Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5

Journal of organic chemistry, 2012-09, Vol.77 (17), p.7319-7329

2012

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Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3947-3950

2003

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Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ETB Selectivity

Journal of medicinal chemistry, 1999-09, Vol.42 (18), p.3668-3678

1999

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Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (24), p.6226-6230

2006

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The Synthesis of Bromomethyltrifluoroborates through Continuous Flow Chemistry

Organic process research & development, 2014-11, Vol.18 (11), p.1354-1359

2014

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Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity

Journal of medicinal chemistry, 2006-06, Vol.49 (12), p.3563-3580

2006

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One-Step, Nonenzymatic Synthesis of O-Acetyl-ADP-ribose and Analogues from NAD and Carboxylates

Journal of organic chemistry, 2011-08, Vol.76 (16), p.6465-6474

2011

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Aromatic heterocycle-based DPP-IV inhibitors: xanthines and related structural types

Current topics in medicinal chemistry, 2007-03, Vol.7 (6), p.569-578

2007

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Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesity

Current pharmaceutical design, 2004-01, Vol.10 (28), p.3481-3504

2004

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Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Journal of medicinal chemistry, 2003-07, Vol.46 (16), p.3437-3440

2003

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Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5543-5546

2004

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2,4-Diaminopyrimidine Derivatives as Potent Growth Hormone Secretagogue Receptor Antagonists

Journal of medicinal chemistry, 2006-04, Vol.49 (8), p.2568-2578

2006

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Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4459-4469

2006

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Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

Journal of medicinal chemistry, 2003-05, Vol.46 (11), p.2093-2103

2003

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Potent, selective inhibitors of protein tyrosine phosphatase 1B

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1887-1890

2003

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New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models

Journal of medicinal chemistry, 2001-12, Vol.44 (25), p.4416-4430

2001

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Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5723-5730

2006

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Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: Side chain exploration

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1864-1868

2006

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Structure–activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (7), p.1825-1828

2005

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Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 3. Discovery of a Potent, 2-Nonaryl, Highly Selective ETA Antagonist (A-216546)

Journal of medicinal chemistry, 1998-08, Vol.41 (17), p.3261-3275

1998

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Total Synthesis of Diplamine, a Cytotoxic Pyridoacridine Alkaloid from a Pacific Tunicate

Journal of organic chemistry, 1994-07, Vol.59 (13), p.3512-3513

1994

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Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors

Synthesis of Purines and Other Fused Imidazoles from Acyclic Amidines and Guanidines

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5

Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ETB Selectivity

Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors

The Synthesis of Bromomethyltrifluoroborates through Continuous Flow Chemistry

Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity

One-Step, Nonenzymatic Synthesis of O-Acetyl-ADP-ribose and Analogues from NAD and Carboxylates

Aromatic heterocycle-based DPP-IV inhibitors: xanthines and related structural types

Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesity

Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

2,4-Diaminopyrimidine Derivatives as Potent Growth Hormone Secretagogue Receptor Antagonists

Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists

Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

Potent, selective inhibitors of protein tyrosine phosphatase 1B

New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond

Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: Side chain exploration

Structure–activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 3. Discovery of a Potent, 2-Nonaryl, Highly Selective ETA Antagonist (A-216546)

Total Synthesis of Diplamine, a Cytotoxic Pyridoacridine Alkaloid from a Pacific Tunicate

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