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Various plasmid strategies limit the effect of bacterial restriction–modification systems against conjugation

Nucleic acids research, 2024-10

2024

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Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems

Current biology, 2020-10, Vol.30 (19), p.R1189-R1202

2020

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Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (27), p.9798-9803

2014

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Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition

Cell host & microbe, 2022-01, Vol.30 (1), p.31-40.e5

2022

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5' modifications to CRISPR-Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

Nucleic acids research, 2020-07, Vol.48 (12), p.6811-6823

2020

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Mitochondrial import, health and mtDNA copy number variability seen when using type II and type V CRISPR effectors

Journal of cell science, 2020-09, Vol.133 (18)

2020

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Multi-layered genome defences in bacteria

Current opinion in microbiology, 2024-04, Vol.78, p.102436-102436, Article 102436

2024

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CRISPR-Cas12a-mediated DNA clamping triggers target-strand cleavage

Nature chemical biology, 2022-09, Vol.18 (9), p.1014-1022

2022

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ENDO-Pore: high-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing

Nucleic acids research, 2021-11, Vol.49 (20), p.e118-e118

2021

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Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity

Nucleic acids research, 2016-09, Vol.44 (16), p.7817-7829

2016

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Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells

Essays in biochemistry, 2019-07, Vol.63 (2), p.237-266

2019

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Short-range translocation by a restriction enzyme motor triggers diffusion along DNA

Nature chemical biology, 2024-06, Vol.20 (6), p.689-698

2024

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Characterization of the Type III restriction endonuclease PstII from Providencia stuartii

Nucleic acids research, 2019-12, Vol.47 (21), p.11477-11479

2019

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The Helicase-Like Domains of Type III Restriction Enzymes Trigger Long-Range Diffusion Along DNA

Science (American Association for the Advancement of Science), 2013-04, Vol.340 (6130), p.353-356

2013

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The bacterial defense system MADS interacts with CRISPR-Cas to limit phage infection and escape

Cell host & microbe, 2024-08, Vol.32 (8), p.1412-1426.e11

2024

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CgII cleaves DNA using a mechanism distinct from other ATP-dependent restriction endonucleases

Nucleic acids research, 2017-08, Vol.45 (14), p.8435-8447

2017

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The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a

Genes, 2019-02, Vol.10 (2), p.169

2019

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Translocation, switching and gating: potential roles for ATP in long-range communication on DNA by Type III restriction endonucleases

Biochemical Society transactions, 2011-04, Vol.39 (2), p.589-594

Szczelkun, Mark D

2011

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Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes

Nucleic acids research, 2016-05, Vol.44 (9), p.4396-4408

2016

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Re-evaluating the kinetics of ATP hydrolysis during initiation of DNA sliding by Type III restriction enzymes

Nucleic acids research, 2015-12, Vol.43 (22), p.10870-10881

2015

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From observing to predicting single-cell structure and function with high-throughput/high-content microscopy

Essays in biochemistry, 2019-07, Vol.63 (2), p.197-208

2019

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Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity

Nucleic acids research, 2019-01, Vol.47 (2), p.868-882

2019

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Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations

Nucleic acids research, 2015-12, Vol.43 (21), p.10430

2015

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Sequence-specific assembly of FtsK hexamers establishes directional translocation on DNA

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (47), p.20263-20268

2010

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The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor

Nucleic acids research, 2018-03, Vol.46 (5), p.2560-2572

2018

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Various plasmid strategies limit the effect of bacterial restriction–modification systems against conjugation

Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems

Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes

Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition

5' modifications to CRISPR-Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

Mitochondrial import, health and mtDNA copy number variability seen when using type II and type V CRISPR effectors

Multi-layered genome defences in bacteria

CRISPR-Cas12a-mediated DNA clamping triggers target-strand cleavage

ENDO-Pore: high-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing

Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity

Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells

Short-range translocation by a restriction enzyme motor triggers diffusion along DNA

Characterization of the Type III restriction endonuclease PstII from Providencia stuartii

The Helicase-Like Domains of Type III Restriction Enzymes Trigger Long-Range Diffusion Along DNA

The bacterial defense system MADS interacts with CRISPR-Cas to limit phage infection and escape

CgII cleaves DNA using a mechanism distinct from other ATP-dependent restriction endonucleases

The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a

Translocation, switching and gating: potential roles for ATP in long-range communication on DNA by Type III restriction endonucleases

Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes

Re-evaluating the kinetics of ATP hydrolysis during initiation of DNA sliding by Type III restriction enzymes

From observing to predicting single-cell structure and function with high-throughput/high-content microscopy

Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity

Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations

Sequence-specific assembly of FtsK hexamers establishes directional translocation on DNA

The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor

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