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Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues

Scientific reports, 2020-12, Vol.10 (1), p.22155-22155, Article 22155

2020

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Native high-resolution mass spectrometry analysis of noncovalent protein complexes up to 450 kDa

Bioanalysis, 2020-10, Vol.12 (19), p.1353-1362

2020

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Systematic optimization of targeted and multiplexed MS-based screening workflows for protein biomarkers

Bioanalysis, 2022-03, Vol.14 (6), p.341-356

2022

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Microvilli Morphology Can Affect Efflux Active P-Glycoprotein in Confluent MDCKII -hMDR1-NKI and Caco-2 Cell Monolayers

Drug metabolism and disposition, 2017-02, Vol.45 (2), p.145-151

2017

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Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency

PloS one, 2011-08, Vol.6 (8), p.e23570

2011

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Application of high-resolution MS for development of peptide and large-molecule drug candidates

Bioanalysis, 2016-02, Vol.8 (3), p.169-177

2016

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Development of a highly sensitive and selective UPLC/MS/MS method for the simultaneous determination of testosterone and 5α-dihydrotestosterone in human serum to support testosterone replacement therapy for hypogonadism

Steroids, 2008-07, Vol.73 (6), p.601-610

2008

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Microflow UPLC and high-resolution MS as a sensitive and robust platform for quantitation of intact peptide hormones

Bioanalysis, 2019-07, Vol.11 (13), p.1275-1289

2019

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Covalent Adduction of Human Serum Albumin by 4-Hydroxy-2-Nonenal: Kinetic Analysis of Competing Alkylation Reactions

Biochemistry (Easton), 2006-09, Vol.45 (35), p.10521-10528

2006

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Intact mAb LC–MS for drug concentration from pre-clinical studies: bioanalytical method performance and in-life samples

Bioanalysis, 2020-10, Vol.12 (19), p.1389-1403

2020

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A new era for proteomics

Bioanalysis, 2019-10, Vol.11 (19), p.1731-1735

2019

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Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression

Journal of neuroscience methods, 2004-12, Vol.140 (1), p.81-92

2004

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Identification of Proteins Adducted by Lipid Peroxidation Products in Plasma and Modifications of Apolipoprotein A1 with a Novel Biotinylated Phospholipid Probe

Journal of proteome research, 2008-10, Vol.7 (10), p.4237-4246

2008

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Integrating internal and external bioanalytical support to deliver a diversified pharmaceutical portfolio

Bioanalysis, 2014-05, Vol.6 (10), p.1311-1319

2014

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The Gyrolab™ immunoassay system: a platform for automated bioanalysis and rapid sample turnaround

Bioanalysis, 2013-07, Vol.5 (14), p.1765-1774

2013

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Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1

Neurobiology of disease, 2004-08, Vol.16 (3), p.572-580

2004

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Comparison of the quantification of a therapeutic protein using nominal and accurate mass MS/MS

Bioanalysis, 2012-03, Vol.4 (5), p.605-615

2012

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Absolute quantification of a therapeutic domain antibody using ultra-performance liquid chromatography-mass spectrometry and immunoassay

Bioanalysis, 2010-09, Vol.2 (9), p.1597-1608

2010

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Phospholipid−Protein Adducts of Lipid Peroxidation: Synthesis and Study of New Biotinylated Phosphatidylcholines

Chemical research in toxicology, 2007-02, Vol.20 (2), p.227-234

2007

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Quantitative immunocapture MS: current status and challenges in drug discovery

Bioanalysis, 2014-09, Vol.6 (18), p.2335-2337

2014

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Improved Sensitivity for Protein Turnover Quantification by Monitoring Immonium Ion Isotopologue Abundance

Analytical chemistry (Washington), 2019-08, Vol.91 (15), p.9732-9740

2019

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The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF

Neuropharmacology, 2006-03, Vol.50 (3), p.297-308

2006

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Ocular tissue distribution and pharmacokinetic study of a small 13kDa domain antibody after intravitreal, subconjuctival and eye drop administration in rabbits

Experimental eye research, 2018-02, Vol.167, p.14-17

2018

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Platforms and techniques used for biomarker assays: where are we now?

Bioanalysis, 2017-07, Vol.9 (14), p.1029-1031

2017

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Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues

Native high-resolution mass spectrometry analysis of noncovalent protein complexes up to 450 kDa

Systematic optimization of targeted and multiplexed MS-based screening workflows for protein biomarkers

Microvilli Morphology Can Affect Efflux Active P-Glycoprotein in Confluent MDCKII -hMDR1-NKI and Caco-2 Cell Monolayers

Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency

Application of high-resolution MS for development of peptide and large-molecule drug candidates

Development of a highly sensitive and selective UPLC/MS/MS method for the simultaneous determination of testosterone and 5α-dihydrotestosterone in human serum to support testosterone replacement therapy for hypogonadism

Microflow UPLC and high-resolution MS as a sensitive and robust platform for quantitation of intact peptide hormones

Covalent Adduction of Human Serum Albumin by 4-Hydroxy-2-Nonenal: Kinetic Analysis of Competing Alkylation Reactions

Intact mAb LC–MS for drug concentration from pre-clinical studies: bioanalytical method performance and in-life samples

A new era for proteomics

Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression

Identification of Proteins Adducted by Lipid Peroxidation Products in Plasma and Modifications of Apolipoprotein A1 with a Novel Biotinylated Phospholipid Probe

Integrating internal and external bioanalytical support to deliver a diversified pharmaceutical portfolio

The Gyrolab™ immunoassay system: a platform for automated bioanalysis and rapid sample turnaround

Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1

Comparison of the quantification of a therapeutic protein using nominal and accurate mass MS/MS

Absolute quantification of a therapeutic domain antibody using ultra-performance liquid chromatography-mass spectrometry and immunoassay

Phospholipid−Protein Adducts of Lipid Peroxidation: Synthesis and Study of New Biotinylated Phosphatidylcholines

Quantitative immunocapture MS: current status and challenges in drug discovery

Improved Sensitivity for Protein Turnover Quantification by Monitoring Immonium Ion Isotopologue Abundance

The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF

Ocular tissue distribution and pharmacokinetic study of a small 13kDa domain antibody after intravitreal, subconjuctival and eye drop administration in rabbits

Platforms and techniques used for biomarker assays: where are we now?

2019 White Paper on Recent Issues in Bioanalysis: Chromatographic Assays (Part 1 – Innovation in Small Molecules and Oligonucleotides & Mass Spectrometric Method Development Strategies for Large Molecule Bioanalysis)

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