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Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

Chemical reviews, 2014-06, Vol.114 (11), p.5753-5774

2014

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Characterization of Disease-Associated Mutations in Human Transmembrane Proteins

PloS one, 2016-03, Vol.11 (3), p.e0151760-e0151760

2016

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Conversion of chemical to mechanical energy by the nucleotide binding domains of ABCB1

Scientific reports, 2020-02, Vol.10 (1), p.2589-2589, Article 2589

2020

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ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia

Nature communications, 2023-09, Vol.14 (1), p.5709-16, Article 5709

2023

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Nucleotide binding is the critical regulator of ABCG2 conformational transitions

eLife, 2023-02, Vol.12

2023

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Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein-Expressing Cells

Cancer research (Chicago, Ill.), 2020-02, Vol.80 (4), p.663-674

2020

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Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases

Dalton transactions : an international journal of inorganic chemistry, 2018-12, Vol.47 (47), p.17032-17045

2018

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Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells

BMC cancer, 2018-10, Vol.18 (1), p.1029-1029, Article 1029

2018

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Mesenchymal Stem Cells Increase Drug Tolerance of A431 Cells Only in 3D Spheroids, Not in 2D Co-Cultures

International journal of molecular sciences, 2024-04, Vol.25 (8), p.4515

2024

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Efficient Synthesis of Acylated, Dialkyl α-Hydroxy-Benzylphosphonates and Their Anticancer Activity

Molecules (Basel, Switzerland), 2022-03, Vol.27 (7), p.2067

2022

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Modified β-cyclodextrin inclusion complex to improve the physicochemical properties of albendazole. complete in vitro evaluation and characterization

PloS one, 2014-02, Vol.9 (2), p.e88234-e88234

2014

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Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion

PLoS genetics, 2020-10, Vol.16 (10), p.e1009016-e1009016

2020

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5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice

PloS one, 2018-01, Vol.13 (1), p.e0189593-e0189593

2018

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Synthesis and Anticancer Cytotoxicity of Azaaurones Overcoming Multidrug Resistance

Molecules (Basel, Switzerland), 2020-02, Vol.25 (3), p.764

2020

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Nonequilibrium population dynamics of phenotype conversion of cancer cells

PloS one, 2014-12, Vol.9 (12), p.e110714-e110714

2014

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Characterisation of Canine and Feline Breast Tumours, Their Metastases, and Corresponding Primary Cell Lines Using LA-REIMS and DESI-MS Imaging

International journal of molecular sciences, 2024-07, Vol.25 (14), p.7752

2024

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Pegylated liposomal formulation of doxorubicin overcomes drug resistance in a genetically engineered mouse model of breast cancer

Journal of controlled release, 2017-09, Vol.261, p.287-296

2017

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An inventory of lysosomal ABC transporters

FEBS letters, 2020-12, Vol.594 (23), p.3965-3985

2020

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The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition

Cell death & disease, 2018-10, Vol.9 (11), p.1-17, Article 1052

2018

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Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis

Molecular pharmacology, 2017-10, Vol.92 (4), p.401-413

2017

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Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes

PloS one, 2012-05, Vol.7 (5), p.e37378-e37378

2012

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Metal Complexes of a 5-Nitro-8-Hydroxyquinoline-Proline Hybrid with Enhanced Water Solubility Targeting Multidrug Resistant Cancer Cells

International journal of molecular sciences, 2022-12, Vol.24 (1), p.593

2022

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Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography

Clinical pharmacology and therapeutics, 2018-07, Vol.104 (1), p.139-147

2018

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A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions

PloS one, 2018-01, Vol.13 (1), p.e0190629

2018

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Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

Characterization of Disease-Associated Mutations in Human Transmembrane Proteins

Conversion of chemical to mechanical energy by the nucleotide binding domains of ABCB1

ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia

Nucleotide binding is the critical regulator of ABCG2 conformational transitions

Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein-Expressing Cells

Copper(II) Complexes with Isomeric Morpholine-Substituted 2‑Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters

Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases

Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells

Mesenchymal Stem Cells Increase Drug Tolerance of A431 Cells Only in 3D Spheroids, Not in 2D Co-Cultures

Efficient Synthesis of Acylated, Dialkyl α-Hydroxy-Benzylphosphonates and Their Anticancer Activity

Modified β-cyclodextrin inclusion complex to improve the physicochemical properties of albendazole. complete in vitro evaluation and characterization

Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion

5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice

Synthesis and Anticancer Cytotoxicity of Azaaurones Overcoming Multidrug Resistance

Nonequilibrium population dynamics of phenotype conversion of cancer cells

Characterisation of Canine and Feline Breast Tumours, Their Metastases, and Corresponding Primary Cell Lines Using LA-REIMS and DESI-MS Imaging

Pegylated liposomal formulation of doxorubicin overcomes drug resistance in a genetically engineered mouse model of breast cancer

An inventory of lysosomal ABC transporters

The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition

Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis

Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes

Metal Complexes of a 5-Nitro-8-Hydroxyquinoline-Proline Hybrid with Enhanced Water Solubility Targeting Multidrug Resistant Cancer Cells

Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions

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