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Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery

Antimicrobial agents and chemotherapy, 2017-09, Vol.61 (9)

2017

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Screening a Natural Product-Based Library against Kinetoplastid Parasites

Molecules (Basel, Switzerland), 2017-10, Vol.22 (10), p.1715

2017

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Approaches to protozoan drug discovery: phenotypic screening

Journal of medicinal chemistry, 2013-10, Vol.56 (20), p.7727-7740

2013

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The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

Organic & biomolecular chemistry, 2019-07, Vol.17 (28), p.679-6798

2019

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Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign

PLoS neglected tropical diseases, 2012-11, Vol.6 (11), p.e1896

2012

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3-pyridyl inhibitors with novel activity against Trypanosoma cruzi reveal in vitro profiles can aid prediction of putative cytochrome P450 inhibition

Scientific reports, 2018-03, Vol.8 (1), p.4901-12, Article 4901

2018

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Impact of Laboratory-Adapted Intracellular Trypanosoma cruzi Strains on the Activity Profiles of Compounds with Anti- T. cruzi Activity

Microorganisms (Basel), 2023-02, Vol.11 (2), p.476

2023

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Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427

The American journal of tropical medicine and hygiene, 2009-10, Vol.81 (4), p.665

2009

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Trypanocidal activity of marine natural products

Marine Drugs, 2013-10, Vol.11 (10), p.4058-4082

2013

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Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes

International journal for parasitology -- drugs and drug resistance, 2015-12, Vol.5 (3), p.215-228

2015

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Antitubercular and Antiparasitic 2‑Nitroimidazopyrazinones with Improved Potency and Solubility

Journal of medicinal chemistry, 2020-12, Vol.63 (24), p.15726-15751

2020

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Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism

European journal of medicinal chemistry, 2024-03, Vol.268, p.116162-116162, Article 116162

2024

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Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites

PLoS neglected tropical diseases, 2020-03, Vol.14 (3), p.e0008068-e0008068

2020

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Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection

Journal of medicinal chemistry, 2022-10, Vol.65 (19), p.13125-13142

2022

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Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides

RSC medicinal chemistry, 2020-06, Vol.11 (6), p.685-695

2020

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Design, Synthesis, and Biological Evaluation of 2‑Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity

Journal of medicinal chemistry, 2018-12, Vol.61 (24), p.11349-11371

2018

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Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia

International journal of antimicrobial agents, 2010-09, Vol.36 (3), p.275-279

2010

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Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy

European journal of medicinal chemistry, 2020-12, Vol.207, p.112849, Article 112849

2020

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A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427

Parasites & vectors, 2009-11, Vol.2 (1), p.54-54

2009

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Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both Trypanosoma cruzi and Trypanosoma brucei

Microorganisms (Basel), 2022-06, Vol.10 (7), p.1287

2022

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Total Synthesis of the Antimalarial Ascidian Natural Product Albopunctatone

Organic letters, 2019-07, Vol.21 (14), p.5519-5523

2019

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Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6393-6402

2014

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Thieno[3,2-b]pyrrole 5-carboxamides as potent and selective inhibitors of Giardia duodenalis

International journal for parasitology -- drugs and drug resistance, 2023-12, Vol.23, p.54-62

2023

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6‑Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6753-6765

2015

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Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

Parasites & vectors, 2016-11, Vol.9 (1), p.589-589, Article 589

2016

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Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery

Screening a Natural Product-Based Library against Kinetoplastid Parasites

Approaches to protozoan drug discovery: phenotypic screening

The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign

3-pyridyl inhibitors with novel activity against Trypanosoma cruzi reveal in vitro profiles can aid prediction of putative cytochrome P450 inhibition

Impact of Laboratory-Adapted Intracellular Trypanosoma cruzi Strains on the Activity Profiles of Compounds with Anti- T. cruzi Activity

Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427

Trypanocidal activity of marine natural products

Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes

Antitubercular and Antiparasitic 2‑Nitroimidazopyrazinones with Improved Potency and Solubility

Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism

Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites

Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection

Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides

Design, Synthesis, and Biological Evaluation of 2‑Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity

Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia

Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy

A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427

Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both Trypanosoma cruzi and Trypanosoma brucei

Total Synthesis of the Antimalarial Ascidian Natural Product Albopunctatone

Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Thieno[3,2-b]pyrrole 5-carboxamides as potent and selective inhibitors of Giardia duodenalis

6‑Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

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