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How were new medicines discovered?

Nature reviews. Drug discovery, 2011-07, Vol.10 (7), p.507-519

2011

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Why medicines work

Pharmacology & therapeutics (Oxford), 2022-10, Vol.238, p.108175-108175, Article 108175

Swinney, David C.

2022

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Fluxes for Unraveling Complex Binding Mechanisms

Trends in pharmacological sciences (Regular ed.), 2020-12, Vol.41 (12), p.923-932

2020

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The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines

Journal of biomolecular screening, 2013-12, Vol.18 (10), p.1186-1192

Swinney, David C

2013

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Neglected Tropical Diseases: Drug Discovery and Development

1, 2019

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Biochemical mechanisms of drug action: what does it take for success?

Nature reviews. Drug discovery, 2004-09, Vol.3 (9), p.801-808

Swinney, David C

2004

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The Role of Binding Kinetics in GPCR Drug Discovery

Current topics in medicinal chemistry, 2015-01, Vol.15 (24), p.2504-2522

2015

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Recent advances in phenotypic drug discovery [version 1; peer review: 2 approved]

F1000 research, 2020, Vol.9, p.944

2020

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Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and safety

Current topics in medicinal chemistry, 2006-03, Vol.6 (5), p.461-478

Swinney, David C

2006

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Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates

Current drug discovery technologies, 2016-03, Vol.13 (1), p.2-15

2016

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The value of translational biomarkers to phenotypic assays

Frontiers in pharmacology, 2014-07, Vol.5, p.171-171

Swinney, David C

2014

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A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

British journal of pharmacology, 2014-07, Vol.171 (14), p.3364-3375

2014

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On the different experimental manifestations of two‐state ‘induced‐fit’ binding of drugs to their cellular targets

British journal of pharmacology, 2016-04, Vol.173 (8), p.1268-1285

2016

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Response of anterior temporal cortex to syntactic and prosodic manipulations during sentence processing

Human brain mapping, 2005-10, Vol.26 (2), p.128-138

2005

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Transcriptomic analysis of the woodchuck model of chronic hepatitis B

Hepatology (Baltimore, Md.), 2012-09, Vol.56 (3), p.820-830

2012

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A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β

PLoS neglected tropical diseases, 2016-03, Vol.10 (3), p.e0004506-e0004506

2016

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Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B

PLoS pathogens, 2015-09, Vol.11 (9), p.e1005103

2015

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Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY

The Journal of biological chemistry, 2011-01, Vol.286 (3), p.2067-2077

2011

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The discovery of medicines for rare diseases

Future medicinal chemistry, 2014-06, Vol.6 (9), p.987-1002

2014

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Contrasting Roles of Mitogen-Activated Protein Kinases in Cellular Entry and Replication of Hepatitis C Virus: MKNK1 Facilitates Cell Entry

Journal of Virology, 2013-04, Vol.87 (8), p.4214-4224

2013

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Cigarette Smoke Synergistically Enhances Respiratory Mucin Induction by Proinflammatory Stimuli

American journal of respiratory cell and molecular biology, 2006-08, Vol.35 (2), p.165-174

2006

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Can Binding Kinetics Translate to a Clinically Differentiated Drug? From Theory to Practice

Letters in drug design & discovery, 2006-10, Vol.3 (8), p.569-574

Swinney, David

2006

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Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)

SLAS discovery, 2020-01, Vol.25 (1), p.33-42

2020

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The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance

Journal of pharmaceutical sciences, 2014-11, Vol.103 (11), p.3377-3397

2014

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Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity

The Journal of biological chemistry, 2008-04, Vol.283 (14), p.9488-9496

2008

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How were new medicines discovered?

Why medicines work

Fluxes for Unraveling Complex Binding Mechanisms

The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines

Neglected Tropical Diseases: Drug Discovery and Development

Biochemical mechanisms of drug action: what does it take for success?

The Role of Binding Kinetics in GPCR Drug Discovery

Recent advances in phenotypic drug discovery [version 1; peer review: 2 approved]

Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and safety

Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates

The value of translational biomarkers to phenotypic assays

A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

On the different experimental manifestations of two‐state ‘induced‐fit’ binding of drugs to their cellular targets

Response of anterior temporal cortex to syntactic and prosodic manipulations during sentence processing

Transcriptomic analysis of the woodchuck model of chronic hepatitis B

A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β

Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY

The discovery of medicines for rare diseases

Contrasting Roles of Mitogen-Activated Protein Kinases in Cellular Entry and Replication of Hepatitis C Virus: MKNK1 Facilitates Cell Entry

Cigarette Smoke Synergistically Enhances Respiratory Mucin Induction by Proinflammatory Stimuli

Can Binding Kinetics Translate to a Clinically Differentiated Drug? From Theory to Practice

Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)

The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance

Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity

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