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Turning the spotlight on the C11-oxy androgens in human fetal development

The Journal of steroid biochemistry and molecular biology, 2021-09, Vol.212, p.105946-105946, Article 105946

2021

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C11-hydroxy and C11-oxo C19 and C21 Steroids: Pre-Receptor Regulation and Interaction with Androgen and Progesterone Steroid Receptors

International journal of molecular sciences, 2024-01, Vol.25 (1), p.101

2024

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Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens

Scientific reports, 2024-07, Vol.14 (1), p.16226-11, Article 16226

2024

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Rooibos flavonoids inhibit the activity of key adrenal steroidogenic enzymes, modulating steroid hormone levels in H295R cells

Molecules (Basel, Switzerland), 2014-03, Vol.19 (3), p.3681-3695

2014

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The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells

The Journal of steroid biochemistry and molecular biology, 2012-02, Vol.128 (3-5), p.128-138

2012

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11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function

Molecules (Basel, Switzerland), 2013-10, Vol.18 (11), p.13228-13244

2013

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The Effect of Soy Isoflavones on Steroid Metabolism

Frontiers in endocrinology (Lausanne), 2019-04, Vol.10, p.229-229

2019

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Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C 19 steroids as the predominant androgens in prostate cancer

Molecular and cellular endocrinology, 2018-02, Vol.461, p.265

2018

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Back where it belongs: 11β-hydroxyandrostenedione compels the re-assessment of C11-oxy androgens in steroidogenesis

Molecular and cellular endocrinology, 2021-04, Vol.525, p.111189-111189, Article 111189

2021

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The 11β-hydroxyandrostenedione pathway and C11-oxy C21 backdoor pathway are active in benign prostatic hyperplasia yielding 11keto-testosterone and 11keto-progesterone

The Journal of steroid biochemistry and molecular biology, 2020-02, Vol.196, p.105497-105497, Article 105497

2020

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11 beta -Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?

Molecular and cellular endocrinology, 2013-09, Vol.377 (1-2), p.135-146

2013

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The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C 19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

The Journal of steroid biochemistry and molecular biology, 2019-05, Vol.189, p.116

2019

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Adrenal C11-oxy C 21 steroids contribute to the C11-oxy C 19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone

The Journal of steroid biochemistry and molecular biology, 2017-11, Vol.174, p.86

2017

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CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway

The Journal of steroid biochemistry and molecular biology, 2020-05, Vol.199, p.105614-105614, Article 105614

2020

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Discovery of Compound A--a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity

Oncotarget, 2015-10, Vol.6 (31), p.30730-30744

2015

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The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway

The Journal of steroid biochemistry and molecular biology, 2018-04, Vol.178, p.203-212

2018

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11β-hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways

Molecular and cellular endocrinology, 2015-06, Vol.408, p.114-123

2015

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11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?

Molecular and cellular endocrinology, 2013-09, Vol.377 (1-2), p.135-146

2013

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Ultra-performance convergence chromatography tandem mass spectrometry analysis of adrenal and gonadal steroid hormones in southern white rhinoceros(Ceratotherium simum simum) faeces and serum

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2023-01, Vol.1215, p.123576-123576, Article 123576

2023

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Rooibos (Aspalathus linearis) facilitates an anti-inflammatory state, modulating IL-6 and IL-10 while not inhibiting the acute glucocorticoid response to a mild novel stressor in vivo

Journal of functional foods, 2016-12, Vol.27, p.42-54

2016

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Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C19 steroids as the predominant androgens in prostate cancer

Molecular and cellular endocrinology, 2018-02, Vol.461, p.265-276

2018

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11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

The Journal of steroid biochemistry and molecular biology, 2019-07, Vol.191, p.105369-105369, Article 105369

2019

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Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas

The Journal of steroid biochemistry and molecular biology, 2015-09, Vol.153, p.80-92

2015

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Steroid hormone analysis of adolescents and young women with polycystic ovarian syndrome and adrenocortical dysfunction using UPC2-MS/MS

Pediatric research, 2021-01, Vol.89 (1), p.118-126

2021

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11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione

The Journal of steroid biochemistry and molecular biology, 2013-11, Vol.138, p.132-142

2013

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Turning the spotlight on the C11-oxy androgens in human fetal development

C11-hydroxy and C11-oxo C19 and C21 Steroids: Pre-Receptor Regulation and Interaction with Androgen and Progesterone Steroid Receptors

Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens

Rooibos flavonoids inhibit the activity of key adrenal steroidogenic enzymes, modulating steroid hormone levels in H295R cells

The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells

11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function

The Effect of Soy Isoflavones on Steroid Metabolism

Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C 19 steroids as the predominant androgens in prostate cancer

Back where it belongs: 11β-hydroxyandrostenedione compels the re-assessment of C11-oxy androgens in steroidogenesis

The 11β-hydroxyandrostenedione pathway and C11-oxy C21 backdoor pathway are active in benign prostatic hyperplasia yielding 11keto-testosterone and 11keto-progesterone

11 beta -Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?

The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C 19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

Adrenal C11-oxy C 21 steroids contribute to the C11-oxy C 19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone

CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway

Discovery of Compound A--a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity

The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway

11β-hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways

11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?

Ultra-performance convergence chromatography tandem mass spectrometry analysis of adrenal and gonadal steroid hormones in southern white rhinoceros(Ceratotherium simum simum) faeces and serum

Rooibos (Aspalathus linearis) facilitates an anti-inflammatory state, modulating IL-6 and IL-10 while not inhibiting the acute glucocorticoid response to a mild novel stressor in vivo

Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C19 steroids as the predominant androgens in prostate cancer

11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas

Steroid hormone analysis of adolescents and young women with polycystic ovarian syndrome and adrenocortical dysfunction using UPC2-MS/MS

11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione

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