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Impact of GPCR Structures on Drug Discovery

Cell, 2020-04, Vol.181 (1), p.81-91

2020

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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (29), p.E2724-E2732

2013

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Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7029-7042

2017

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A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation

Tetrahedron letters, 2011-11, Vol.52 (45), p.6000-6002

2011

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Recent progress in sodium channel modulators for pain

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3690-3699

2014

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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.593-624

2013

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Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: A novel histamine H4 receptor antagonist

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6596-6602

2011

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A Versatile Stereoselective Synthesis of endo,exo-Furofuranones: Application to the Enantioselective Synthesis of Furofuran Lignans

Journal of organic chemistry, 2004-01, Vol.69 (1), p.122-129

2004

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Voltage gated sodium channels as drug discovery targets

Channels (Austin, Tex.), 2015-11, Vol.9 (6), p.360-366

2015

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Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ‑Opioid Receptor

Journal of chemical information and modeling, 2021-07, Vol.61 (7), p.3696-3707

2021

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Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes

Bioorganic & medicinal chemistry letters, 2017-11, Vol.27 (21), p.4805-4811

2017

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The role of organic anion‐transporting polypeptides and formulation in the clearance and distribution of a novel Nav1.7 channel blocker

Biopharmaceutics & drug disposition, 2018-09, Vol.39 (8), p.388-393

2018

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The role of organic anion-transporting polypeptides and formulation in the clearance and distribution of a novel Na v 1.7 channel blocker

Biopharmaceutics & drug disposition, 2018-09, Vol.39 (8), p.388-393

2018

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Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

MedChemComm, 2010-12, Vol.1 (5), p.309-318

2010

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Discovery of a Series of Indazole TRPA1 Antagonists

ACS medicinal chemistry letters, 2017-06, Vol.8 (6), p.666-671

2017

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Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays

Journal of medicinal chemistry, 2009-02, Vol.52 (4), p.1219-1223

2009

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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7029-7042

2017

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Synthesis of novel histamine H4 receptor antagonists

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1156-1159

2012

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An Ammonia-Triggered Stereocontrolled Conversion of a γ-Lactone to the Central Tetrahydropyran of Pederin, Psymberin, and Onnamides D-F

European Journal of Organic Chemistry, 2012-02, Vol.2012 (6), p.1217-1222

2012

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C−H Insertion Approach to the Synthesis of endo,exo-Furofuranones: Synthesis of (±)-Asarinin, (±)-Epimagnolin A, and (±)-Fargesin

Journal of organic chemistry, 2001-10, Vol.66 (20), p.6719-6728

2001

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An efficient synthesis of endo,exo-furofuranone derivatives

Chemical communications (Cambridge, England), 2002-09 (18), p.2042-2043

2002

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A Versatile Stereoselective Synthesis of e ndo, e xo-Furofuranones: Application to the Enantioselective Synthesis of Furofuran Lignans

Journal of organic chemistry, 2004-01, Vol.69 (1), p.122-129

2004

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Intramolecular C-H insertions adjacent to sulfur for the diastereoselective synthesis of thienofuranones

Chemical communications (Cambridge, England), 2004-01 (15), p.1772-1773

2004

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Corrigendum to “A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation” [Tetrahedron Lett. 52 (2011) 6000]

Tetrahedron letters, 2012-04, Vol.53 (17), p.2260-2260

2012

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Impact of GPCR Structures on Drug Discovery

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation

Recent progress in sodium channel modulators for pain

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: A novel histamine H4 receptor antagonist

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

A Versatile Stereoselective Synthesis of endo,exo-Furofuranones: Application to the Enantioselective Synthesis of Furofuran Lignans

Voltage gated sodium channels as drug discovery targets

Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ‑Opioid Receptor

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes

The role of organic anion‐transporting polypeptides and formulation in the clearance and distribution of a novel Nav1.7 channel blocker

The role of organic anion-transporting polypeptides and formulation in the clearance and distribution of a novel Na v 1.7 channel blocker

Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

Discovery of a Series of Indazole TRPA1 Antagonists

Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7

Synthesis of novel histamine H4 receptor antagonists

An Ammonia-Triggered Stereocontrolled Conversion of a γ-Lactone to the Central Tetrahydropyran of Pederin, Psymberin, and Onnamides D-F

C−H Insertion Approach to the Synthesis of endo,exo-Furofuranones: Synthesis of (±)-Asarinin, (±)-Epimagnolin A, and (±)-Fargesin

An efficient synthesis of endo,exo-furofuranone derivatives

A Versatile Stereoselective Synthesis of e ndo, e xo-Furofuranones: Application to the Enantioselective Synthesis of Furofuran Lignans

Intramolecular C-H insertions adjacent to sulfur for the diastereoselective synthesis of thienofuranones

Corrigendum to “A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation” [Tetrahedron Lett. 52 (2011) 6000]

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