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In Vitro and In Silico Characterization of Lemborexant (E2006), a Novel Dual Orexin Receptor Antagonist

The Journal of pharmacology and experimental therapeutics, 2017-08, Vol.362 (2), p.287-295

2017

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Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation

Sleep (New York, N.Y.), 2019-06, Vol.42 (6), p.1

2019

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Deep-red fluorogenic cyanine dyes carrying an amino group-terminated side chain for improved RNA detection and nucleolar RNA imaging

RSC advances, 2021-11, Vol.11 (56), p.35436-35439

2021

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Discovery of (1R,2S)‑2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)‑N‑(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist

Journal of medicinal chemistry, 2015-06, Vol.58 (11), p.4648-4664

2015

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Bright and Light-Up Sensing of Benzo[c,d]indole-oxazolopyridine Cyanine Dye for RNA and Its Application to Highly Sensitive Imaging of Nucleolar RNA in Living Cells

ACS omega, 2022-07, Vol.7 (27), p.23744-23748

2022

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Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin‑2 Receptor

Journal of medicinal chemistry, 2013-08, Vol.56 (16), p.6371-6385

2013

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Orexin-A (hypocretin-1) is possibly involved in generation of anxiety-like behavior

Brain research, 2005-05, Vol.1044 (1), p.116-121

2005

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A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder

PloS one, 2013-09, Vol.8 (9), p.e75040

2013

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Dual involvement of G-substrate in motor learning revealed by gene deletion

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (9), p.3525-3530

2009

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Disposition and Metabolism of [ 14 C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites

Drug metabolism and disposition, 2021-01, Vol.49 (1), p.31-38

2021

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Cationic Oligopeptides with Amino Groups as Synthetic Nucleolar Localization Signals for the Rational Design of Nucleolus-Staining Probes

ACS omega, 2023-03, Vol.8 (10), p.9592-9596

2023

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Age-dependent impairment of delay and trace eyeblink conditioning in mice

Neuroreport, 2001-10, Vol.12 (15), p.3349-3352

2001

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Spin dynamics phenomena of a cerium() double-decker complex induced by intramolecular electron transfer

Dalton transactions : an international journal of inorganic chemistry, 2024-07, Vol.53 (28), p.11664-11677

2024

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Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists

Bioorganic & medicinal chemistry, 2014-11, Vol.22 (21), p.6071-6088

2014

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Development of Novel PET Probes for Central 2‑Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors

Journal of medicinal chemistry, 2015-11, Vol.58 (21), p.8444-8462

2015

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Fluorogenic Monomethine Cyanine Dyes for Nucleolar RNA Imaging in Living Cells

BUNSEKI KAGAKU, 2024/03/05, Vol.73(3), pp.79-86

2024

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モノメチンシアニン蛍光色素による生細胞核小体RNAイメージング

分析化学, 2024/03/05, Vol.73(3), pp.79-86

2024

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Corrigendum to “Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists” [Bioorg. Med. Chem. 22 (2014) 6071–6088]

Bioorganic & medicinal chemistry, 2015-07, Vol.23 (13), p.3870-3870

2015

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Classical eyeblink conditioning in glutamate receptor subunit δ2 mutant mice is impaired in the delay paradigm but not in the trace paradigm

The European journal of neuroscience, 2001-03, Vol.13 (6), p.1249-1253

2001

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P1-7-2 An evaluation of the utility of preclinical PK/PD analysis using small-animal PET in drug discovery process

Journal of Pharmacological Sciences, 2014-02, Vol.124 (suppl), p.155-155

2014

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O1F-3-5 Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin-2 Receptor

Journal of Pharmacological Sciences, 2014-02, Vol.124 (suppl), p.77-77

2014

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Classical eyeblink conditioning in glutamate receptor subunit delta 2 mutant mice is impaired in the delay paradigm but not in the trace paradigm

The European journal of neuroscience, 2001-03, Vol.13 (6), p.1249-1253

2001

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FEM Formulation and Strength Simulation by Interfacial Contact Model of Fiber-Reinforced Ceramic Matric Composites

Nihon Fukugō Zairyō Gakkaishi, 2005, Vol.31 (4), p.184-191

2005

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Age-dependent impairment of delay and trace eyeblink conditioning in mice

Neuroreport, 2001-10, Vol.12 (15), p.3349-3352

2001

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Fabrication and High-Temperature Flexural Strength of a Sintered SiC Fiber Reinforced SiC Composite

Zairyō, 2003, Vol.52 (6), p.681-687

2003

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In Vitro and In Silico Characterization of Lemborexant (E2006), a Novel Dual Orexin Receptor Antagonist

Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation

Deep-red fluorogenic cyanine dyes carrying an amino group-terminated side chain for improved RNA detection and nucleolar RNA imaging

Discovery of (1R,2S)‑2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)‑N‑(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist

Bright and Light-Up Sensing of Benzo[c,d]indole-oxazolopyridine Cyanine Dye for RNA and Its Application to Highly Sensitive Imaging of Nucleolar RNA in Living Cells

Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin‑2 Receptor

Orexin-A (hypocretin-1) is possibly involved in generation of anxiety-like behavior

A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder

Dual involvement of G-substrate in motor learning revealed by gene deletion

Disposition and Metabolism of [ 14 C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites

Cationic Oligopeptides with Amino Groups as Synthetic Nucleolar Localization Signals for the Rational Design of Nucleolus-Staining Probes

Age-dependent impairment of delay and trace eyeblink conditioning in mice

Spin dynamics phenomena of a cerium() double-decker complex induced by intramolecular electron transfer

Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists

Development of Novel PET Probes for Central 2‑Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors

Fluorogenic Monomethine Cyanine Dyes for Nucleolar RNA Imaging in Living Cells

モノメチンシアニン蛍光色素による生細胞核小体RNAイメージング

Corrigendum to “Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists” [Bioorg. Med. Chem. 22 (2014) 6071–6088]

Classical eyeblink conditioning in glutamate receptor subunit δ2 mutant mice is impaired in the delay paradigm but not in the trace paradigm

P1-7-2 An evaluation of the utility of preclinical PK/PD analysis using small-animal PET in drug discovery process

O1F-3-5 Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin-2 Receptor

Classical eyeblink conditioning in glutamate receptor subunit delta 2 mutant mice is impaired in the delay paradigm but not in the trace paradigm

FEM Formulation and Strength Simulation by Interfacial Contact Model of Fiber-Reinforced Ceramic Matric Composites

Age-dependent impairment of delay and trace eyeblink conditioning in mice

Fabrication and High-Temperature Flexural Strength of a Sintered SiC Fiber Reinforced SiC Composite

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