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RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist

PloS one, 2013-12, Vol.8 (12), p.e83190

2013

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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Nature communications, 2021-02, Vol.12 (1), p.1222-1222, Article 1222

2021

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Enabling structure-based drug discovery utilizing predicted models

Cell, 2024-02, Vol.187 (3), p.521-525

2024

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RVX-297- a novel BD2 selective inhibitor of BET bromodomains

Biochemical and biophysical research communications, 2016-08, Vol.477 (1), p.62-67

2016

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Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions

The EMBO journal, 2001-09, Vol.20 (18), p.5207-5218

2001

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Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16773-16795

2024

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Structure–Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch

ACS chemical biology, 2018-10, Vol.13 (10), p.2908-2919

2018

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Crystal structure of a nucleosome core particle containing the variant histone H2A.Z

Nature structural & molecular biology, 2000-12, Vol.7 (12), p.1121-1124

2000

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Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine

Journal of medicinal chemistry, 2018-09, Vol.61 (18), p.8202-8211

2018

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The identification of highly efficacious functionalised tetrahydrocyclopenta[]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly

RSC medicinal chemistry, 2022-03, Vol.13 (3), p.343-349

2022

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Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors

ACS bio & med chem au, 2023-12, Vol.3 (6), p.507-515

2023

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Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design

Bioorganic & medicinal chemistry letters, 2015-07, Vol.25 (14), p.2818-2823

2015

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Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-binding Ligands

Journal of molecular biology, 2003-02, Vol.326 (2), p.371-380

2003

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Sequence-specific Recognition of DNA in the Nucleosome by Pyrrole-Imidazole Polyamides

Journal of molecular biology, 2001-06, Vol.309 (3), p.615-629

2001

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Synthesis, Characterization, Solution Stability, and X-ray Crystal Structure of the Thiolatocobalamin γ-Glutamylcysteinylcobalamin, a Dipeptide Analogue of Glutathionylcobalamin: Insights into the Enhanced Co−S Bond Stability of the Natural Product Glutathionylcobalamin

Inorganic chemistry, 2001-06, Vol.40 (12), p.2686-2692

2001

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Structure and dynamics of nucleosomal DNA

Biopolymers, 2003-04, Vol.68 (4), p.547-556

2003

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Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity

The Journal of biological chemistry, 2010-04, Vol.285 (16), p.12169-12180

2010

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Structure-activity relationship of flavin analogs that target the FMN riboswitch

ACS chemical biology, 2018-09, Vol.13 (10), p.2908-2919

2018

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Conversion of D-Arabinose to D-Erythroascorbic Acid and Oxalic Acid in Sclerotinia sclerotiorum

Biochemical and biophysical research communications, 1995-07, Vol.212 (1), p.196-203

1995

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Ribonucleoside Triphosphate Reductase from Lactobacillus leichmannii: Kinetic Evaluation of a Series of Adenosylcobalamin Competitive Inhibitors, [ω-(Adenosin-5′-O-yl)alkyl]cobalamins, Which Mimic the Post Co-C Homolysis Intermediate

Bioorganic chemistry, 1999-12, Vol.27 (6), p.451-462

1999

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Synthesis of γ-Phosphate-Linked Nucleoside Affinity Chromatography Resins for Protein Purification, Including Ribonucleoside Triphosphate Reductase

Nucleosides & nucleotides, 1998-08, Vol.17 (8), p.1453-1471

1998

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Adenosylcobalamin-Dependent Ribonucleoside Triphosphate Reductase from Lactobacillus Leichmannii. Rapid, Improved Purification Involving dGTP-Based Affinity Chromatography Plus Biophysical Characterization Studies Demonstrating Enhanced, "Crystallographic Level" Purity

Preparative biochemistry & biotechnology, 1999-01, Vol.29 (3), p.273-309

1999

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Purification, mechanistic studies, and initial crystallization of the adenosylcobalamin-dependent ribonucleoside-triphosphate reductase from Lactobacillus leichmannii

Suto, Robert Keith

1998

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A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

Nature communications, 2021-07, Vol.12 (1), p.4358-4358, Article 4358

2021

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Global satellite observations of column-averaged carbon dioxide and methane: The GHG-CCI XCO2 and XCH4 CRDP3 data set

Remote sensing of environment, 2017-12, Vol.203, p.276-295

2017

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RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist

Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Enabling structure-based drug discovery utilizing predicted models

RVX-297- a novel BD2 selective inhibitor of BET bromodomains

Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions

Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836

Structure–Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch

Crystal structure of a nucleosome core particle containing the variant histone H2A.Z

Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine

The identification of highly efficacious functionalised tetrahydrocyclopenta[]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly

Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors

Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design

Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-binding Ligands

Sequence-specific Recognition of DNA in the Nucleosome by Pyrrole-Imidazole Polyamides

Synthesis, Characterization, Solution Stability, and X-ray Crystal Structure of the Thiolatocobalamin γ-Glutamylcysteinylcobalamin, a Dipeptide Analogue of Glutathionylcobalamin: Insights into the Enhanced Co−S Bond Stability of the Natural Product Glutathionylcobalamin

Structure and dynamics of nucleosomal DNA

Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity

Structure-activity relationship of flavin analogs that target the FMN riboswitch

Conversion of D-Arabinose to D-Erythroascorbic Acid and Oxalic Acid in Sclerotinia sclerotiorum

Ribonucleoside Triphosphate Reductase from Lactobacillus leichmannii: Kinetic Evaluation of a Series of Adenosylcobalamin Competitive Inhibitors, [ω-(Adenosin-5′-O-yl)alkyl]cobalamins, Which Mimic the Post Co-C Homolysis Intermediate

Synthesis of γ-Phosphate-Linked Nucleoside Affinity Chromatography Resins for Protein Purification, Including Ribonucleoside Triphosphate Reductase

Adenosylcobalamin-Dependent Ribonucleoside Triphosphate Reductase from Lactobacillus Leichmannii. Rapid, Improved Purification Involving dGTP-Based Affinity Chromatography Plus Biophysical Characterization Studies Demonstrating Enhanced, "Crystallographic Level" Purity

Purification, mechanistic studies, and initial crystallization of the adenosylcobalamin-dependent ribonucleoside-triphosphate reductase from Lactobacillus leichmannii

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

Global satellite observations of column-averaged carbon dioxide and methane: The GHG-CCI XCO2 and XCH4 CRDP3 data set

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