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Identification of Bile Acids Responsible for Inhibiting the Bile Salt Export Pump, Leading to Bile Acid Accumulation and Cell Toxicity in Rat Hepatocytes

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2412-2419

2017

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The PD1 inhibitory pathway and mature dendritic cells contribute to abacavir hypersensitivity in human leukocyte antigen transgenic PD1 knockout mice

Toxicology (Amsterdam), 2021-11, Vol.463, p.152971-152971, Article 152971

2021

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Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay

Drug metabolism and disposition, 2015-11, Vol.43 (11), p.1760-1768

2015

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HLA transgenic mice: application in reproducing idiosyncratic drug toxicity

Drug metabolism reviews, 2020-10, Vol.52 (4), p.540-567

2020

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Drug-induced altered self-presentation increases tumor immunogenicity

Biomedicine & pharmacotherapy, 2023-09, Vol.165, p.115241-115241, Article 115241

2023

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Establishment of a Drug-Induced, Bile Acid–Dependent Hepatotoxicity Model Using HepaRG Cells

Journal of pharmaceutical sciences, 2016-04, Vol.105 (4), p.1550-1560

2016

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Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity

Communications biology, 2021-09, Vol.4 (1), p.1137-1137, Article 1137

2021

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Calorie Restriction Impairs Anti-Tumor Immune Responses in an Immunogenic Preclinical Cancer Model

Nutrients, 2023-08, Vol.15 (16), p.3638

2023

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In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome

Drug metabolism and pharmacokinetics, 2019-08, Vol.34 (4), p.264-271

2019

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Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice

Archives of toxicology, 2018-03, Vol.92 (3), p.1177-1188

2018

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Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies

Cells (Basel, Switzerland), 2023-08, Vol.12 (16), p.2059

2023

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DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies

Cells (Basel, Switzerland), 2023-04, Vol.12 (7), p.1100

2023

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Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats

Xenobiotica, 2015-06, Vol.45 (6), p.556-562

2015

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An Animal Model of Abacavir-Induced HLA-Mediated Liver Injury

Toxicological sciences, 2018-04, Vol.162 (2), p.713-723

2018

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Mechanism-based integrated assay systems for the prediction of drug-induced liver injury

Toxicology and applied pharmacology, 2020-05, Vol.394, p.114958, Article 114958

2020

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Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice

Archives of toxicology, 2018-03, Vol.92 (3), p.1177-1188

2018

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γδT細胞はHLAクラスI欠損腫瘍に対する免疫療法で重要な役割を担う

ファルマシア, 2023, Vol.59(9), pp.868-868

薄田, 健史

2023

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カナダ・アルバータ州研究留学記

ファルマシア, 2023, Vol.59(8), pp.764-765

薄田, 健史

2023

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Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes

Toxicology in vitro, 2015-10, Vol.29 (7), p.1454-1463

2015

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Abstract 6391: Development of a novel strategy for cancer immunotherapy based on tumor immunogenicity improvement by HLA-drug interaction

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6391-6391

2023

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HLA-B57:01-dependent intracellular stress in keratinocytes triggers dermal hypersensitivity reactions to abacavir

PNAS nexus, 2024-04, Vol.3 (4), p.pgae140-pgae140

2024

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Establishment of a Drug-Induced, Bile Acid-Dependent Hepatotoxicity Model Using HepaRG Cells: Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism

Journal of pharmaceutical sciences, 2016-04, Vol.105 (4), p.1550-1560

2016

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Establishment of cholestatic drug-induced liver injury evaluation system in vitro using sandwich cultured human ips cell-derived hepatocytes

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S68-S68

2018

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P-47 Development of in vitro hepatotoxicity assessment system to predict the toxicological potential of cosmetic raw materials

Alternatives to Animal Testing and Experimentation, 2017-12, Vol.22 (suppl), p.78-78

2017

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P-38 Mechanism-oriented integrated in vitro assay systems : Alternative methods of systemic toxicity test

Alternatives to Animal Testing and Experimentation, 2016-12, Vol.21 (suppl), p.138-138

2016

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Identification of Bile Acids Responsible for Inhibiting the Bile Salt Export Pump, Leading to Bile Acid Accumulation and Cell Toxicity in Rat Hepatocytes

The PD1 inhibitory pathway and mature dendritic cells contribute to abacavir hypersensitivity in human leukocyte antigen transgenic PD1 knockout mice

Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay

HLA transgenic mice: application in reproducing idiosyncratic drug toxicity

Drug-induced altered self-presentation increases tumor immunogenicity

Establishment of a Drug-Induced, Bile Acid–Dependent Hepatotoxicity Model Using HepaRG Cells

Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity

Calorie Restriction Impairs Anti-Tumor Immune Responses in an Immunogenic Preclinical Cancer Model

In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome

Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice

Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies

DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies

Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats

An Animal Model of Abacavir-Induced HLA-Mediated Liver Injury

Mechanism-based integrated assay systems for the prediction of drug-induced liver injury

Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice

γδT細胞はHLAクラスI欠損腫瘍に対する免疫療法で重要な役割を担う

カナダ・アルバータ州研究留学記

Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes

Abstract 6391: Development of a novel strategy for cancer immunotherapy based on tumor immunogenicity improvement by HLA-drug interaction

HLA-B57:01-dependent intracellular stress in keratinocytes triggers dermal hypersensitivity reactions to abacavir

Establishment of a Drug-Induced, Bile Acid-Dependent Hepatotoxicity Model Using HepaRG Cells: Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism

Establishment of cholestatic drug-induced liver injury evaluation system in vitro using sandwich cultured human ips cell-derived hepatocytes

P-47 Development of in vitro hepatotoxicity assessment system to predict the toxicological potential of cosmetic raw materials

P-38 Mechanism-oriented integrated in vitro assay systems : Alternative methods of systemic toxicity test

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