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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Pain (Amsterdam), 2009-03, Vol.142 (1), p.27-35

2009

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Fibromyalgia: mechanisms, current treatment and animal models

Current pharmaceutical biotechnology, 2011-10, Vol.12 (10), p.1613-1626

2011

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SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1633-1638

2012

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A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid

The Journal of pharmacology and experimental therapeutics, 2005-07, Vol.314 (1), p.400-409

2005

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Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel

The Journal of general physiology, 2011-09, Vol.138 (3), p.341-352

2011

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(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.879-888

2008

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Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [ 3H]dopamine release

Neuropharmacology, 2005, Vol.48 (1), p.72-79

2005

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Central Pituitary Adenylate Cyclase 1 Receptors Modulate Nociceptive Behaviors in Both Inflammatory and Neuropathic Pain States

The journal of pain, 2008-05, Vol.9 (5), p.449-456

2008

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Nicotinic acetylcholine receptor-mediated [3H]dopamine release from hippocampus

The Journal of pharmacology and experimental therapeutics, 2005-03, Vol.312 (3), p.1298-1304

2005

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Acidification of Rat TRPV1 Alters the Kinetics of Capsaicin Responses

Molecular pain, 2005-09, Vol.1 (1), p.28-28

2005

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[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor

The Journal of pharmacology and experimental therapeutics, 2007-10, Vol.323 (1), p.285-293

2007

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Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets

Neuropharmacology, 2007-03, Vol.52 (4), p.1095-1105

2007

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Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.392-395

2008

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SAR of alpha 7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1633-1638

2012

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A Thallium Transport FLIPR-Based Assay for the Identification of KCC2-Positive Modulators

Journal of biomolecular screening, 2010-02, Vol.15 (2), p.177-184

2010

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Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists

Bioorganic & medicinal chemistry, 2008-09, Vol.16 (18), p.8516-8525

2008

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Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5493-5508

2007

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KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels

Journal of neuroscience methods, 2011-08, Vol.200 (1), p.54-62

2011

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Cracking the molecular weight barrier: Fragment screening of an aminotransferase using an NMR-based functional assay

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5248-5250

2011

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Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT

Assay and drug development technologies, 2013-02, Vol.11 (1), p.17-24

2013

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α-Methylation at benzylic fragment of N-aryl- N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3894-3899

2007

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Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels

Inflammation research, 2011-07, Vol.60 (7), p.683-693

2011

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Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels

Inflammation research, 2011-07, Vol.60 (7), p.683-693

2011

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A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase

Journal of neuroscience methods, 2007-03, Vol.161 (1), p.47-54

2007

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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Fibromyalgia: mechanisms, current treatment and animal models

SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore

A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid

Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel

(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo

Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [ 3H]dopamine release

Central Pituitary Adenylate Cyclase 1 Receptors Modulate Nociceptive Behaviors in Both Inflammatory and Neuropathic Pain States

Nicotinic acetylcholine receptor-mediated [3H]dopamine release from hippocampus

Acidification of Rat TRPV1 Alters the Kinetics of Capsaicin Responses

[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor

Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets

Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management

Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties

SAR of alpha 7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore

A Thallium Transport FLIPR-Based Assay for the Identification of KCC2-Positive Modulators

Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists

Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists

KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels

Cracking the molecular weight barrier: Fragment screening of an aminotransferase using an NMR-based functional assay

Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT

α-Methylation at benzylic fragment of N-aryl- N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model

Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels

Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels

A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase

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