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Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors

Pharmaceutics, 2022-10, Vol.14 (10), p.2233

2022

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From preclinical to clinical development: The example of a novel treatment for obesity

Neurobiology of disease, 2014-01, Vol.61, p.47-54

2014

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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4884-4901

2019

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Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors

Bioorganic & medicinal chemistry letters, 2021-07, Vol.43 (C), p.128058, Article 128058

2021

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Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1 H)ones as MCH-1 antagonists for the treatment of obesity

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7020-7023

2010

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Synthesis and SAR of vinca alkaloid analogues

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1245-1249

2009

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Stereo- and Regioselectivity of Pd0/InI-Mediated Allylic Additions to Aldehydes and Ketones. In Situ Generation of Allylindium(III) Intermediates from N-Acylnitroso Diels−Alder Cycloadducts and 1-Amino-4-acetoxycyclopentenes

Journal of organic chemistry, 2003-01, Vol.68 (1), p.139-149

2003

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Tetrahydrocarboline analogs as MCH-1 antagonists

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7024-7028

2010

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Stereo- and regioselectivity of Pd(0)/InI-mediated allylic additions to aldehydes and ketones. In situ generation of allylindium(III) intermediates from N-acylnitroso Diels-Alder cycloadducts and 1-amino-4-acetoxycyclopentenes

Journal of organic chemistry, 2003-01, Vol.68 (1), p.139-149

2003

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Regio- and Stereoselective Ring Openings of 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene Systems with Copper Catalyst-Modified Grignard Reagents: Application to the Synthesis of an Inhibitor of 5-Lipoxygenase

Journal of organic chemistry, 2002-06, Vol.67 (12), p.4115-4121

2002

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Preparation of Sitagliptin M2 and M5 metabolites and degradation impurities through a stereocontrolled amidine reduction

Tetrahedron letters, 2022-09, Vol.106, p.154058, Article 154058

2022

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Novel 1,4-Benzodiazepines from Acylnitroso-Derived Hetero-Diels−Alder Cycloadducts

Organic letters, 2002-01, Vol.4 (1), p.139-141

2002

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Synthesis of a Conformationally Restricted Substrate Analogue of Siderophore Biosynthetases

Organic letters, 2001-02, Vol.3 (4), p.519-521

2001

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Novel α-substituted β-amino diesters from acylnitroso-derived hetero-Diels–Alder cycloadducts

Tetrahedron letters, 2002-02, Vol.43 (7), p.1131-1134

2002

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Regio- and Stereoselective Fe(III)- and Pd(0)-Mediated Ring Openings of 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene Systems

Journal of organic chemistry, 1998-07, Vol.63 (15), p.4874-4875

1998

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Regio- and Stereochemically Controlled Formation of Hydroxamic Acid Containing a nti- or s yn-1,4-Cycloalkenols from Acylnitroso-Derived Diels−Alder Adducts

Journal of organic chemistry, 2001-04, Vol.66 (7), p.2466-2469

2001

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Regio- and Stereochemically Controlled Formation of Hydroxamic Acid Containing anti- or syn-1,4-Cycloalkenols from Acylnitroso-Derived Diels−Alder Adducts

Journal of organic chemistry, 2001-04, Vol.66 (7), p.2466-2469

2001

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The synthesis and SAR of novel diarylsulfone 11b-HSD1 inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7071-7075

2010

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Stereo- and Regioselectivity of Pd 0 /InI-Mediated Allylic Additions to Aldehydes and Ketones. In Situ Generation of Allylindium(III) Intermediates from N -Acylnitroso Diels−Alder Cycloadducts and 1-Amino-4-acetoxycyclopentenes

Journal of organic chemistry, 2003-01, Vol.68 (1), p.139-149

2003

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ChemInform Abstract: Regio- and Stereochemically Controlled Formation of Hydroxamic Acid Containing anti- or syn-1,4-Cycloalkenols from Acylnitroso-Derived Diels-Alder Adducts

ChemInform, 2001-08, Vol.32 (34), p.no-no

2001

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ChemInform Abstract: Novel 1,4-Benzodiazepines from Acylnitroso-Derived Hetero-Diels-Alder Cycloadducts

ChemInform, 2002-06, Vol.33 (22), p.no-no

2002

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ChemInform Abstract: Novel α-Substituted β-Amino Diesters from Acylnitroso-Derived Hetero-Diels-Alder Cycloadducts

ChemInform, 2002-05, Vol.33 (21), p.no-no

2002

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Stereo- and Regioselectivity of Pd0/InI-Mediated Allylic Additions to Aldehydes and Ketones. In situ Generation of Allylindium(III) Intermediates from N-Acylnitroso Diels-Alder Cycloadducts and 1-Amino-4-acetoxycyclopentenes

ChemInform, 2003-05, Vol.34 (20), p.no-no

2003

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Stereo‐ and Regioselectivity of Pd 0 /InI‐Mediated Allylic Additions to Aldehydes and Ketones. In situ Generation of Allylindium(III) Intermediates from N‐Acylnitroso Diels—Alder Cycloadducts and 1‐Amino‐4‐acetoxycyclopentenes

ChemInform, 2003-05, Vol.34 (20)

2003

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Experimental Neutron Capture Rate Constraint Far from Stability

Physical review letters, 2016-06, Vol.116 (24), p.242502-242502

2016

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Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors

From preclinical to clinical development: The example of a novel treatment for obesity

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors

Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1 H)ones as MCH-1 antagonists for the treatment of obesity

Synthesis and SAR of vinca alkaloid analogues

Stereo- and Regioselectivity of Pd0/InI-Mediated Allylic Additions to Aldehydes and Ketones. In Situ Generation of Allylindium(III) Intermediates from N-Acylnitroso Diels−Alder Cycloadducts and 1-Amino-4-acetoxycyclopentenes

Tetrahydrocarboline analogs as MCH-1 antagonists

Stereo- and regioselectivity of Pd(0)/InI-mediated allylic additions to aldehydes and ketones. In situ generation of allylindium(III) intermediates from N-acylnitroso Diels-Alder cycloadducts and 1-amino-4-acetoxycyclopentenes

Regio- and Stereoselective Ring Openings of 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene Systems with Copper Catalyst-Modified Grignard Reagents: Application to the Synthesis of an Inhibitor of 5-Lipoxygenase

Preparation of Sitagliptin M2 and M5 metabolites and degradation impurities through a stereocontrolled amidine reduction

Novel 1,4-Benzodiazepines from Acylnitroso-Derived Hetero-Diels−Alder Cycloadducts

Synthesis of a Conformationally Restricted Substrate Analogue of Siderophore Biosynthetases

Novel α-substituted β-amino diesters from acylnitroso-derived hetero-Diels–Alder cycloadducts

Regio- and Stereoselective Fe(III)- and Pd(0)-Mediated Ring Openings of 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene Systems

Regio- and Stereochemically Controlled Formation of Hydroxamic Acid Containing a nti- or s yn-1,4-Cycloalkenols from Acylnitroso-Derived Diels−Alder Adducts

Regio- and Stereochemically Controlled Formation of Hydroxamic Acid Containing anti- or syn-1,4-Cycloalkenols from Acylnitroso-Derived Diels−Alder Adducts

The synthesis and SAR of novel diarylsulfone 11b-HSD1 inhibitors

Stereo- and Regioselectivity of Pd 0 /InI-Mediated Allylic Additions to Aldehydes and Ketones. In Situ Generation of Allylindium(III) Intermediates from N -Acylnitroso Diels−Alder Cycloadducts and 1-Amino-4-acetoxycyclopentenes

ChemInform Abstract: Regio- and Stereochemically Controlled Formation of Hydroxamic Acid Containing anti- or syn-1,4-Cycloalkenols from Acylnitroso-Derived Diels-Alder Adducts

ChemInform Abstract: Novel 1,4-Benzodiazepines from Acylnitroso-Derived Hetero-Diels-Alder Cycloadducts

ChemInform Abstract: Novel α-Substituted β-Amino Diesters from Acylnitroso-Derived Hetero-Diels-Alder Cycloadducts

Stereo- and Regioselectivity of Pd0/InI-Mediated Allylic Additions to Aldehydes and Ketones. In situ Generation of Allylindium(III) Intermediates from N-Acylnitroso Diels-Alder Cycloadducts and 1-Amino-4-acetoxycyclopentenes

Stereo‐ and Regioselectivity of Pd 0 /InI‐Mediated Allylic Additions to Aldehydes and Ketones. In situ Generation of Allylindium(III) Intermediates from N‐Acylnitroso Diels—Alder Cycloadducts and 1‐Amino‐4‐acetoxycyclopentenes

Experimental Neutron Capture Rate Constraint Far from Stability

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