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Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns

mAbs, 2021-01, Vol.13 (1), p.1999195-1999195

2021

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Synthesis of LuxS Inhibitors Targeting Bacterial Cell−Cell Communication

Organic letters, 2004-09, Vol.6 (18), p.3043-3046

2004

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Analysis of Isoaspartic Acid by Selective Proteolysis with Asp-N and Electron Transfer Dissociation Mass Spectrometry

Analytical chemistry (Washington), 2010-09, Vol.82 (17), p.7485-7491

2010

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Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus

Autoimmunity (Chur, Switzerland), 2023-12, Vol.56 (1), p.2282945-2282945

2023

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Identifying Unknown Enzyme–Substrate Pairs from the Cellular Milieu with Native Mass Spectrometry

Chembiochem : a European journal of chemical biology, 2017-04, Vol.18 (7), p.613-617

2017

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Desulfurization of cysteine-containing peptides resulting from sample preparation for protein characterization by mass spectrometry

Rapid communications in mass spectrometry, 2010-02, Vol.24 (3), p.267-275

2010

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Substrate-Induced Control of Product Formation by Protein Arginine Methyltransferase 1

Biochemistry (Easton), 2013-01, Vol.52 (1), p.199-209

2013

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Comparison of Protein N-Homocysteinylation in Rat Plasma under Elevated Homocysteine Using a Specific Chemical Labeling Method

Molecules (Basel, Switzerland), 2016-09, Vol.21 (9), p.1195

2016

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Discovery and Characterization of a Photo-Oxidative Histidine-Histidine Cross-Link in IgG1 Antibody Utilizing 18O‑Labeling and Mass Spectrometry

Analytical chemistry (Washington), 2014-05, Vol.86 (10), p.4940-4948

2014

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Substrates of the Arabidopsis thaliana Protein Isoaspartyl Methyltransferase 1 Identified Using Phage Display and Biopanning

The Journal of biological chemistry, 2010-11, Vol.285 (48), p.37281-37292

2010

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Chemo-Enzymatic Detection of Protein Isoaspartate Using Protein Isoaspartate Methyltransferase and Hydrazine Trapping

Analytical chemistry (Washington), 2008-05, Vol.80 (10), p.3882-3889

2008

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Protein Isoaspartate Methyltransferase-Mediated 18O-Labeling of Isoaspartic Acid for Mass Spectrometry Analysis

Analytical chemistry (Washington), 2012-01, Vol.84 (2), p.1056-1062

2012

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Structure elucidation of highly polar basic degradants by on-line hydrogen/deuterium exchange hydrophilic interaction chromatography coupled to tandem mass spectrometry

Journal of Chromatography A, 2010-05, Vol.1217 (22), p.3598-3611

2010

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Synthetic strategies toward carbocyclic purine–pyrimidine hybrid nucleosides

Bioorganic & medicinal chemistry, 2009-08, Vol.17 (15), p.5520-5525

2009

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Mildly acidic conditions eliminate deamidation artifact during proteolysis: digestion with endoprotease Glu-C at pH 4.5

Amino acids, 2016-04, Vol.48 (4), p.1059-1067

2016

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Chemical synthesis of S-ribosyl- l-homocysteine and activity assay as a LuxS substrate

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3897-3900

2003

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Chemoenzymatic labeling of DNA methylation patterns for single-molecule epigenetic mapping

Nucleic acids research, 2022-09, Vol.50 (16), p.e92

2022

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Arginine Modifications by Methylglyoxal: Discovery in a Recombinant Monoclonal Antibody and Contribution to Acidic Species

Analytical chemistry (Washington), 2013-12, Vol.85 (23), p.11401-11409

2013

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Site-Specific Conjugation of Native Antibody: Transglutaminase-Mediated Modification of a Conserved Glutamine While Maintaining the Primary Sequence and Core Fc Glycan via Trimming with an Endoglycosidase

Bioconjugate chemistry, 2024-04, Vol.35 (4), p.465-471

2024

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A Mass Spectrometric Characterization of Light-Induced Modifications in Therapeutic Proteins

Journal of pharmaceutical sciences, 2022-06, Vol.111 (6), p.1556-1564

2022

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The emergence of AntibodyPlus: the future trend of antibody-based therapeutics

Antibody therapeutics, 2022-10, Vol.5 (4), p.280-287

2022

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Correction to Rapid Highly-Efficient Digestion and Peptide Mapping of Adeno-Associated Viruses

Analytical chemistry (Washington), 2021-12, Vol.93 (49), p.16734-16734

2021

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A stereospecific colorimetric assay for ( S, S)-adenosylmethionine quantification based on thiopurine methyltransferase-catalyzed thiol methylation

Analytical biochemistry, 2002-09, Vol.308 (2), p.358-363

2002

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Site‐specific Bioconjugation and Convergent Click Chemistry Enhances Antibody–Chromophore Conjugate Binding Efficiency

Photochemistry and photobiology, 2020-05, Vol.96 (3), p.596-603

2020

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Front Cover: Light‐Controllable Binary Switch Activation of CAR T Cells (ChemMedChem 12/2022)

ChemMedChem, 2022-06, Vol.17 (12), p.n/a

2022

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Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns

Synthesis of LuxS Inhibitors Targeting Bacterial Cell−Cell Communication

Analysis of Isoaspartic Acid by Selective Proteolysis with Asp-N and Electron Transfer Dissociation Mass Spectrometry

Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus

Identifying Unknown Enzyme–Substrate Pairs from the Cellular Milieu with Native Mass Spectrometry

Desulfurization of cysteine-containing peptides resulting from sample preparation for protein characterization by mass spectrometry

Substrate-Induced Control of Product Formation by Protein Arginine Methyltransferase 1

Comparison of Protein N-Homocysteinylation in Rat Plasma under Elevated Homocysteine Using a Specific Chemical Labeling Method

Discovery and Characterization of a Photo-Oxidative Histidine-Histidine Cross-Link in IgG1 Antibody Utilizing 18O‑Labeling and Mass Spectrometry

Substrates of the Arabidopsis thaliana Protein Isoaspartyl Methyltransferase 1 Identified Using Phage Display and Biopanning

Chemo-Enzymatic Detection of Protein Isoaspartate Using Protein Isoaspartate Methyltransferase and Hydrazine Trapping

Protein Isoaspartate Methyltransferase-Mediated 18O-Labeling of Isoaspartic Acid for Mass Spectrometry Analysis

Structure elucidation of highly polar basic degradants by on-line hydrogen/deuterium exchange hydrophilic interaction chromatography coupled to tandem mass spectrometry

Synthetic strategies toward carbocyclic purine–pyrimidine hybrid nucleosides

Mildly acidic conditions eliminate deamidation artifact during proteolysis: digestion with endoprotease Glu-C at pH 4.5

Chemical synthesis of S-ribosyl- l-homocysteine and activity assay as a LuxS substrate

Chemoenzymatic labeling of DNA methylation patterns for single-molecule epigenetic mapping

Arginine Modifications by Methylglyoxal: Discovery in a Recombinant Monoclonal Antibody and Contribution to Acidic Species

Site-Specific Conjugation of Native Antibody: Transglutaminase-Mediated Modification of a Conserved Glutamine While Maintaining the Primary Sequence and Core Fc Glycan via Trimming with an Endoglycosidase

A Mass Spectrometric Characterization of Light-Induced Modifications in Therapeutic Proteins

The emergence of AntibodyPlus: the future trend of antibody-based therapeutics

Correction to Rapid Highly-Efficient Digestion and Peptide Mapping of Adeno-Associated Viruses

A stereospecific colorimetric assay for ( S, S)-adenosylmethionine quantification based on thiopurine methyltransferase-catalyzed thiol methylation

Site‐specific Bioconjugation and Convergent Click Chemistry Enhances Antibody–Chromophore Conjugate Binding Efficiency

Front Cover: Light‐Controllable Binary Switch Activation of CAR T Cells (ChemMedChem 12/2022)

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