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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

ACS medicinal chemistry letters, 2010-04, Vol.1 (1), p.39-43

2010

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Identification of novel isoform-selective inhibitors within class I histone deacetylases

The Journal of pharmacology and experimental therapeutics, 2003-11, Vol.307 (2), p.720

2003

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Novel ATP-Competitive Kinesin Spindle Protein Inhibitors

Journal of medicinal chemistry, 2007-10, Vol.50 (20), p.4939-4952

2007

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Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor

The Journal of biological chemistry, 2000-05, Vol.275 (20), p.15254-15264

2000

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Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1694-1697

2009

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Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality

The Journal of biological chemistry, 2000-05, Vol.275 (21), p.16007-16014

2000

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Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.2015-2026

2001

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Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) α and β messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells

Cancer letters, 2002-12, Vol.188 (1), p.127-140

2002

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Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator

Journal of the American Chemical Society, 2008-06, Vol.130 (24), p.7584-7591

2008

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Corrigendum to “Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding” [Bioorg. Med. Chem. Lett. 19 (2009) 1694]

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2604-2604

2009

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Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR)

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.C62-C62

2009

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In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride

Cancer research (Chicago, Ill.), 1986-11, Vol.46 (11), p.5486-5493

1986

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Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils

Biochemical pharmacology, 1992-11, Vol.44 (10), p.2055-2066

1992

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Interactions of gold coordination complexes with DNA

Biochemical pharmacology, 1986-05, Vol.35 (9), p.1427-1433

1986

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Modulation of the antitumor and biochemical properties of bis(diphenylphosphine)ethane with metals

Cancer research (Chicago, Ill.), 1986-10, Vol.46 (10), p.5054-5060

1986

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Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models

Cancer research (Chicago, Ill.), 1985, Vol.45 (1), p.32-39

1985

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Characterization of CoA-independent transacylase activity in U937 cells

Biochimica et biophysica acta, 1991-02, Vol.1081 (3), p.339-346

1991

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Inhibitors of CoA-independent transacylase block the movement of arachidonate into 1-ether-linked phospholipids of human neutrophils

Biochemistry (Easton), 1995-04, Vol.34 (16), p.5403-5410

1995

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Beta-lactams SB 212047 and SB 216754 are irreversible, time-dependent inhibitors of coenzyme A-independent transacylase

Molecular pharmacology, 1998-02, Vol.53 (2), p.322-329

1998

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Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes

Journal of medicinal chemistry, 1986-02, Vol.29 (2), p.218-223

1986

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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295

ACS medicinal chemistry letters, 2010-04, Vol.1 (1), p.30-34

2010

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In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane

Molecular pharmacology, 1991-01, Vol.39 (1), p.90-97

1991

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Abstract C63: Biological characterization of GSK2126458, a novel and potent inhibitor of phosphoinositide 3-kinase and the mammalian target of rapamycin (mTOR)

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.C63-C63

2009

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Inter-strand cross-links and single-strand breaks produced by gold(I) and gold(III) coordination complexes

Biochemical pharmacology, 1986-05, Vol.35 (9), p.1435-1443

1986

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A murine model to evaluate the ability of in vitro clonogenic assays to predict the response to tumors in vivo

Cancer research (Chicago, Ill.), 1988-10, Vol.48 (19), p.5447-5454

1988

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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Identification of novel isoform-selective inhibitors within class I histone deacetylases

Novel ATP-Competitive Kinesin Spindle Protein Inhibitors

Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor

Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7

Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) α and β messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells

Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator

Corrigendum to “Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding” [Bioorg. Med. Chem. Lett. 19 (2009) 1694]

Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR)

In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride

Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils

Interactions of gold coordination complexes with DNA

Modulation of the antitumor and biochemical properties of bis(diphenylphosphine)ethane with metals

Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models

Characterization of CoA-independent transacylase activity in U937 cells

Inhibitors of CoA-independent transacylase block the movement of arachidonate into 1-ether-linked phospholipids of human neutrophils

Beta-lactams SB 212047 and SB 216754 are irreversible, time-dependent inhibitors of coenzyme A-independent transacylase

Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295

In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane

Abstract C63: Biological characterization of GSK2126458, a novel and potent inhibitor of phosphoinositide 3-kinase and the mammalian target of rapamycin (mTOR)

Inter-strand cross-links and single-strand breaks produced by gold(I) and gold(III) coordination complexes

A murine model to evaluate the ability of in vitro clonogenic assays to predict the response to tumors in vivo

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