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The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.2863-2874

2009

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Identification and Characterization of Nucleolin as a c-myc G-quadruplex-binding Protein

The Journal of biological chemistry, 2009-08, Vol.284 (35), p.23622-23635

2009

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Selective Antitumor Activity of Datelliptium toward Medullary Thyroid Carcinoma by Downregulating RET Transcriptional Activity

Cancers, 2021-06, Vol.13 (13), p.3288

2021

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Biochemical techniques for the characterization of G-quadruplex structures: EMSA, DMS footprinting, and DNA polymerase stop assay

Methods in molecular biology (Clifton, N.J.), 2010-01, Vol.608, p.65

2010

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Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter

Journal of the American Chemical Society, 2006-04, Vol.128 (16), p.5404-5415

2006

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Formation of Pseudosymmetrical G-Quadruplex and i-Motif Structures in the Proximal Promoter Region of the RET Oncogene

Journal of the American Chemical Society, 2007-08, Vol.129 (33), p.10220-10228

2007

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Characterization of DNA Damage Induced by a Natural Product Antitumor Antibiotic Leinamycin in Human Cancer Cells

Chemical research in toxicology, 2010-01, Vol.23 (1), p.99-107

2010

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Chromatin Immunoprecipitation Assay to Analyze the Effect of G-Quadruplex Interactive Agents on the Binding of RNA Polymerase II and Transcription Factors to a Target Promoter Region

Methods in molecular biology (Clifton, N.J.), 2019-01, Vol.2035, p.233

Sun, Daekyu

2019

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Synthesis of alamandine glycoside analogs as new drug candidates to antagonize the MrgD receptor for pain relief

Medicinal chemistry research, 2022-07, Vol.31 (7), p.1135-1146

2022

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The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex–interactive agents

Molecular cancer therapeutics, 2008-04, Vol.7 (4), p.880-889

2008

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Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes

Cancers, 2023-04, Vol.15 (7), p.2163

2023

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NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1

Molecular cancer therapeutics, 2009-05, Vol.8 (5), p.1363-1377

2009

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Quadruplex-Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase

Journal of medicinal chemistry, 2001-12, Vol.44 (26), p.4509-4523

2001

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Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative

International journal of oncology, 2017-07, Vol.51 (1), p.145-157

2017

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Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma (MTC)

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Abstract 5546: A natural alkaloid, berberine, as a novel transcriptional repressor of RET proto-oncogene in medullary thyroid carcinoma

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5546-5546

2015

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A novel cell‐based Screening System Identifies Adefovir‐dipivoxil as Suppressor of RET expression in medullary thyroid carcinoma

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Journal of medicinal chemistry, 1997-07, Vol.40 (14), p.2113-2116

1997

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Abstract 4783: Selective antitumor activity of NSC311152 toward medullary thyroid cancer by downregulating the transcription of RET oncogene

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4783-4783

2018

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Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes

Methods in molecular biology (Clifton, N.J.), 2019-01, Vol.2035, p.201

2019

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Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma

International journal of oncology, 2020-01, Vol.56 (1), p.348-358

2020

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Heterogeneous Nuclear Ribonucleoprotein K and Nucleolin as Transcriptional Activators of the Vascular Endothelial Growth Factor Promoter through Interaction with Secondary DNA Structures

Biochemistry (Easton), 2011-05, Vol.50 (18), p.3796-3806

2011

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Abstract 745: Role of G-quadruplex structures in the human RET promoter region in the regulation of this gene

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.745-745

2013

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Effect of DNA Secondary Structure on Human Telomerase Activity

Biochemistry (Easton), 1998-04, Vol.37 (16), p.5536-5541

1998

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Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene

Nucleic acids research, 2011-03, Vol.39 (4), p.1256

2011

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The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

Identification and Characterization of Nucleolin as a c-myc G-quadruplex-binding Protein

Selective Antitumor Activity of Datelliptium toward Medullary Thyroid Carcinoma by Downregulating RET Transcriptional Activity

Biochemical techniques for the characterization of G-quadruplex structures: EMSA, DMS footprinting, and DNA polymerase stop assay

Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter

Formation of Pseudosymmetrical G-Quadruplex and i-Motif Structures in the Proximal Promoter Region of the RET Oncogene

Characterization of DNA Damage Induced by a Natural Product Antitumor Antibiotic Leinamycin in Human Cancer Cells

Chromatin Immunoprecipitation Assay to Analyze the Effect of G-Quadruplex Interactive Agents on the Binding of RNA Polymerase II and Transcription Factors to a Target Promoter Region

Synthesis of alamandine glycoside analogs as new drug candidates to antagonize the MrgD receptor for pain relief

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex–interactive agents

Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1

Quadruplex-Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase

Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative

Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma (MTC)

Abstract 5546: A natural alkaloid, berberine, as a novel transcriptional repressor of RET proto-oncogene in medullary thyroid carcinoma

A novel cell‐based Screening System Identifies Adefovir‐dipivoxil as Suppressor of RET expression in medullary thyroid carcinoma

Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

Abstract 4783: Selective antitumor activity of NSC311152 toward medullary thyroid cancer by downregulating the transcription of RET oncogene

Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes

Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma

Heterogeneous Nuclear Ribonucleoprotein K and Nucleolin as Transcriptional Activators of the Vascular Endothelial Growth Factor Promoter through Interaction with Secondary DNA Structures

Abstract 745: Role of G-quadruplex structures in the human RET promoter region in the regulation of this gene

Effect of DNA Secondary Structure on Human Telomerase Activity

Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene

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