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Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation

Journal of virology, 2018-05, Vol.92 (10)

2018

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Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2

PLoS pathogens, 2016-12, Vol.12 (12), p.e1005955-e1005955

2016

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HIV-1 with gag processing defects activates cGAS sensing

Retrovirology, 2024-05, Vol.21 (1), p.10-15, Article 10

2024

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Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7

PLoS pathogens, 2011-09, Vol.7 (9), p.e1002247-e1002247

2011

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DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing

Cell reports (Cambridge), 2018-11, Vol.25 (7), p.1953-1965.e4

2018

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HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

eLife, 2020-12, Vol.9

2020

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HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65

Retrovirology, 2022-01, Vol.19 (1), p.2-14, Article 2

2022

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Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

PLoS pathogens, 2013-02, Vol.9 (2), p.e1003183

2013

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Vaccinia Virus Inhibits NF-κB-Dependent Gene Expression Downstream of p65 Translocation

Journal of Virology, 2014-03, Vol.88 (6), p.3092-3102

2014

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Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

Frontiers in immunology, 2017-10, Vol.8, p.1246-1246

2017

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The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways

Journal of Immunology Research, 2022-07, Vol.2022, p.1-13

2022

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Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity

Molecular therapy. Methods & clinical development, 2020-06, Vol.17, p.209-219

2020

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Disrupting HIV‐1 capsid formation causes cGAS sensing of viral DNA

The EMBO journal, 2020-10, Vol.39 (20), p.e103958-n/a

2020

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Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity

Journal of general virology, 2013-11, Vol.94 (Pt 11), p.2367-2392

2013

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KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control

EMBO reports, 2018-10, Vol.19 (10), p.n/a

2018

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Poxin-deficient poxviruses are sensed by cGAS prior to genome replication

Journal of general virology, 2024-10, Vol.105 (10)

2024

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Engineered Promoter-Switched Viruses Reveal the Role of Poxvirus Maturation Protein A26 as a Negative Regulator of Viral Spread

Journal of virology, 2021-09, Vol.95 (19), p.e0101221-e0101221

2021

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Disruption of the cGAS/STING axis does not impair sensing of MVA in BHK21 cells

Journal of general virology, 2022-05, Vol.103 (5)

2022

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Distinct monkeypox virus lineages co-circulating in humans before 2022

Nature medicine, 2023-09, Vol.29 (9), p.2317-2324

2023

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Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators

Vaccine, 2016-09, Vol.34 (40), p.4827-4834

2016

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Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacy

Journal of general virology, 2013-05, Vol.94 (Pt 5), p.1121-1126

2013

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Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence

Journal of general virology, 2013-09, Vol.94 (Pt 9), p.2070-2081

2013

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Evasion of cGAS and TRIM5 defines pandemic HIV

Nature microbiology, 2022-11, Vol.7 (11), p.1762-1776

2022

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Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection

Journal of general virology, 2014-12, Vol.95 (Pt 12), p.2757-2768

2014

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Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues

Journal of general virology, 2014-09, Vol.95 (Pt 9), p.2038-2049

2014

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Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation

Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2

HIV-1 with gag processing defects activates cGAS sensing

Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7

DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65

Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence

Vaccinia Virus Inhibits NF-κB-Dependent Gene Expression Downstream of p65 Translocation

Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways

Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity

Disrupting HIV‐1 capsid formation causes cGAS sensing of viral DNA

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity

KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control

Poxin-deficient poxviruses are sensed by cGAS prior to genome replication

Engineered Promoter-Switched Viruses Reveal the Role of Poxvirus Maturation Protein A26 as a Negative Regulator of Viral Spread

Disruption of the cGAS/STING axis does not impair sensing of MVA in BHK21 cells

Distinct monkeypox virus lineages co-circulating in humans before 2022

Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators

Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacy

Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence

Evasion of cGAS and TRIM5 defines pandemic HIV

Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection

Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues

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