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Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

The Journal of pharmacology and experimental therapeutics, 2007-07, Vol.322 (1), p.205-213

2007

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Combining PET Biodistribution and Equilibrium Dialysis Assays to Assess the Free Brain Concentration and BBB Transport of CNS Drugs

Journal of cerebral blood flow and metabolism, 2012-05, Vol.32 (5), p.874-883

2012

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Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain

The Journal of pharmacology and experimental therapeutics, 2006-03, Vol.316 (3), p.1282-1290

2006

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Examining the Uptake of Central Nervous System Drugs and Candidates across the Blood-Brain Barrier

The Journal of pharmacology and experimental therapeutics, 2016-08, Vol.358 (2), p.294-305

2016

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Free Drug Theory – No Longer Just a Hypothesis?

Pharmaceutical research, 2022-02, Vol.39 (2), p.213-222

2022

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Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems

Drug discovery today, 2018-07, Vol.23 (7), p.1357-1372

2018

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Influence of Secondary Structure on the Fragmentation of Protonated Peptides

Journal of the American Chemical Society, 1999-06, Vol.121 (22), p.5142-5154

1999

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Perspectives on gender parity in bioanalysis: an interview with Scott Summerfield

Bioanalysis, 2019-04, Vol.11 (7), p.675-676

Summerfield, Scott G

2019

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The GSK Bioanalytical Hub model in bioanalysis: maximizing the synergies of co-locating various platforms in support of regulated and nonregulated study end points

Bioanalysis, 2023-02, Vol.15 (3), p.127-132

2023

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Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System

Molecular pharmaceutics, 2016-05, Vol.13 (5), p.1540-1550

2016

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Drug Distribution into Peripheral Nerve

The Journal of pharmacology and experimental therapeutics, 2018-05, Vol.365 (2), p.336-345

2018

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Incurred sample reanalysis at GSK: what have we learned?

Bioanalysis, 2018-11, Vol.10 (21), p.1755-1766

2018

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The importance of evaluating the chemical structures and strategies to avoid pitfalls in quantitative bioanalysis

Bioanalysis, 2019-01, Vol.11 (2), p.85-101

2019

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Toward best practices in data processing and analysis for intact biotherapeutics by MS in quantitative bioanalysis

Bioanalysis, 2017-12, Vol.9 (23), p.1883-1893

2017

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The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization

The Journal of pharmacology and experimental therapeutics, 2005-03, Vol.312 (3), p.1161-1169

2005

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In vitro, in vivo and in silico models of drug distribution into the brain

Journal of pharmacokinetics and pharmacodynamics, 2013-06, Vol.40 (3), p.301-314

2013

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Investigation into the role of P2X 3 /P2X 2/3 receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study

British journal of pharmacology, 2009-01, Vol.148 (6), p.845-852

2009

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Rapid bioavailability and disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state tissue disstribution using fewer animals

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S69-S69

2017

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Integrating internal and external bioanalytical support to deliver a diversified pharmaceutical portfolio

Bioanalysis, 2014-05, Vol.6 (10), p.1311-1319

2014

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Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study

British journal of pharmacology, 2006-07, Vol.148 (6), p.845-852

2006

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In vitro prediction of brain penetration - a case for free thinking?

Expert opinion on drug discovery, 2006-11, Vol.1 (6), p.595-607

2006

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Fragmentation efficiencies of peptide ions following low energy collisional activation

International journal of mass spectrometry and ion processes, 1997-11, Vol.165, p.509-521

1997

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The promotion of d-type ions during the low energy collision-induced dissociation of some cysteic acid-containing peptides

Journal of the American Society for Mass Spectrometry, 1997, Vol.8 (1), p.25-31

1997

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Phenyl thiocarbamoyl and related derivatives of peptides: Edman chemistry in the gas phase

International journal of mass spectrometry, 1999, Vol.188 (1), p.95-103

1999

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Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

Combining PET Biodistribution and Equilibrium Dialysis Assays to Assess the Free Brain Concentration and BBB Transport of CNS Drugs

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain

Examining the Uptake of Central Nervous System Drugs and Candidates across the Blood-Brain Barrier

Free Drug Theory – No Longer Just a Hypothesis?

Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems

Influence of Secondary Structure on the Fragmentation of Protonated Peptides

Perspectives on gender parity in bioanalysis: an interview with Scott Summerfield

The GSK Bioanalytical Hub model in bioanalysis: maximizing the synergies of co-locating various platforms in support of regulated and nonregulated study end points

Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System

Drug Distribution into Peripheral Nerve

Incurred sample reanalysis at GSK: what have we learned?

The importance of evaluating the chemical structures and strategies to avoid pitfalls in quantitative bioanalysis

Toward best practices in data processing and analysis for intact biotherapeutics by MS in quantitative bioanalysis

In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders

The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization

In vitro, in vivo and in silico models of drug distribution into the brain

Investigation into the role of P2X 3 /P2X 2/3 receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study

Rapid bioavailability and disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state tissue disstribution using fewer animals

Integrating internal and external bioanalytical support to deliver a diversified pharmaceutical portfolio

Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study

In vitro prediction of brain penetration - a case for free thinking?

Fragmentation efficiencies of peptide ions following low energy collisional activation

The promotion of d-type ions during the low energy collision-induced dissociation of some cysteic acid-containing peptides

Phenyl thiocarbamoyl and related derivatives of peptides: Edman chemistry in the gas phase

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