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Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

PLoS pathogens, 2021-11, Vol.17 (11), p.e1010069-e1010069

2021

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Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.12200-12227

2021

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Mechanistic Exploration of the Palladium-catalyzed Process for the Synthesis of Benzoxazoles and Benzothiazoles

Journal of organic chemistry, 2013-02, Vol.78 (4), p.1471-1477

2013

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A Powerful Palladium-Catalyzed Multicomponent Process for the Preparation of Oxazolines and Benzoxazoles

Organic letters, 2011-12, Vol.13 (23), p.6256-6259

2011

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The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing

Frontiers in immunology, 2022-08, Vol.13, p.953053

2022

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Protection against lung pathology during obesity-accelerated ageing in mice by the parasitic worm product ES-62

Frontiers in immunology, 2023, Vol.14, p.1285069-1285069

2023

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Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis

Frontiers in immunology, 2018-05, Vol.9, p.1016-1016

2018

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Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification

International journal of molecular sciences, 2022-10, Vol.23 (19), p.11912

2022

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The allure of targets for novel drugs

RSC medicinal chemistry, 2024-02, Vol.15 (2), p.472-484

Suckling, Colin J

2024

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Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase

Biochemistry (Easton), 2014-07, Vol.53 (25), p.4216-4223

2014

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Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease

Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2669

2018

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Antimicrobial Lexitropsins Containing Amide, Amidine, and Alkene Linking Groups

Journal of medicinal chemistry, 2007-11, Vol.50 (24), p.6116-6125

2007

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Minor groove binders as anti-infective agents

Pharmacology & therapeutics (Oxford), 2013-07, Vol.139 (1), p.12-23

2013

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Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model

Molecular and biochemical parasitology, 2019-12, Vol.234, p.111232-111232, Article 111232

2019

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Mycobacterium tuberculosis Decaprenylphosphoryl-β‑d‑ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2557-2576

2020

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Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.695-709

2017

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Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders

Acta crystallographica. Section E, Crystallographic communications, 2017-02, Vol.73 (Pt 2), p.254-259

2017

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Enzyme chemistry: impact and applications

Suckling, C. J. (Colin J.)

Second Edition., 1990

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Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.9982-10002

2013

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The diversity‐oriented synthesis of pteridines—achievements and potential for development

IUBMB life, 2013-04, Vol.65 (4), p.283-299

Suckling, Colin J.

2013

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Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model

Journal of medicinal chemistry, 2019-03, Vol.62 (6), p.3021-3035

2019

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Intranasally administered S-MGB-364 displays antitubercular activity and modulates the host immune response to Mycobacterium tuberculosis infection

Journal of antimicrobial chemotherapy, 2022-03, Vol.77 (4), p.1061-1071

2022

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Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Journal of autoimmunity, 2015-06, Vol.60, p.59-73

2015

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Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1370-1387

2016

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Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Scientific reports, 2018-02, Vol.8 (1), p.2123-11, Article 2123

2018

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Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression

Mechanistic Exploration of the Palladium-catalyzed Process for the Synthesis of Benzoxazoles and Benzothiazoles

A Powerful Palladium-Catalyzed Multicomponent Process for the Preparation of Oxazolines and Benzoxazoles

The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing

Protection against lung pathology during obesity-accelerated ageing in mice by the parasitic worm product ES-62

Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis

Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification

The allure of targets for novel drugs

Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase

Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease

Antimicrobial Lexitropsins Containing Amide, Amidine, and Alkene Linking Groups

Minor groove binders as anti-infective agents

Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model

Mycobacterium tuberculosis Decaprenylphosphoryl-β‑d‑ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders

Enzyme chemistry: impact and applications

Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis

The diversity‐oriented synthesis of pteridines—achievements and potential for development

Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model

Intranasally administered S-MGB-364 displays antitubercular activity and modulates the host immune response to Mycobacterium tuberculosis infection

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives

Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

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