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Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer

Frontiers in immunology, 2018-08, Vol.9, p.1613-1613

2018

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Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression

PloS one, 2015-06, Vol.10 (6), p.e0130490-e0130490

2015

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A monovalent anti-human CD28 domain antibody antagonist: preclinical efficacy and safety

The Journal of immunology (1950), 2013-11, Vol.191 (9), p.4599-4610

2013

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Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation

Transplantation, 2009-03, Vol.87 (6), p.926

2009

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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope

Journal of molecular biology, 2016-07, Vol.428 (14), p.2860-2879

2016

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Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity

Journal of rheumatology, 2007-11, Vol.34 (11), p.2204

2007

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Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases

The Journal of immunology (1950), 2014-05, Vol.192 (9), p.4083-4092

2014

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Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699

The Journal of pharmacology and experimental therapeutics, 2015-12, Vol.355 (3), p.506

2015

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Potent and Selective Agonists of Sphingosine 1‑Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2820-2840

2016

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Pellet digestion: a simple and efficient sample preparation technique for LC-MS/MS quantification of large therapeutic proteins in plasma

Bioanalysis, 2012-01, Vol.4 (1), p.17-28

2012

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Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction

Clinical immunology (Orlando, Fla.), 2008-01, Vol.126 (1), p.38-47

2008

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B cells from African American lupus patients exhibit an activated phenotype

JCI insight, 2016-06, Vol.1 (9), p.e87310-e87310

2016

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An LFA-1 ({alpha}L{beta}2) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in Murine Models of Arthritis

The Journal of immunology (1950), 2010-04, Vol.184 (7), p.3917-3926

2010

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Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1)

Bioorganic & medicinal chemistry letters, 2016-05, Vol.26 (10), p.2470-2474

2016

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Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Journal of medicinal chemistry, 2010-05, Vol.53 (9), p.3814-3830

2010

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Abatacept Does Not Induce Direct Gene Expression Changes in Antigen-Presenting Cells

Journal of clinical immunology, 2009-07, Vol.29 (4), p.479-489

2009

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Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101)A Small Molecule Antagonist of Leukocyte Function Associated Antigen-1

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.6946-6949

2006

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Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils

The Journal of immunology (1950), 1998-05, Vol.160 (10), p.5154-5162

1998

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Potent Reversible Inhibitors of the Protein Tyrosine Phosphatase CD45

Journal of medicinal chemistry, 2001-05, Vol.44 (11), p.1777-1793

2001

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Antibody Drug-Target Engagement Measurement in Tissue Using Quantitative Affinity Extraction Liquid Chromatography–Mass Spectrometry: Method Development and Qualification

Analytical chemistry (Washington), 2017-05, Vol.89 (9), p.5115-5123

2017

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Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1908-1911

2007

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De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.1161-1164

2005

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Generation and characterization of a mouse LIGHT specific inhibitor in a murine model of colitis (THER4P.891)

The Journal of immunology (1950), 2014-05, Vol.192 (1_Supplement), p.137-137.3

2014

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Co-stimulatory molecules as therapeutic targets in allergic airways disease

Drug discovery today. Therapeutic strategies, 2007, Vol.4 (1), p.39-47

2007

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Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Non-Human Primate Renal Allograft Rejection

American journal of transplantation, 2017-02, Vol.17 (5), p.1182-1192

2017

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Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer

Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression

A monovalent anti-human CD28 domain antibody antagonist: preclinical efficacy and safety

Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation

Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope

Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity

Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases

Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699

Potent and Selective Agonists of Sphingosine 1‑Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series

Pellet digestion: a simple and efficient sample preparation technique for LC-MS/MS quantification of large therapeutic proteins in plasma

Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction

B cells from African American lupus patients exhibit an activated phenotype

An LFA-1 ({alpha}L{beta}2) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in Murine Models of Arthritis

Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1)

Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Abatacept Does Not Induce Direct Gene Expression Changes in Antigen-Presenting Cells

Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101)A Small Molecule Antagonist of Leukocyte Function Associated Antigen-1

Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils

Potent Reversible Inhibitors of the Protein Tyrosine Phosphatase CD45

Antibody Drug-Target Engagement Measurement in Tissue Using Quantitative Affinity Extraction Liquid Chromatography–Mass Spectrometry: Method Development and Qualification

Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold

De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold

Generation and characterization of a mouse LIGHT specific inhibitor in a murine model of colitis (THER4P.891)

Co-stimulatory molecules as therapeutic targets in allergic airways disease

Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Non-Human Primate Renal Allograft Rejection

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