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Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure

Pharmacological reviews, 2019-10, Vol.71 (4), p.539-570

2019

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ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

Clinical science (1979), 2020-11, Vol.134 (21), p.2851-2871

2020

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Advances in the structural basis for angiotensin-1 converting enzyme (ACE) inhibitors

Bioscience reports, 2024-08, Vol.44 (8)

2024

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Proteomic Analysis of Human Macrophages Overexpressing Angiotensin-Converting Enzyme

International journal of molecular sciences, 2024-07, Vol.25 (13), p.7055

2024

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Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C‑Domain: Implications for Drug Design

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10141-10154

2018

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Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

Nature (London), 2003-01, Vol.421 (6922), p.551-554

2003

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Structural Details on the Binding of Antihypertensive Drugs Captopril and Enalaprilat to Human Testicular Angiotensin I-Converting Enzyme

Biochemistry (Easton), 2004-07, Vol.43 (27), p.8718-8724

2004

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Crystal Structure of the N Domain of Human Somatic Angiotensin I-converting Enzyme Provides a Structural Basis for Domain-specific Inhibitor Design

Journal of molecular biology, 2006-03, Vol.357 (3), p.964-974

2006

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Ace revisited: A new target for structure-based drug design

Nature reviews. Drug discovery, 2003-11, Vol.2 (11), p.891-902

2003

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Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors

Clinical science (1979), 2014-02, Vol.126 (4), p.305-313

2014

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Established and novel pathophysiological mechanisms of pericardial injury and constrictive pericarditis

World journal of cardiology, 2018-09, Vol.10 (9), p.87-96

2018

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Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension

Clinical science (1979), 2014-07, Vol.127 (1), p.57-63

2014

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Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE)

The Journal of biological chemistry, 2014-01, Vol.289 (3), p.1798-1814

2014

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Exploring the Impact of ACE Inhibition in Immunity and Disease

Journal of the Renin-Angiotensin-Aldosterone System, 2022-01, Vol.2022, p.9028969-9028969

2022

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Investigating the Domain Specificity of Phosphinic Inhibitors RXPA380 and RXP407 in Angiotensin-Converting Enzyme

Biochemistry (Easton), 2009-09, Vol.48 (35), p.8405-8412

2009

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An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding

PloS one, 2011-10, Vol.6 (10), p.e25952

2011

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Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics

The FEBS journal, 2021-04, Vol.288 (7), p.2238-2256

2021

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Cryo‐EM reveals mechanisms of angiotensin I‐converting enzyme allostery and dimerization

The EMBO journal, 2022-08, Vol.41 (16), p.e110550-n/a

2022

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Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa

Nature reviews. Microbiology, 2020-12, Vol.18 (12), p.690-704

2020

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Angiotensin-Converting Enzyme-2 (ACE2): Comparative Modeling of the Active Site, Specificity Requirements, and Chloride Dependence

Biochemistry (Easton), 2003-11, Vol.42 (45), p.13185-13192

2003

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Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide

Biochemical journal, 2011-05, Vol.436 (1), p.53-59

2011

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A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP

PloS one, 2014-02, Vol.9 (2), p.e88001-e88001

2014

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Molecular Basis for Omapatrilat and Sampatrilat Binding to NeprilysinImplications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5488-5500

2020

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ACE-domain selectivity extends beyond direct interacting residues at the active site

Biochemical journal, 2020-04, Vol.477 (7), p.1241-1259

2020

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Crystal Structure of Protoporphyrinogen Oxidase from Myxococcus xanthus and Its Complex with the Inhibitor Acifluorfen

The Journal of biological chemistry, 2006-12, Vol.281 (50), p.38625-38633

2006

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Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure

ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

Advances in the structural basis for angiotensin-1 converting enzyme (ACE) inhibitors

Proteomic Analysis of Human Macrophages Overexpressing Angiotensin-Converting Enzyme

Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C‑Domain: Implications for Drug Design

Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

Structural Details on the Binding of Antihypertensive Drugs Captopril and Enalaprilat to Human Testicular Angiotensin I-Converting Enzyme

Crystal Structure of the N Domain of Human Somatic Angiotensin I-converting Enzyme Provides a Structural Basis for Domain-specific Inhibitor Design

Ace revisited: A new target for structure-based drug design

Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors

Established and novel pathophysiological mechanisms of pericardial injury and constrictive pericarditis

Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension

Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE)

Exploring the Impact of ACE Inhibition in Immunity and Disease

Investigating the Domain Specificity of Phosphinic Inhibitors RXPA380 and RXP407 in Angiotensin-Converting Enzyme

An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding

Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics

Cryo‐EM reveals mechanisms of angiotensin I‐converting enzyme allostery and dimerization

Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa

Angiotensin-Converting Enzyme-2 (ACE2): Comparative Modeling of the Active Site, Specificity Requirements, and Chloride Dependence

Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide

A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP

Molecular Basis for Omapatrilat and Sampatrilat Binding to NeprilysinImplications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

ACE-domain selectivity extends beyond direct interacting residues at the active site

Crystal Structure of Protoporphyrinogen Oxidase from Myxococcus xanthus and Its Complex with the Inhibitor Acifluorfen

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