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Caspase-8 as a therapeutic target in cancer

Cancer letters, 2013-05, Vol.332 (2), p.133-140

Stupack, Dwayne G

2013

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Targeting FAK in anticancer combination therapies

Nature reviews. Cancer, 2021-05, Vol.21 (5), p.313-324

2021

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Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

PLoS genetics, 2020-01, Vol.16 (1), p.e1008558

2020

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Get a ligand, get a life: integrins, signaling and cell survival

Journal of cell science, 2002-10, Vol.115 (Pt 19), p.3729-3738

2002

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Underlying Subwavelength Aperture Architecture Drives the Optical Properties of Microcavity Surface Plasmon Resonance Sensors

Sensors (Basel, Switzerland), 2020-08, Vol.20 (17), p.4906

2020

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Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas

PloS one, 2016-07, Vol.11 (7), p.e0159114

2016

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PFKFB4 Promotes Breast Cancer Metastasis via Induction of Hyaluronan Production in a p38-Dependent Manner

Cellular physiology and biochemistry, 2018-01, Vol.50 (6), p.2108-2123

2018

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FERM control of FAK function: Implications for cancer therapy

Cell cycle (Georgetown, Tex.), 2008-08, Vol.7 (15), p.2306-2314

2008

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Nonsense-mediated RNA decay: an emerging modulator of malignancy

Nature reviews. Cancer, 2022-08, Vol.22 (8), p.437-451

2022

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Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor

Journal of Virology, 2007-10, Vol.81 (19), p.10249-10257

2007

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Role of Raf in Vascular Protection from Distinct Apoptotic Stimuli

Science (American Association for the Advancement of Science), 2003-07, Vol.301 (5629), p.94-96

2003

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Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

Clinical & experimental metastasis, 2013-06, Vol.30 (5), p.579-594

2013

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Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer

Nature communications, 2017-02, Vol.8 (1), p.14423-14423, Article 14423

2017

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PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

Cancer biology & therapy, 2010-05, Vol.9 (10), p.764-777

2010

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Potentiation of neuroblastoma metastasis by loss of caspase-8

Nature, 2006-01, Vol.439 (7072), p.95-99

2006

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Rab5 mediates caspase-8-promoted cell motility and metastasis

Molecular biology of the cell, 2010-01, Vol.21 (2), p.369-376

2010

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Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

Cancer biology & therapy, 2010-05, Vol.9 (10), p.778-790

2010

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Apoptosis of Adherent Cells by Recruitment of Caspase-8 to Unligated Integrins

The Journal of cell biology, 2001-10, Vol.155 (3), p.459-470

2001

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Focal adhesion kinase signaling - tumor vulnerabilities and clinical opportunities

Journal of cell science, 2024-07, Vol.137 (14)

2024

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Fra-1 Promotes Breast Cancer Chemosensitivity by Driving Cancer Stem Cells from Dormancy

Cancer research (Chicago, Ill.), 2012-07, Vol.72 (14), p.3451-3456

2012

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marine lipopeptide somocystinamide A triggers apoptosis via caspase 8

Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (7), p.2313-2318

2008

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Rab5 in the regulation of cell motility and invasion

Current protein & peptide science, 2011-02, Vol.12 (1), p.43-51

2011

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EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1

PloS one, 2012-05, Vol.7 (5), p.e36753-e36753

2012

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CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism

Theranostics, 2018-01, Vol.8 (22), p.6248-6262

2018

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Retraction for Nasimuzzaman et al., “Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor”

Journal of virology, 2020-09, Vol.94 (19)

2020

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Caspase-8 as a therapeutic target in cancer

Targeting FAK in anticancer combination therapies

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

Get a ligand, get a life: integrins, signaling and cell survival

Underlying Subwavelength Aperture Architecture Drives the Optical Properties of Microcavity Surface Plasmon Resonance Sensors

Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas

PFKFB4 Promotes Breast Cancer Metastasis via Induction of Hyaluronan Production in a p38-Dependent Manner

FERM control of FAK function: Implications for cancer therapy

Nonsense-mediated RNA decay: an emerging modulator of malignancy

Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor

Role of Raf in Vascular Protection from Distinct Apoptotic Stimuli

Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

Potentiation of neuroblastoma metastasis by loss of caspase-8

Rab5 mediates caspase-8-promoted cell motility and metastasis

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

Apoptosis of Adherent Cells by Recruitment of Caspase-8 to Unligated Integrins

Focal adhesion kinase signaling - tumor vulnerabilities and clinical opportunities

Fra-1 Promotes Breast Cancer Chemosensitivity by Driving Cancer Stem Cells from Dormancy

marine lipopeptide somocystinamide A triggers apoptosis via caspase 8

Rab5 in the regulation of cell motility and invasion

EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1

CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism

Retraction for Nasimuzzaman et al., “Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor”

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