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Data on the design and operation of drones by both individuals and teams

Data in brief, 2021-06, Vol.36, p.107008-107008, Article 107008

2021

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Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.6954-6957

2006

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Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.1062-1069

2017

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Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis

The Journal of pharmacology and experimental therapeutics, 2009-02, Vol.328 (2), p.571

2009

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Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.107-114

2016

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In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide

The Journal of pharmacology and experimental therapeutics, 2005-12, Vol.315 (3), p.1362

2005

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Block of Peripheral Nerve Sodium Channels Selectively Inhibits Features of Neuropathic Pain in Rats

Molecular pharmacology, 2006-03, Vol.69 (3), p.823-832

2006

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Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure

The Journal of pharmacology and experimental therapeutics, 2008-01, Vol.324 (1), p.322

2008

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Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.807-819

2007

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Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3997-4000

2007

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The Prototype Serotonin 5-HT1B/1D Agonist Sumatriptan Increases the Severity of Myocardial Ischemia During Atrial Pacing in Dogs With Coronary Artery Stenosis

Journal of cardiovascular pharmacology, 2009-06, Vol.53 (6), p.474-479

2009

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NR2B-Selective N-Methyl-d-aspartate Antagonists: Synthesis and Evaluation of 5-Substituted Benzimidazoles

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.2089-2096

2004

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Orally Efficacious NR2B-Selective NMDA Receptor Antagonists

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.697-700

2003

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In Vivo Cardiac Electrophysiologic and Antiarrhythmic Effects of an Isoquinoline IKur Blocker, ISQ-1, in Rat, Dog, and Nonhuman Primate

Journal of cardiovascular pharmacology, 2007-04, Vol.49 (4), p.236-245

2007

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Decoding the agility of artificial intelligence-assisted human design teams

Design studies, 2022-03, Vol.79, p.101094, Article 101094

2022

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Benzodiazepines as Potent and Selective Bradykinin B1 Antagonists

Journal of medicinal chemistry, 2003-05, Vol.46 (10), p.1803-1806

2003

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Trade space exploration: New Visual Steering features

2010 IEEE Aerospace Conference, 2010, p.1-6

2010

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IEEE_Xplore

Potent antagonists of the Kv1.5 potassium channel: Synthesis and evaluation of analogous N, N-diisopropyl-2-(pyridine-3-yl)acetamides

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5897-5901

2006

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Characterization and Optimization of Pulmonary Function Assessment Methodologies in Restrained Non-rodent Models

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.234-234

2017

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Non-peptide αvβ3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-amino acids as aspartic acid replacements

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (1), p.31-34

2002

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In Vivo Canine Cardiac Electrophysiologic Profile of 1,4-Benzodiazepine Iks Blockers

Journal of cardiovascular pharmacology, 2003-07, Vol.42 (1), p.105-112

2003

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MK-0448, a Specific Kv1.5 Inhibitor: Safety, Pharmacokinetics, and Pharmacodynamic Electrophysiology in Experimental Animal Models and Humans

Circulation. Arrhythmia and electrophysiology, 2012-12, Vol.5 (6), p.1193-1201

2012

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Adding Value to Trade Space Exploration When Designing Complex Engineered Systems

Systems engineering, 2017-03, Vol.20 (2), p.131-146

2017

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EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction

Journal of the American College of Cardiology, 1999-09, Vol.34 (3), p.876-884

1999

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Optimal Continuous-Thrust Trajectories Via Visual Trade Space Exploration

The Journal of the astronautical sciences, 2010-10, Vol.57 (4), p.755-766

2010

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Data on the design and operation of drones by both individuals and teams

Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation

Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics

Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis

Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs

In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide

Block of Peripheral Nerve Sodium Channels Selectively Inhibits Features of Neuropathic Pain in Rats

Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure

Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist

Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists

The Prototype Serotonin 5-HT1B/1D Agonist Sumatriptan Increases the Severity of Myocardial Ischemia During Atrial Pacing in Dogs With Coronary Artery Stenosis

NR2B-Selective N-Methyl-d-aspartate Antagonists: Synthesis and Evaluation of 5-Substituted Benzimidazoles

Orally Efficacious NR2B-Selective NMDA Receptor Antagonists

In Vivo Cardiac Electrophysiologic and Antiarrhythmic Effects of an Isoquinoline IKur Blocker, ISQ-1, in Rat, Dog, and Nonhuman Primate

Decoding the agility of artificial intelligence-assisted human design teams

Benzodiazepines as Potent and Selective Bradykinin B1 Antagonists

Trade space exploration: New Visual Steering features

Potent antagonists of the Kv1.5 potassium channel: Synthesis and evaluation of analogous N, N-diisopropyl-2-(pyridine-3-yl)acetamides

Characterization and Optimization of Pulmonary Function Assessment Methodologies in Restrained Non-rodent Models

Non-peptide αvβ3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-amino acids as aspartic acid replacements

In Vivo Canine Cardiac Electrophysiologic Profile of 1,4-Benzodiazepine Iks Blockers

MK-0448, a Specific Kv1.5 Inhibitor: Safety, Pharmacokinetics, and Pharmacodynamic Electrophysiology in Experimental Animal Models and Humans

Adding Value to Trade Space Exploration When Designing Complex Engineered Systems

EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction

Optimal Continuous-Thrust Trajectories Via Visual Trade Space Exploration

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