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1-Deoxygalactonojirimycin-lysine hybrids as potent d-galactosidase inhibitors

Bioorganic & medicinal chemistry, 2008-12, Vol.16 (24), p.10216-10220

2008

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Synthesis and biological evaluation of novel biotin–iminoalditol conjugates

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (14), p.4077-4079

2010

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A concise synthetic approach for isoiminosugars

Carbohydrate research, 2024-10, Vol.544, p.109239, Article 109239

2024

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Diaminocyclopentane-derived O -GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease

Chemical communications (Cambridge, England), 2022-08, Vol.58 (63), p.8838-8841

2022

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Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study

Chembiochem : a European journal of chemical biology, 2023-12, Vol.24 (23), p.e202300480-e202300480

2023

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Diaminocyclopentane – l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase

Bioorganic chemistry, 2024-07, Vol.148, p.107452-107452, Article 107452

2024

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A remarkable change in inhibition potency and selectivity of isofagomine by simple N-modification

Monatshefte für Chemie, 2024-05

2024

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N‐Methyl‐N‐Alkylaminocyclopentanes: Powerful and Selective β‐d‐Glucocerebrosidase Inhibitors

Helvetica chimica acta, 2024-04, Vol.107 (4), p.n/a

2024

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New α-galactosidase-inhibiting aminohydroxycyclopentanes

RSC advances, 2021-04, Vol.11 (26), p.15943-15951

2021

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Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase

Bioorganic chemistry, 2023-11, Vol.140, p.106819-106819, Article 106819

2023

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Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (3), p.781-786

2012

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Carbohydrate-Processing Enzymes of the Lysosome: Diseases Caused by Misfolded Mutants and Sugar Mimetics as Correcting Pharmacological Chaperones

Advances in carbohydrate chemistry and biochemistry, 2016, Vol.73, p.225

2016

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A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors

Carbohydrate research, 2017-04, Vol.442, p.31-40

2017

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From secondary alcohols to tertiary fluoro substituents: A simple route to hydroxymethyl branched sugars with a fluorine substituent at the branching point

Carbohydrate research, 2016-12, Vol.436, p.11-19

2016

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C-5a-substituted validamine type glycosidase inhibitors

Carbohydrate research, 2017-02, Vol.440-441, p.1-9

2017

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Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.708

2018

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Imino sugars and glycosyl hydrolases: historical context, current aspects, emerging trends

Advances in carbohydrate chemistry and biochemistry, 2011, Vol.66, p.187

2011

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Biologically active branched-chain aminocyclopentane tetraols from d-galactose

Monatshefte für Chemie, 2019-05, Vol.150 (5), p.861-870

2019

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Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful beta -galactosidase inhibitors and low concentration activators of G sub(M1)-gangliosidosis-related human lysosomal beta -galactosidase

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (5), p.1438-1442

2016

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The Amadori rearrangement as glycoconjugation method: Synthesis of non-natural C-glycosyl type glycoconjugates

Beilstein journal of organic chemistry, 2012-09, Vol.8 (1), p.1619-1629

2012

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Fluorous Iminoalditols: A New Family of Glycosidase Inhibitors and Pharmacological Chaperones

Chembiochem : a European journal of chemical biology, 2010-09, Vol.11 (14), p.2026-2033

2010

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A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino- d-galactitol

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6872-6875

2011

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The Structural Basis of Glycosidase Inhibition by Five-Membered Iminocyclitols: The Clan A Glycoside Hydrolase Endoglycoceramidase as a Model System

Angewandte Chemie (International ed.), 2007-01, Vol.46 (24), p.4474-4476

2007

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2-Acetamino-1,2-dideoxynojirimycin—lysine hybrids as hexosaminidase inhibitors

Tetrahedron: asymmetry, 2009-05, Vol.20 (6), p.832-835

2009

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Fluorescent-tagged sp super(2)-iminosugars with potent b-glucosidase inhibitory activity

Bioorganic & medicinal chemistry, 2010-11, Vol.18 (21), p.7439-7445

2010

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1-Deoxygalactonojirimycin-lysine hybrids as potent d-galactosidase inhibitors

Synthesis and biological evaluation of novel biotin–iminoalditol conjugates

A concise synthetic approach for isoiminosugars

Diaminocyclopentane-derived O -GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease

Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study

Diaminocyclopentane – l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase

A remarkable change in inhibition potency and selectivity of isofagomine by simple N-modification

N‐Methyl‐N‐Alkylaminocyclopentanes: Powerful and Selective β‐d‐Glucocerebrosidase Inhibitors

New α-galactosidase-inhibiting aminohydroxycyclopentanes

Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase

Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Carbohydrate-Processing Enzymes of the Lysosome: Diseases Caused by Misfolded Mutants and Sugar Mimetics as Correcting Pharmacological Chaperones

A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors

From secondary alcohols to tertiary fluoro substituents: A simple route to hydroxymethyl branched sugars with a fluorine substituent at the branching point

C-5a-substituted validamine type glycosidase inhibitors

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Imino sugars and glycosyl hydrolases: historical context, current aspects, emerging trends

Biologically active branched-chain aminocyclopentane tetraols from d-galactose

Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful beta -galactosidase inhibitors and low concentration activators of G sub(M1)-gangliosidosis-related human lysosomal beta -galactosidase

The Amadori rearrangement as glycoconjugation method: Synthesis of non-natural C-glycosyl type glycoconjugates

Fluorous Iminoalditols: A New Family of Glycosidase Inhibitors and Pharmacological Chaperones

A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino- d-galactitol

The Structural Basis of Glycosidase Inhibition by Five-Membered Iminocyclitols: The Clan A Glycoside Hydrolase Endoglycoceramidase as a Model System

2-Acetamino-1,2-dideoxynojirimycin—lysine hybrids as hexosaminidase inhibitors

Fluorescent-tagged sp super(2)-iminosugars with potent b-glucosidase inhibitory activity

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