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Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase

Accounts of chemical research, 2013-11, Vol.46 (11), p.2524-2535

2013

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Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex

Science (American Association for the Advancement of Science), 2020-04, Vol.368 (6489), p.424-427

2020

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Class I Ribonucleotide Reductases: Metallocofactor Assembly and Repair In Vitro and In Vivo

Annual review of biochemistry, 2011-01, Vol.80 (1), p.733-767

2011

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Bleomycins: towards better therapeutics

Nature reviews. Cancer, 2005-02, Vol.5 (2), p.102-112

2005

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Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism

Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (39), p.16147-16148

2011

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Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator

The Journal of biological chemistry, 2016-11, Vol.291 (48), p.25264-25277

2016

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Bacillus subtilis Class Ib Ribonucleotide Reductase Is a Dimanganese(III)-Tyrosyl Radical Enzyme

Biochemistry (Easton), 2011-06, Vol.50 (25), p.5615-5623

2011

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Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit

Proceedings of the National Academy of Sciences - PNAS, 2011-06, Vol.108 (24), p.9815-9820

2011

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Conformationally Dynamic Radical Transfer within Ribonucleotide Reductase

Journal of the American Chemical Society, 2017-11, Vol.139 (46), p.16657-16665

2017

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Convergent allostery in ribonucleotide reductase

Nature communications, 2019-06, Vol.10 (1), p.2653-13, Article 2653

2019

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Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2006-08, Vol.361 (1472), p.1351-1364

2006

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An Active Dimanganese(III)−Tyrosyl Radical Cofactor in Escherichia coli Class Ib Ribonucleotide Reductase

Biochemistry (Easton), 2010-02, Vol.49 (6), p.1297-1309

2010

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Radical Initiation in the Class I Ribonucleotide Reductase: Long-Range Proton-Coupled Electron Transfer?

Chemical reviews, 2003-06, Vol.103 (6), p.2167-2202

2003

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Conserved electron donor complex Dre2–Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis

Proceedings of the National Academy of Sciences - PNAS, 2014-04, Vol.111 (17), p.E1695-E1704

2014

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Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage

Nucleic acids research, 2008-06, Vol.36 (11), p.3781-3790

2008

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Structural Basis for Activation of Class Ib Ribonucleotide Reductase

Science (American Association for the Advancement of Science), 2010-09, Vol.329 (5998), p.1526-1530

2010

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Growth and Localization of Polyhydroxybutyrate Granules in Ralstonia eutropha

Journal of Bacteriology, 2012-03, Vol.194 (5), p.1092-1099

2012

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Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (52), p.21046-21051

2011

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Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase

Biochemistry (Easton), 2017-02, Vol.56 (6), p.856-868

2017

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3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

eLife, 2018-02, Vol.7

2018

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A Chemically Competent Thiosulfuranyl Radical on the Escherichia coli Class III Ribonucleotide Reductase

Journal of the American Chemical Society, 2014-06, Vol.136 (25), p.9001-9013

2014

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Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.3835-3840

2013

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Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase

Natural product reports, 2003, Vol.20 (5), p.445

2003

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Ribonucleotide reductase, a novel drug target for gonorrhea

eLife, 2022-02, Vol.11

2022

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Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (36), p.14324-14329

2007

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Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase

Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex

Class I Ribonucleotide Reductases: Metallocofactor Assembly and Repair In Vitro and In Vivo

Bleomycins: towards better therapeutics

Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism

Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator

Bacillus subtilis Class Ib Ribonucleotide Reductase Is a Dimanganese(III)-Tyrosyl Radical Enzyme

Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit

Conformationally Dynamic Radical Transfer within Ribonucleotide Reductase

Convergent allostery in ribonucleotide reductase

Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology

An Active Dimanganese(III)−Tyrosyl Radical Cofactor in Escherichia coli Class Ib Ribonucleotide Reductase

Radical Initiation in the Class I Ribonucleotide Reductase: Long-Range Proton-Coupled Electron Transfer?

Conserved electron donor complex Dre2–Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis

Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage

Structural Basis for Activation of Class Ib Ribonucleotide Reductase

Growth and Localization of Polyhydroxybutyrate Granules in Ralstonia eutropha

Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase

Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

A Chemically Competent Thiosulfuranyl Radical on the Escherichia coli Class III Ribonucleotide Reductase

Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase

Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase

Ribonucleotide reductase, a novel drug target for gonorrhea

Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases

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