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Slide into Action: Dynamic Shuttling of HIV Reverse Transcriptase on Nucleic Acid Substrates

Science (American Association for the Advancement of Science), 2008-11, Vol.322 (5904), p.1092-1097

2008

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Dynamic binding orientations direct activity of HIV reverse transcriptase

Nature, 2008-05, Vol.453 (7192), p.184-189

2008

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Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1

ACS chemical biology, 2019-02, Vol.14 (2), p.223-235

2019

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Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

Journal of the American Chemical Society, 2014-06, Vol.136 (23), p.8402-8410

2014

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Structural characterization of maternally expressed gene 3 RNA reveals conserved motifs and potential sites of interaction with polycomb repressive complex 2

Nucleic acids research, 2018-11, Vol.46 (19), p.10432-10447

2018

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The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication

Nucleic acids research, 2015-05, Vol.43 (9), p.4676-4686

2015

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The Interplay between Myc and CTP Synthase in Drosophila

PLoS genetics, 2016-02, Vol.12 (2), p.e1005867-e1005867

2016

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Characterizing and circumventing sequence restrictions for synthesis of circular RNA in vitro

Nucleic acids research, 2021-04, Vol.49 (6), p.e35-e35

2021

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Motor defects in a Drosophila model for spinal muscular atrophy result from SMN depletion during early neurogenesis

PLoS genetics, 2022-07, Vol.18 (7), p.e1010325-e1010325

2022

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Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity

Molecules (Basel, Switzerland), 2023-09, Vol.28 (18), p.6700

2023

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Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity

Antimicrobial agents and chemotherapy, 2015-02, Vol.59 (2), p.1070-1079

2015

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HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective

Viruses, 2015-06, Vol.7 (6), p.3053-3075

2015

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Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA: a structural scaffold for nuclear, cytoplasmic and viral proteins

Nucleic acids research, 2017-06, Vol.45 (11), p.6805-6821

2017

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Development of Small Molecules with a Noncanonical Binding Mode to HIV‑1 Trans Activation Response (TAR) RNA

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.11148-11160

2016

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Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism

Nucleic acids research, 2015-12, Vol.43 (22), p.11003-11016

2015

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An Unusual Topological Structure of the HIV-1 Rev Response Element

Cell, 2013-10, Vol.155 (3), p.594-605

2013

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DNA binding proteins explore multiple local configurations during docking via rapid rebinding

Nucleic acids research, 2016-09, Vol.44 (17), p.8376-8384

2016

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Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism

PLoS genetics, 2015-03, Vol.11 (3), p.e1004998-e1004998

2015

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Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

PloS one, 2016-01, Vol.11 (1), p.e0147225

2016

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Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome

Nucleic acids research, 2019-06, Vol.47 (11), p.5922-5935

2019

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

The Journal of biological chemistry, 2012-05, Vol.287 (20), p.16801-16811

2012

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Autophagy Deregulation in HIV-1-Infected Cells Increases Extracellular Vesicle Release and Contributes to TLR3 Activation

Viruses, 2024-04, Vol.16 (4), p.643

2024

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Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation

Nature structural & molecular biology, 2013-02, Vol.20 (2), p.230-236

2013

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HIV-1 Transcription Inhibition Using Small RNA-Binding Molecules

Pharmaceuticals (Basel, Switzerland), 2023-12, Vol.17 (1), p.33

2023

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Neurodevelopmental defects as a primer of neurodegeneration: lessons from spinal muscular atrophy and Huntington's disease

Neural regeneration research, 2023-09, Vol.18 (9), p.1952-1953

2023

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Humans
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Human Immunodeficiency Virus 1
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Base Sequence
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Hiv-1 - Enzymology
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Hiv-1 - Genetics
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Molecular Sequence Data
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Aids/hiv
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Human Immunodeficiency Virus
(41)
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(39)
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Slide into Action: Dynamic Shuttling of HIV Reverse Transcriptase on Nucleic Acid Substrates

Dynamic binding orientations direct activity of HIV reverse transcriptase

Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1

Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

Structural characterization of maternally expressed gene 3 RNA reveals conserved motifs and potential sites of interaction with polycomb repressive complex 2

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication

The Interplay between Myc and CTP Synthase in Drosophila

Characterizing and circumventing sequence restrictions for synthesis of circular RNA in vitro

Motor defects in a Drosophila model for spinal muscular atrophy result from SMN depletion during early neurogenesis

Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity

Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity

HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective

Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA: a structural scaffold for nuclear, cytoplasmic and viral proteins

Development of Small Molecules with a Noncanonical Binding Mode to HIV‑1 Trans Activation Response (TAR) RNA

Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism

An Unusual Topological Structure of the HIV-1 Rev Response Element

DNA binding proteins explore multiple local configurations during docking via rapid rebinding

Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

Autophagy Deregulation in HIV-1-Infected Cells Increases Extracellular Vesicle Release and Contributes to TLR3 Activation

Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation

HIV-1 Transcription Inhibition Using Small RNA-Binding Molecules

Neurodevelopmental defects as a primer of neurodegeneration: lessons from spinal muscular atrophy and Huntington's disease

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