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Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update

Experimental gerontology, 2023-06, Vol.176, p.112166-112166, Article 112166

2023

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Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

PloS one, 2011-09, Vol.6 (9), p.e25416

2011

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Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

BMC microbiology, 2019-06, Vol.19 (1), p.130-130, Article 130

2019

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

PloS one, 2010-04, Vol.5 (4), p.e9979

2010

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Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Aging cell, 2014-06, Vol.13 (3), p.468-477

2014

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Nature (London), 2009-07, Vol.460 (7253), p.392-395

2009

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Rapamycin slows aging in mice

Aging cell, 2012-08, Vol.11 (4), p.675-682

2012

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Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

Journal of neurochemistry, 2013-09, Vol.126 (5), p.591-603

2013

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Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson’s diseases

Aging cell, 2019-06, Vol.18 (3), p.e12941-n/a

2019

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Late‐life rapamycin treatment reverses age‐related heart dysfunction

Aging cell, 2013-10, Vol.12 (5), p.851-862

2013

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Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival

Science translational medicine, 2012-07, Vol.4 (144), p.144ra103

2012

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Glycine supplementation extends lifespan of male and female mice

Aging cell, 2019-06, Vol.18 (3), p.e12953-n/a

2019

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Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice

Arthritis research & therapy, 2024-06, Vol.26 (1), p.118-14

2024

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Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease

PloS one, 2012-02, Vol.7 (2), p.e31522

2012

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NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model

EBioMedicine, 2017-07, Vol.21 (C), p.3-4

2017

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WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

The European journal of neuroscience, 2009-06, Vol.29 (11), p.2177-2186

2009

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Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice

Aging cell, 2020-03, Vol.19 (3), p.e13110-n/a

2020

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Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease

PloS one, 2013-08, Vol.8 (8), p.e71341-e71341

2013

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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Aging cell, 2008-10, Vol.7 (5), p.641-650

2008

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Probing the relationship between insulin sensitivity and longevity using genetically modified mice

The journals of gerontology. Series A, Biological sciences and medical sciences, 2012-12, Vol.67 (12), p.1332-1338

2012

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DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease

NPJ Parkinson's Disease, 2023-03, Vol.9 (1), p.42-42, Article 42

2023

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Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease

Brain and behavior, 2023-09, Vol.13 (9), p.e3150-n/a

2023

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Lifespan extension in genetically modified mice

Aging cell, 2009-08, Vol.8 (4), p.346-352

2009

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Dexamethasone Causes Hypertension in Rats Even Under Chemical Blockade of Peripheral Sympathetic Nerves

Frontiers in neuroscience, 2019-12, Vol.13, p.1305-1305

2019

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Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update

Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Rapamycin slows aging in mice

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson’s diseases

Late‐life rapamycin treatment reverses age‐related heart dysfunction

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival

Glycine supplementation extends lifespan of male and female mice

Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice

Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease

NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model

WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice

Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Canagliflozin extends life span in genetically heterogeneous male but not female mice

Probing the relationship between insulin sensitivity and longevity using genetically modified mice

DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease

Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease

Lifespan extension in genetically modified mice

Dexamethasone Causes Hypertension in Rats Even Under Chemical Blockade of Peripheral Sympathetic Nerves

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