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Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy

Journal of controlled release, 2011-09, Vol.154 (3), p.241-248

2011

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iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties

Angewandte Chemie (International ed.), 2016-02, Vol.55 (7), p.2356-2360

International ed. in English, 2016

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Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

European journal of pharmaceutical sciences, 2011-04, Vol.42 (5), p.527-539

2011

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The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel

Journal of controlled release, 2017-01, Vol.246, p.1-11

2017

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HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity

Journal of controlled release, 2012-12, Vol.164 (3), p.346-354

2012

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Interaction of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates with human liver microsomal cytochromes P450: comparison with free doxorubicin

Drug metabolism and disposition, 2011-09, Vol.39 (9), p.1704-1710

2011

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Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data

Journal of controlled release, 2003-08, Vol.91 (1), p.1-16

2003

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Anti-Lymphoma Efficacy Comparison of Anti-Cd20 Monoclonal Antibody-Targeted and Non-Targeted Star-Shaped Polymer-Prodrug Conjugates

Molecules (Basel, Switzerland), 2015-11, Vol.20 (11), p.19849-19864

2015

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Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments

Analytical chemistry (Washington), 2011-07, Vol.83 (13), p.5458-5462

2011

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The Same Drug but a Different Mechanism of Action: Comparison of Free Doxorubicin with Two Different N-(2-Hydroxypropyl)methacrylamide Copolymer-Bound Doxorubicin Conjugates in EL-4 Cancer Cell Line

Bioconjugate chemistry, 2007-05, Vol.18 (3), p.894-902

2007

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Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin

The Journal of biological chemistry, 2000-02, Vol.275 (6), p.3793-3802

2000

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iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties

Angewandte Chemie, 2016-02, Vol.128 (7), p.2402-2406

2016

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Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate

Biomaterials, 2017-01, Vol.115, p.65-80

2017

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HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity

Journal of controlled release, 2009-11, Vol.140 (1), p.18-26

2009

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Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation

European journal of pharmaceutics and biopharmaceutics, 2010-11, Vol.76 (3), p.514-524

2010

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The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia

Journal of controlled release, 2016-02, Vol.223, p.1-10

2016

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HPMA based macromolecular therapeutics: Internalization, intracellular pathway and cell death depend on the character of covalent bond between the drug and the peptidic spacer and also on spacer composition

Journal of drug targeting, 2006-01, Vol.14 (6), p.391-403

2006

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Starlike vs. classic macromolecular prodrugs: Two different antibody-targeted HPMA copolymers of doxorubicin studied in vitro and in vivo as potential anticancer drugs

Pharmaceutical research, 2003-10, Vol.20 (10), p.1558-1564

2003

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Novel IL-2-Poly(HPMA)Nanoconjugate Based Immunotherapy

Journal of biomedical nanotechnology, 2015-09, Vol.11 (9), p.1662-1673

2015

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Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues

Cancer science, 1998-03, Vol.89 (3), p.307-314

1998

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Antitumor activity of IL‐2/anti‐IL‐2 mAb immunocomplexes exerts synergism with that of N‐(2‐hydroxypropyl)methacrylamide copolymer‐bound doxorubicin conjugate due to its low immunosuppressive activity

International journal of cancer, 2011-10, Vol.129 (8), p.2002-2012

2011

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Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice

Cancer Immunology, Immunotherapy, 2007-01, Vol.56 (1), p.35-47

2007

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Star Structure of Antibody-Targeted HPMA Copolymer-Bound Doxorubicin: A Novel Type of Polymeric Conjugate for Targeted Drug Delivery with Potent Antitumor Effect

Bioconjugate chemistry, 2002-03, Vol.13 (2), p.206-215

2002

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Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity

Journal of controlled release, 2005-12, Vol.110 (1), p.119-129

2005

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The pharmacokinetics of polymer-bound adriamycin

Biochemical pharmacology, 1990-03, Vol.39 (6), p.1125-1131

1990

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Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy

iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties

Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel

HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity

Interaction of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates with human liver microsomal cytochromes P450: comparison with free doxorubicin

Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data

Anti-Lymphoma Efficacy Comparison of Anti-Cd20 Monoclonal Antibody-Targeted and Non-Targeted Star-Shaped Polymer-Prodrug Conjugates

Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments

The Same Drug but a Different Mechanism of Action: Comparison of Free Doxorubicin with Two Different N-(2-Hydroxypropyl)methacrylamide Copolymer-Bound Doxorubicin Conjugates in EL-4 Cancer Cell Line

Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin

iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties

Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate

HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity

Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation

The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia

HPMA based macromolecular therapeutics: Internalization, intracellular pathway and cell death depend on the character of covalent bond between the drug and the peptidic spacer and also on spacer composition

Starlike vs. classic macromolecular prodrugs: Two different antibody-targeted HPMA copolymers of doxorubicin studied in vitro and in vivo as potential anticancer drugs

Novel IL-2-Poly(HPMA)Nanoconjugate Based Immunotherapy

Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues

Antitumor activity of IL‐2/anti‐IL‐2 mAb immunocomplexes exerts synergism with that of N‐(2‐hydroxypropyl)methacrylamide copolymer‐bound doxorubicin conjugate due to its low immunosuppressive activity

Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice

Star Structure of Antibody-Targeted HPMA Copolymer-Bound Doxorubicin: A Novel Type of Polymeric Conjugate for Targeted Drug Delivery with Potent Antitumor Effect

Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity

The pharmacokinetics of polymer-bound adriamycin

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