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Antibody-directed Enzyme Prodrug Therapy: Efficacy and Mechanism of Action in Colorectal Carcinoma

Clinical cancer research, 2000-03, Vol.6 (3), p.765

2000

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Enhancement of Antibody-directed enzyme prodrug Therapy in colorectal xenografts by an antivascular agent

Cancer research (Chicago, Ill.), 1999-08, Vol.59 (16), p.3998-4003

1999

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A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy

Nature biotechnology, 1997-12, Vol.15 (13), p.1373-1377

1997

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A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs

British journal of cancer, 2003-05, Vol.88 (10), p.1622-1630

2003

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Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect

Human gene therapy, 2000-01, Vol.11 (2), p.285-292

2000

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Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial

Cancer chemotherapy and pharmacology, 1997, Vol.40 (3), p.189-201

1997

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Identification of key residues involved in mediating the in vivo anti‐tumor/anti‐endothelial activity of Alphastatin

Journal of thrombosis and haemostasis, 2007-04, Vol.5 (4), p.846-854

2007

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Unsymmetrical DNA Cross-Linking Agents: Combination of the CBI and PBD Pharmacophores

Journal of medicinal chemistry, 2003-05, Vol.46 (11), p.2132-2151

2003

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Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models

Cancer research (Chicago, Ill.), 2002-03, Vol.62 (6), p.1724-1729

2002

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Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft

Cancer chemotherapy and pharmacology, 1997, Vol.40 (4), p.277-284

1997

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Current methods for assaying angiogenesis in vitro and in vivo

International journal of experimental pathology, 2004-10, Vol.85 (5), p.233-248

2004

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PC41 THE IN VIVO EFFICACY OF THE ANTIANGIOGENIC PEPTIDE ALPHASTATIN

Microcirculation (New York, N.Y. 1994), 2004-09, Vol.11 (6), p.552-553

2004

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Recent developments in gene-directed enzyme prodrug therapy (GDEPT) for cancer

Current opinion in molecular therapeutics, 1999-08, Vol.1 (4), p.480

1999

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The quantitative determination of photofrin and polyhaematoporphyrin in plasma: pitfalls and inaccuracies

Journal of photochemistry and photobiology. B, Biology, 1995-03, Vol.27 (3), p.209-217

1995

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The cell-line-derived subcutaneous tumor model in preclinical cancer research

Nature protocols, 2022-09, Vol.17 (9), p.2108-2128

2022

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Orthotopic and metastatic tumour models in preclinical cancer research

Pharmacology & therapeutics (Oxford), 2024-05, Vol.257, p.108631-108631, Article 108631

2024

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iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

Journal of cell science, 2022-09, Vol.135 (17)

2022

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Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

EJNMMI research, 2019-02, Vol.9 (1), p.18-13, Article 18

2019

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Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators

Molecular cancer therapeutics, 2009-10, Vol.8 (10), p.2903

2009

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Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure–activity relationships

Bioorganic & medicinal chemistry, 2012-01, Vol.20 (2), p.734-749

2012

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The disposition of allyl isothiocyanate in the rat and mouse

Food and chemical toxicology, 1997-10, Vol.35 (10), p.933-943

1997

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Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1, 2-dihydro-3H-benz[e]indoles; structure―activity relationships: Symposium-in-Print: Chemical Proteomics

Bioorganic & medicinal chemistry, 2012, Vol.20 (2), p.734-749

2012

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Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N 3 DNA minor groove alkylators

Molecular cancer therapeutics, 2009-10, Vol.8 (10), p.2903-2913

2009

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Antibody-directed Enzyme Prodrug Therapy: Efficacy and Mechanism of Action in Colorectal Carcinoma

Enhancement of Antibody-directed enzyme prodrug Therapy in colorectal xenografts by an antivascular agent

A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy

A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs

Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect

Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial

Identification of key residues involved in mediating the in vivo anti‐tumor/anti‐endothelial activity of Alphastatin

Unsymmetrical DNA Cross-Linking Agents: Combination of the CBI and PBD Pharmacophores

Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models

Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft

Current methods for assaying angiogenesis in vitro and in vivo

PC41 THE IN VIVO EFFICACY OF THE ANTIANGIOGENIC PEPTIDE ALPHASTATIN

Recent developments in gene-directed enzyme prodrug therapy (GDEPT) for cancer

The quantitative determination of photofrin and polyhaematoporphyrin in plasma: pitfalls and inaccuracies

The cell-line-derived subcutaneous tumor model in preclinical cancer research

Orthotopic and metastatic tumour models in preclinical cancer research

iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators

Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure–activity relationships

The disposition of allyl isothiocyanate in the rat and mouse

Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1, 2-dihydro-3H-benz[e]indoles; structure―activity relationships: Symposium-in-Print: Chemical Proteomics

Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N 3 DNA minor groove alkylators

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