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Cheminformatic comparison of approved drugs from natural product versus synthetic origins

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (21), p.4802-4807

2015

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A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion

Nature chemical biology, 2012-03, Vol.8 (4), p.358

2012

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Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries

Methods in molecular biology (Clifton, N.J.), 2015-01, Vol.1263, p.225

2015

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Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase from Escherichia coli

The Journal of biological chemistry, 2006-12, Vol.281 (51), p.39285-39293

2006

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Mechanism and Inhibition of saFabI, the Enoyl Reductase from Staphylococcus aureus

Biochemistry (Easton), 2008-04, Vol.47 (14), p.4228-4236

2008

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Niraparib Shows Superior Tissue Distribution and Efficacy in a Prostate Cancer Bone Metastasis Model Compared with Other PARP Inhibitors

Molecular cancer therapeutics, 2022-07, Vol.21 (7), p.1115-1124

2022

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Discovery of Potent and Orally Bioavailable Pyridine N‑Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions

Journal of medicinal chemistry, 2022-08, Vol.65 (15), p.10419-10440

2022

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Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N‑Methyltransferase

ACS chemical biology, 2017-02, Vol.12 (2), p.342-346

2017

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Binding Isotope Effects for Interrogating Enzyme-Substrate Interactions

Methods in enzymology, 2017, Vol.596, p.1

2017

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Transition State Structure and Inhibition of Rv0091, a 5′-Deoxyadenosine/5′-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

ACS chemical biology, 2016-06, Vol.11 (6), p.1669-1676

2016

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Transition State Structure of RNA Depurination by Saporin L3

ACS chemical biology, 2016-05, Vol.11 (5), p.1383-1390

2016

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High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis

ACS chemical biology, 2006-01, Vol.1 (1), p.43-53

2006

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Binding Isotope Effects for para-Aminobenzoic Acid with Dihydropteroate Synthase from Staphylococcus aureus and Plasmodium falciparum

ACS chemical biology, 2015-10, Vol.10 (10), p.2182-2186

2015

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Immucillin-H, a purine nucleoside phosphorylase transition state analog, causes non-lethal attenuation of growth in Staphylococcus aureus

Bioinformation, 2013-01, Vol.9 (1), p.9-17

2013

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Evidence from Raman Spectroscopy That InhA, the Mycobacterial Enoyl Reductase, Modulates the Conformation of the NADH Cofactor to Promote Catalysis

Journal of the American Chemical Society, 2007-05, Vol.129 (20), p.6425-6431

2007

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Abstract 4128: Niraparib shows superior tissue distribution and efficacy in a prostate bone metastasis model compared with other PARP inhibitors

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.4128-4128

2020

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Niraparib Shows Superior Tissue Distribution and Efficacy in a Prostate Cancer Bone Metastasis Model Compared to Other PARP Inhibitors

Molecular cancer therapeutics, 2022-05

2022

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Diversity-oriented synthesis of macrocycles using oxidative ring expansion reactions

Stratton, Christopher F

2012

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Mechanism and Inhibition of saFabI, the Enoyl Reductase from Staphylococcus aureus super([dagger])

Biochemistry (Easton), 2008-01, Vol.47 (14), p.4228-4236

2008

Volltextzugriff (PDF)

Prevalence of BRCA1 and BRCA2 gene Mutations in patients with early-onset breast cancer

JNCI : Journal of the National Cancer Institute, 1999-06, Vol.91 (11), p.943-949

1999

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X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment

Nature genetics, 2008-06, Vol.40 (6), p.776-781

2008

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Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Nature genetics, 2015-03, Vol.47 (3), p.257-262

2015

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Nature genetics, 2007-11, Vol.39 (11), p.1329-1337

2007

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Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

Nature (London), 2013-01, Vol.493 (7432), p.406-410

2013

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Genome-wide association study identifies eight loci associated with blood pressure

Nature genetics, 2009-06, Vol.41 (6), p.666-676

2009

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Cheminformatic comparison of approved drugs from natural product versus synthetic origins

A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion

Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries

Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase from Escherichia coli

Mechanism and Inhibition of saFabI, the Enoyl Reductase from Staphylococcus aureus

Niraparib Shows Superior Tissue Distribution and Efficacy in a Prostate Cancer Bone Metastasis Model Compared with Other PARP Inhibitors

Discovery of Potent and Orally Bioavailable Pyridine N‑Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions

Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N‑Methyltransferase

Binding Isotope Effects for Interrogating Enzyme-Substrate Interactions

Transition State Structure and Inhibition of Rv0091, a 5′-Deoxyadenosine/5′-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

Transition State Structure of RNA Depurination by Saporin L3

High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis

Binding Isotope Effects for para-Aminobenzoic Acid with Dihydropteroate Synthase from Staphylococcus aureus and Plasmodium falciparum

Immucillin-H, a purine nucleoside phosphorylase transition state analog, causes non-lethal attenuation of growth in Staphylococcus aureus

Evidence from Raman Spectroscopy That InhA, the Mycobacterial Enoyl Reductase, Modulates the Conformation of the NADH Cofactor to Promote Catalysis

Abstract 4128: Niraparib shows superior tissue distribution and efficacy in a prostate bone metastasis model compared with other PARP inhibitors

Niraparib Shows Superior Tissue Distribution and Efficacy in a Prostate Cancer Bone Metastasis Model Compared to Other PARP Inhibitors

Diversity-oriented synthesis of macrocycles using oxidative ring expansion reactions

Mechanism and Inhibition of saFabI, the Enoyl Reductase from Staphylococcus aureus super([dagger])

Prevalence of BRCA1 and BRCA2 gene Mutations in patients with early-onset breast cancer

X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

Genome-wide association study identifies eight loci associated with blood pressure

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