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Pharmacokinetics, safety, and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial

Neuro-oncology (Charlottesville, Va.), 2020-12, Vol.22 (12), p.1840-1850

2020

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Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells

Cancer research (Chicago, Ill.), 2018-09, Vol.78 (17), p.5060-5071

2018

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Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter

Developmental cell, 2010-06, Vol.18 (6), p.999-1011

2010

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Confirmed rare copy number variants implicate novel genes in schizophrenia

Biochemical Society transactions, 2010-04, Vol.38 (2), p.445

2010

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Transformed Epithelia Trigger Non-Tissue-Autonomous Tumor Suppressor Response by Adipocytes via Activation of Toll and Eiger/TNF Signaling

Cell reports (Cambridge), 2014-03, Vol.6 (5), p.855-867

2014

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Local Control of Intestinal Stem Cell Homeostasis by Enteroendocrine Cells in the Adult Drosophila Midgut

Current biology, 2014-06, Vol.24 (11), p.1199-1211

2014

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Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase

Molecular oncology, 2015-01, Vol.9 (1), p.192-203

2015

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Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalization via macropinocytosis

Neuro-oncology (Charlottesville, Va.), 2024-04, Vol.26 (4), p.625-639

2024

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Targeting Replication Stress for Glioma Stem Cell Specific Cytotoxicity

Neuro-oncology (Charlottesville, Va.), 2022-10, Vol.24 (Supplement_4), p.iv15-iv15

2022

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Excessive new origin firing underlies selective glioma stem cell cytotoxicity induced by replication stress response inhibition

Neuro-oncology (Charlottesville, Va.), 2021-10, Vol.23 (Supplement_4), p.iv11-iv11

2021

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STEM-22. TARGETING REPLICATION STRESS RESPONSE FOR GLIOMA STEM CELL SPECIFIC CYTOTOXICITY

Neuro-oncology (Charlottesville, Va.), 2021-11, Vol.23 (Supplement_6), p.vi25-vi26

2021

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Glioma Cell Invasion Is Dependent Upon the DNA Damage Response Kinase ATR

Neuro-oncology (Charlottesville, Va.), 2022-10, Vol.24 (Supplement_4), p.iv3-iv3

2022

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CBIO-17. A NOVEL ROLE FOR ATR KINASE DETERMINES GLIOBLASTOMA TUMOUR CELL INVASION

Neuro-oncology (Charlottesville, Va.), 2021-11, Vol.23 (Supplement_6), p.vi30-vi30

2021

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Low-Dose Lung Radiation Therapy for COVID-19 Lung Disease: A Preclinical Efficacy Study in a Bleomycin Model of Pneumonitis

International journal of radiation oncology, biology, physics, 2022-01, Vol.112 (1), p.197-211

2022

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Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics

Cell death and differentiation, 2022-10, Vol.29 (10), p.2089-2104

2022

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Irradiation of glioblastoma cells can promote enhanced motility and invasiveness, both in vitro and in vivo through activation of MRCK

Neuro-oncology (Charlottesville, Va.), 2018-01, Vol.20 (suppl_1), p.i3-i3

2018

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A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Cancer research (Chicago, Ill.), 2018-11, Vol.78 (22), p.6509-6522

2018

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Abstract 1933: A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells in vitro and in vivo

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1933-1933

2018

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Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation

Gut, 2014-03, Vol.63 (3), p.480-493

2014

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CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

Cancer research (Chicago, Ill.), 2016-10, Vol.76 (20), p.6118-6129

2016

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Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

Nature cell biology, 2015-10, Vol.17 (10), p.1317

2015

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The natural history of hepatitis C virus infection: host, viral, and environmental factors

JAMA : the journal of the American Medical Association, 2000-07, Vol.284 (4), p.450

2000

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SynGAP Regulates ERK/MAPK Signaling, Synaptic Plasticity, and Learning in the Complex with Postsynaptic Density 95 and NMDA Receptor

The Journal of neuroscience, 2002-11, Vol.22 (22), p.9721-9732

2002

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TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

Developmental cell, 2013-06, Vol.25 (5), p.463-477

2013

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Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo

Scientific reports, 2017-05, Vol.7 (1), p.1837-9, Article 1837

2017

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Pharmacokinetics, safety, and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial

Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells

Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter

Confirmed rare copy number variants implicate novel genes in schizophrenia

Transformed Epithelia Trigger Non-Tissue-Autonomous Tumor Suppressor Response by Adipocytes via Activation of Toll and Eiger/TNF Signaling

Local Control of Intestinal Stem Cell Homeostasis by Enteroendocrine Cells in the Adult Drosophila Midgut

Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase

Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalization via macropinocytosis

Targeting Replication Stress for Glioma Stem Cell Specific Cytotoxicity

Excessive new origin firing underlies selective glioma stem cell cytotoxicity induced by replication stress response inhibition

STEM-22. TARGETING REPLICATION STRESS RESPONSE FOR GLIOMA STEM CELL SPECIFIC CYTOTOXICITY

Glioma Cell Invasion Is Dependent Upon the DNA Damage Response Kinase ATR

CBIO-17. A NOVEL ROLE FOR ATR KINASE DETERMINES GLIOBLASTOMA TUMOUR CELL INVASION

Low-Dose Lung Radiation Therapy for COVID-19 Lung Disease: A Preclinical Efficacy Study in a Bleomycin Model of Pneumonitis

Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics

Irradiation of glioblastoma cells can promote enhanced motility and invasiveness, both in vitro and in vivo through activation of MRCK

A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Abstract 1933: A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells in vitro and in vivo

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

The natural history of hepatitis C virus infection: host, viral, and environmental factors

SynGAP Regulates ERK/MAPK Signaling, Synaptic Plasticity, and Learning in the Complex with Postsynaptic Density 95 and NMDA Receptor

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo

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