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Native LC–MS for capturing quality attributes of biopharmaceuticals on the intact protein level

Current opinion in biotechnology, 2021-10, Vol.71, p.32-40

2021

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Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells

International journal of molecular sciences, 2021-10, Vol.22 (21), p.11499

2021

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A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

International journal of molecular sciences, 2024-02, Vol.25 (5), p.2785

2024

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CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Advanced science, 2023-12, Vol.10 (35), p.e2302992-n/a

2023

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Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

Journal of pharmaceutical analysis, 2021-12, Vol.11 (6), p.726-731

2021

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In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization

Frontiers in immunology, 2020-08, Vol.11, p.1824

2020

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Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines

iScience, 2023-02, Vol.26 (2), p.105931-105931, Article 105931

2023

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Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality

Frontiers in bioengineering and biotechnology, 2021-04, Vol.9, p.569045-569045

2021

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Fast and efficient digestion of adeno associated virus (AAV) capsid proteins for liquid chromatography mass spectrometry (LC-MS) based peptide mapping and post translational modification analysis (PTMs)

Journal of pharmaceutical and biomedical analysis, 2022-01, Vol.207, p.114427-114427, Article 114427

2022

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Large scale monitoring of a highway bridge with remote sensing and distributed fiber optic techniques during load tests

E-journal of Nondestructive Testing, 2024-07, Vol.29 (7)

2024

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Mass spectrometry friendly pH-gradient anion exchange chromatography for the separation of full and empty adeno-associated virus (AAV) capsids

Analytical methods, 2023-11, Vol.15 (43), p.5788-5792

2023

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Exploring Charge-Detection Mass Spectrometry on Chromatographic Time Scales

Analytical chemistry (Washington), 2023-10, Vol.95 (40), p.15118-15124

2023

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SP3-based host cell protein monitoring in AAV-based gene therapy products using LC-MS/MS

European journal of pharmaceutics and biopharmaceutics, 2023-08, Vol.189, p.276-280

2023

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Detection of host cell microprotein impurities in antibody drug products

Nature communications, 2024-10, Vol.15 (1), p.8605

2024

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A Native Mass Spectrometry-Based Assay for Rapid Assessment of the Empty:Full Capsid Ratio in Adeno-Associated Virus Gene Therapy Products

Analytical chemistry (Washington), 2021-09, Vol.93 (38), p.12817-12821

2021

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Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins

Journal of proteome research, 2023-12, Vol.23 (1), p.161-174

2023

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Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue

Scientific reports, 2020-05, Vol.10 (1), p.7876-7876, Article 7876

2020

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Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS 3 : The Effects of Bioprocessing Conditions on Productivity and Product Quality

Frontiers in bioengineering and biotechnology, 2021, Vol.9, p.569045

2021

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The Power of Freeletics

I-com, 2015-12, Vol.14 (3), p.244-250

2015

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The Power of Freeletics: A Sports Mobile Application through the Lens of Psychological Theory and the User Perspective

I-com, 2015-12, Vol.14 (3), p.244-250

2015

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Steigerung der Reputationskompetenz im betrieblichen Kontext: Einsatzszenarien, Chancen und Grenzen

Online-Reputationskompetenz Von Mitarbeitern, 2019, p.115-131

2019

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Distributed Vibration Monitoring of Bridges with Fiber Optic Sensing Systems

Experimental Vibration Analysis for Civil Engineering Structures, 2023, Vol.433, p.662-671

2023

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Geld allein macht nicht glücklich

Psychologie der Sprichwörter, p.59-66

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Whole-Cell Energy Modeling Reveals Quantitative Changes of Predicted Energy Flows in RAS Mutant Cancer Cell Lines

SSRN Electronic Journal

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Evaluating and selecting arguments in the context of higher order uncertainty

Frontiers in artificial intelligence, 2023-05, Vol.6, p.1133998-1133998

2023

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Native LC–MS for capturing quality attributes of biopharmaceuticals on the intact protein level

Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells

A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization

Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines

Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality

Fast and efficient digestion of adeno associated virus (AAV) capsid proteins for liquid chromatography mass spectrometry (LC-MS) based peptide mapping and post translational modification analysis (PTMs)

Large scale monitoring of a highway bridge with remote sensing and distributed fiber optic techniques during load tests

Mass spectrometry friendly pH-gradient anion exchange chromatography for the separation of full and empty adeno-associated virus (AAV) capsids

Exploring Charge-Detection Mass Spectrometry on Chromatographic Time Scales

SP3-based host cell protein monitoring in AAV-based gene therapy products using LC-MS/MS

Detection of host cell microprotein impurities in antibody drug products

A Native Mass Spectrometry-Based Assay for Rapid Assessment of the Empty:Full Capsid Ratio in Adeno-Associated Virus Gene Therapy Products

Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins

Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue

Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS 3 : The Effects of Bioprocessing Conditions on Productivity and Product Quality

The Power of Freeletics

The Power of Freeletics: A Sports Mobile Application through the Lens of Psychological Theory and the User Perspective

Steigerung der Reputationskompetenz im betrieblichen Kontext: Einsatzszenarien, Chancen und Grenzen

Distributed Vibration Monitoring of Bridges with Fiber Optic Sensing Systems

Geld allein macht nicht glücklich

Whole-Cell Energy Modeling Reveals Quantitative Changes of Predicted Energy Flows in RAS Mutant Cancer Cell Lines

Evaluating and selecting arguments in the context of higher order uncertainty

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