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Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function

The Journal of general physiology, 2018-07, Vol.150 (7), p.1003-1015

2018

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A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel

The Journal of general physiology, 2019-02, Vol.151 (2), p.100-117

2019

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LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology

American Journal of Physiology: Cell Physiology, 2021-03, Vol.320 (3), p.C293-C303

2021

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Cellular volume homeostasis

Advances in physiology education, 2004-12, Vol.28 (4), p.155-159

Strange, Kevin

2004

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Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

eLife, 2023-03, Vol.12

2023

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The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans

Molecular and Cellular Biology, 2009-05, Vol.29 (10), p.2704-2715

2009

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The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK

PLoS genetics, 2016-10, Vol.12 (10), p.e1006361-e1006361

2016

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Hypertonic stress induces rapid and widespread protein damage in C. elegans

American Journal of Physiology: Cell Physiology, 2011-09, Vol.301 (3), p.C566-C576

2011

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Drug Discovery in Fish, Flies, and Worms

ILAR journal, 2016-12, Vol.57 (2), p.133-143

Strange, Kevin

2016

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Genome-Wide RNAi Screening Identifies Protein Damage as a Regulator of Osmoprotective Gene Expression

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (32), p.12173-12178

2006

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The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues

npj Regenerative medicine, 2017-03, Vol.2 (1), p.4-10, Article 4

2017

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Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response

American Journal of Physiology: Cell Physiology, 2008-12, Vol.295 (6), p.C1488-C1498

2008

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Authorship: why not just toss a coin?

American Journal of Physiology: Cell Physiology, 2008-09, Vol.295 (3), p.C567-C575

Strange, Kevin

2008

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Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress

American Journal of Physiology: Cell Physiology, 2005-02, Vol.288 (2), p.C467-C474

2005

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Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans

American Journal of Physiology: Cell Physiology, 2007-09, Vol.293 (3), p.C915-C927

2007

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GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling

American Journal of Physiology: Cell Physiology, 2012-12, Vol.303 (12), p.C1269-C1277

2012

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Putting the pieces together: A crystal clear window into CLC anion channel regulation

Channels (Austin, Tex.), 2011-03, Vol.5 (2), p.101-105

Strange, Kevin

2011

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Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis

PloS one, 2016-04, Vol.11 (4), p.e0154156-e0154156

2016

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Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel

Biophysical journal, 2016-11, Vol.111 (9), p.1876-1886

2016

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Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

Mechanisms of ageing and development, 2009-06, Vol.130 (6), p.357-369

2009

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Functional analysis of the aquaporin gene family in Caenorhabditis elegans

American Journal of Physiology: Cell Physiology, 2007-05, Vol.292 (5), p.C1867-C1873

2007

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Characterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegans

PloS one, 2012-03, Vol.7 (3), p.e34153

2012

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Leucine‐rich repeat containing protein LRRC8A is essential for swelling‐activated Cl− currents and embryonic development in zebrafish

Physiological reports, 2016-10, Vol.4 (19), p.e12940-n/a

2016

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Regulation of Cell Volume in Health and Disease

The New England journal of medicine, 1995-11, Vol.333 (19), p.1260-1267

1995

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A Primary Culture System for Functional Analysis of C. elegans Neurons and Muscle Cells

Neuron (Cambridge, Mass.), 2002-02, Vol.33 (4), p.503-514

2002

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Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function

A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel

LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology

Cellular volume homeostasis

Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans

The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK

Hypertonic stress induces rapid and widespread protein damage in C. elegans

Drug Discovery in Fish, Flies, and Worms

Genome-Wide RNAi Screening Identifies Protein Damage as a Regulator of Osmoprotective Gene Expression

The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues

Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response

Authorship: why not just toss a coin?

Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress

Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans

GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling

Putting the pieces together: A crystal clear window into CLC anion channel regulation

Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis

Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel

Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

Functional analysis of the aquaporin gene family in Caenorhabditis elegans

Characterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegans

Leucine‐rich repeat containing protein LRRC8A is essential for swelling‐activated Cl− currents and embryonic development in zebrafish

Regulation of Cell Volume in Health and Disease

A Primary Culture System for Functional Analysis of C. elegans Neurons and Muscle Cells

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