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Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors

ACS medicinal chemistry letters, 2017-09, Vol.8 (9), p.975-980

2017

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Molecular hybridization yields triazole bronchodilators for the treatment of COPD

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5121-5126

2015

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Nonclassical Zwitterions as a Design Principle to Reduce Lipophilicity without Impacting Permeability

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.9485-9494

2024

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Development of a Scaleable Synthesis of a Geminal Dimethyl Tertiary Amine as an Inhaled Muscarinic Antagonist for the Treatment of COPD

Organic process research & development, 2012-02, Vol.16 (2), p.195-203

2012

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Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.92-96

2010

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Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3404-3406

2011

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Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors

ChemMedChem, 2024-04, Vol.19 (8), p.e202300613-n/a

2024

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Structure-Based and Property-Driven Optimization of N‑Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors

Journal of medicinal chemistry, 2019-12, Vol.62 (23), p.10816-10832

2019

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Front Cover: Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors (ChemMedChem 8/2024)

ChemMedChem, 2024-04, Vol.19 (8), p.n/a

2024

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Abstract PR007: Discovery of HRO761, a novel, first-in-class clinical stage WRN inhibitor with potent and selective anti-tumor activity in cancers with microsatellite instability

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.PR007-PR007

2023

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Orally bioavailable Syk inhibitors with activity in a rat PK/PD model

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (20), p.4642-4647

2015

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Inhalation by Design: Novel Tertiary Amine Muscarinic M3 Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary Disease

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6888-6904

2011

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Multiple drug use: patterns and practices of heroin and crack use in a population of opiate addicts in treatment

Drug and alcohol review, 2001-06, Vol.20 (2), p.201-204

Beswick, David Best, Sian Rees, Ross Coomber, Michael Gossop, John Strang, Tracy

2001

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How the Suboxone Education Programme presented as a solution to risks in the Canadian opioid crisis: a critical discourse analysis

BMJ open, 2022-07, Vol.12 (7), p.e059561-e059561

2022

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Tracking Repeat Victimisation After Domestic Abuse Cases Are Heard With and Without Independent Domestic Violence Advisors (IDVAs) in an English Magistrate’s Court

Cambridge journal of evidence-based policing, 2022-06, Vol.6 (1-2), p.54-68

2022

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Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration—probing the role of PPARα

The FASEB journal, 2019-06, Vol.33 (6), p.7563-7577

2019

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A randomized clinical trial of the effects of brief versus extended opioid overdose education on naloxone utilization outcomes by individuals with opioid use disorder

Drug and alcohol dependence, 2022-08, Vol.237, p.109505-109505, Article 109505

2022

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Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain

Clinical neurophysiology, 2008-09, Vol.119 (9), p.1973-1984

2008

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PPARα-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia

Biochimica et biophysica acta. Molecular basis of disease, 2019-04, Vol.1865 (4), p.844-853

2019

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The Jordan forms of AB and BA

Electronic Journal of Linear Algebra, 2014-11, Vol.27 (1)

2014

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The Palgrave Handbook of Institutional Ethnography

1, 2020

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Investigation of the first cases of human-to-human infection with the new swine-origin influenza A (H1N1) virus in Canada

Canadian Medical Association journal, 2009-08, Vol.181 (3-4), p.159-163

2009

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Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors

Molecular hybridization yields triazole bronchodilators for the treatment of COPD

Nonclassical Zwitterions as a Design Principle to Reduce Lipophilicity without Impacting Permeability

Development of a Scaleable Synthesis of a Geminal Dimethyl Tertiary Amine as an Inhaled Muscarinic Antagonist for the Treatment of COPD

Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor

Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors

Structure-Based and Property-Driven Optimization of N‑Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors

Front Cover: Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors (ChemMedChem 8/2024)

Abstract PR007: Discovery of HRO761, a novel, first-in-class clinical stage WRN inhibitor with potent and selective anti-tumor activity in cancers with microsatellite instability

Orally bioavailable Syk inhibitors with activity in a rat PK/PD model

Inhalation by Design: Novel Tertiary Amine Muscarinic M 3 Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary Disease

Inhalation by Design: Novel Tertiary Amine Muscarinic M3 Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary Disease

Multiple drug use: patterns and practices of heroin and crack use in a population of opiate addicts in treatment

How the Suboxone Education Programme presented as a solution to risks in the Canadian opioid crisis: a critical discourse analysis

Tracking Repeat Victimisation After Domestic Abuse Cases Are Heard With and Without Independent Domestic Violence Advisors (IDVAs) in an English Magistrate’s Court

Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth

Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration—probing the role of PPARα

A randomized clinical trial of the effects of brief versus extended opioid overdose education on naloxone utilization outcomes by individuals with opioid use disorder

Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain

PPARα-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia

The Jordan forms of AB and BA

The Palgrave Handbook of Institutional Ethnography

Investigation of the first cases of human-to-human infection with the new swine-origin influenza A (H1N1) virus in Canada

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