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Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart

Science translational medicine, 2013-10, Vol.5 (207), p.207ra141

2013

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Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and Medicinal Chemistry

Chemical reviews, 2021-02, Vol.121 (3), p.1582-1622

2021

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Total Synthesis of the Kopsia lapidilecta Alkaloid (±)-Lapidilectine B

Journal of organic chemistry, 2004-12, Vol.69 (26), p.9109-9122

2004

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Advances in Lead Generation

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (4), p.517-524

2019

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Fluorous Affinity Purification of Oligonucleotides

Journal of organic chemistry, 2005-09, Vol.70 (18), p.7114-7122

2005

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A Three-Component, One-Pot Synthesis of Indolizidines and Related Heterocycles via the [3+2] Cycloaddition of Nonstabilized Azomethine Ylides

Journal of organic chemistry, 2004-03, Vol.69 (6), p.1919-1939

2004

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Total Synthesis of the Kopsia lapidilecta Alkaloid (±)-Lapidilectine B

Journal of the American Chemical Society, 2001-07, Vol.123 (27), p.6724-6725

2001

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Real-World Treatment Outcomes of Teclistamab Under an Outpatient Model for Step-up Dosing Administration

Blood, 2023-11, Vol.142 (Supplement 1), p.5154-5154

2023

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Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B‑Raf

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.15651-15670

2021

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Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14867-14884

2020

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Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid‑4 (TRPV4)

Journal of medicinal chemistry, 2018-11, Vol.61 (21), p.9738-9755

2018

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Cycloadditions of Nonstabilized2-Azaallyllithiums (2-Azaallyl Anions) and Azomethine Ylides withAlkenes: [3+2] Approaches to Pyrrolidinesand Application to Alkaloid Total Synthesis

Synlett, 2003 (7), p.903-921

2003

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Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo

The Journal of pharmacology and experimental therapeutics, 2021-03, Vol.376 (3), p.436-443

2021

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Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)

ACS medicinal chemistry letters, 2019-08, Vol.10 (8), p.1228-1233

2019

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Cycloadditions of Nonstabilized 2-Azaallyllithiums (2-Azaallyl Anions) and Azomethine Ylides with Alkenes: [3+2] Approaches to Pyrrolidines and Application to Alkaloid Total Synthesis

Synlett, 2003-06, Vol.2003 (7)

2003

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Abstract P280: Deletion of Cardiac Ankyrin Repeat Kinase Reduces Ischemia/Reperfusion Injury in the Heart in Vivo

Circulation research, 2011-12, Vol.109 (suppl_1)

2011

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Azomethine Ylides from Tin-Substituted Cyclic Carbinol Amides: A New Route to Highly Substituted Pyrrolizidines

Organic letters, 2004-03, Vol.6 (6), p.1005-1008

2004

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Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1577-1580

2004

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Improving the developability profile of pyrrolidine progesterone receptor partial agonists

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (1), p.371-374

2010

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Total Synthesis of the Kopsia l apidilecta Alkaloid (±)-Lapidilectine B

Journal of organic chemistry, 2004-12, Vol.69 (26), p.9109-9122

2004

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The Synthesis of 9,10-Dihydro-9,10-(Methaniminomethano)Anthracene and N-Protected Derivatives Via Double Reductive Amination

Synthetic communications, 2004, Vol.34 (19), p.3481-3489

2004

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The discovery of novel, potent and selective PDE5 inhibitors

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (18), p.2461-2464

2001

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I. Completion of the synthesis of Kopsia lapidilecta alkaloid (+/-)-lapidilectine B. II. Synthesis of 1-azabicyclo[n.3.0]alkanes via [3+2] cycloadditions of nonstabilized azomethine ylides

Stoy, Patrick

2004

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Cycloadditions of Nonstabilized 2-Azaallyllithiums (2-Azaallyl Anions) and Azomethine Ylides with Alkenes: [3 + 2] Approaches to Pyrrolidines and Application to Alkaloid Total Synthesis

ChemInform, 2003-09, Vol.34 (35), p.no-no

2003

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Endobronchial Prostheses

Interventions in Pulmonary Medicine, p.213-241

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Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart

Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and Medicinal Chemistry

Total Synthesis of the Kopsia lapidilecta Alkaloid (±)-Lapidilectine B

Advances in Lead Generation

Fluorous Affinity Purification of Oligonucleotides

A Three-Component, One-Pot Synthesis of Indolizidines and Related Heterocycles via the [3+2] Cycloaddition of Nonstabilized Azomethine Ylides

Total Synthesis of the Kopsia lapidilecta Alkaloid (±)-Lapidilectine B

Real-World Treatment Outcomes of Teclistamab Under an Outpatient Model for Step-up Dosing Administration

Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B‑Raf

Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions

Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid‑4 (TRPV4)

Cycloadditions of Nonstabilized2-Azaallyllithiums (2-Azaallyl Anions) and Azomethine Ylides withAlkenes: [3+2] Approaches to Pyrrolidinesand Application to Alkaloid Total Synthesis

Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo

Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)

Cycloadditions of Nonstabilized 2-Azaallyllithiums (2-Azaallyl Anions) and Azomethine Ylides with Alkenes: [3+2] Approaches to Pyrrolidines and Application to Alkaloid Total Synthesis

Abstract P280: Deletion of Cardiac Ankyrin Repeat Kinase Reduces Ischemia/Reperfusion Injury in the Heart in Vivo

Azomethine Ylides from Tin-Substituted Cyclic Carbinol Amides: A New Route to Highly Substituted Pyrrolizidines

Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

Improving the developability profile of pyrrolidine progesterone receptor partial agonists

Total Synthesis of the Kopsia l apidilecta Alkaloid (±)-Lapidilectine B

The Synthesis of 9,10-Dihydro-9,10-(Methaniminomethano)Anthracene and N-Protected Derivatives Via Double Reductive Amination

The discovery of novel, potent and selective PDE5 inhibitors

I. Completion of the synthesis of Kopsia lapidilecta alkaloid (+/-)-lapidilectine B. II. Synthesis of 1-azabicyclo[n.3.0]alkanes via [3+2] cycloadditions of nonstabilized azomethine ylides

Cycloadditions of Nonstabilized 2-Azaallyllithiums (2-Azaallyl Anions) and Azomethine Ylides with Alkenes: [3 + 2] Approaches to Pyrrolidines and Application to Alkaloid Total Synthesis

Endobronchial Prostheses

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