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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Immunity (Cambridge, Mass.), 2016-06, Vol.44 (6), p.1444-1454

2016

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Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies

Frontiers in immunology, 2013-01, Vol.4, p.244-244

2013

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A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)

Oncoimmunology, 2012-09, Vol.1 (6), p.863-873

2012

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A Multiplex Assay for Detection of Staphylococcal and Streptococcal Exotoxins

PloS one, 2015-08, Vol.10 (8), p.e0135986

2015

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TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity

Current opinion in immunology, 2015-04, Vol.33, p.16-22

2015

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Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains

The Journal of immunology (1950), 2018-02, Vol.200 (3), p.1088-1100

2018

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T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

Immunology, 2009-02, Vol.126 (2), p.165-176

2009

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HLA-Restricted Epitope Identification and Detection of Functional T Cell Responses by Using MHC-Peptide and Costimulatory Microarrays

Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (10), p.3744-3749

2005

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ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies

Molecular cancer therapeutics, 2023-08, Vol.22 (8), p.903-912

2023

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T-cell Receptors Engineered De Novo for Peptide Specificity Can Mediate Optimal T-cell Activity without Self Cross-Reactivity

Cancer immunology research, 2019-12, Vol.7 (12), p.2025-2035

2019

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Soluble Peptide-MHC Monomers Cause Activation of CD8+T Cells through Transfer of the Peptide to T Cell MHC Molecules

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (21), p.13729-13734

2002

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Breaking tolerance with engineered class I antigen-presenting molecules

Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (8), p.3136-3145

2019

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A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control

Cancer Immunology, Immunotherapy, 2014-11, Vol.63 (11), p.1163-1176

2014

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The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness

The Journal of immunology (1950), 2009-07, Vol.183 (2), p.1166-1178

2009

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Exploration of the P6/P7 Region of the Peptide-binding Site of the Human Class II Major Histocompatability Complex Protein HLA-DR1

The Journal of biological chemistry, 2003-11, Vol.278 (45), p.44904-44912

2003

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T Cell Receptor Engineering

Methods in Enzymology, 2012, Vol.503, p.189-222

2012

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Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs

The Journal of immunology (1950), 2011-12, Vol.187 (12), p.6281-6290

2011

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Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptor

Biotechnology progress, 2012-11, Vol.28 (6), p.1588-1597

2012

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MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

Cancer Immunology, Immunotherapy, 2013-02, Vol.62 (2), p.359-369

2013

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Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation

The Journal of immunology (1950), 2008-11, Vol.181 (9), p.6255-6264

2008

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Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8

The Journal of immunology (1950), 2011-05, Vol.186 (9), p.5193-5200

2011

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Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display

Methods in molecular biology (Clifton, N.J.), 2009, Vol.504, p.323

2009

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T Cells Use Rafts for Survival

Immunity (Cambridge, Mass.), 2010-02, Vol.32 (2), p.145-147

2010

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Cutting Edge: Inhibitory Effects of CD4 and CD8 on T Cell Activation Induced by High-Affinity Noncognate Ligands

The Journal of immunology (1950), 2009-12, Vol.183 (12), p.7639-7643

2009

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CD8 T Cells, Like CD4 T Cells, Are Triggered by Multivalent Engagement of TCRs by MHC-Peptide Ligands but Not by Monovalent Engagement

Journal of Immunology, 2006-02, Vol.176 (3), p.1498-1505

2006

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Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies

A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)

A Multiplex Assay for Detection of Staphylococcal and Streptococcal Exotoxins

TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

HLA-Restricted Epitope Identification and Detection of Functional T Cell Responses by Using MHC-Peptide and Costimulatory Microarrays

ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies

T-cell Receptors Engineered De Novo for Peptide Specificity Can Mediate Optimal T-cell Activity without Self Cross-Reactivity

Soluble Peptide-MHC Monomers Cause Activation of CD8+T Cells through Transfer of the Peptide to T Cell MHC Molecules

Breaking tolerance with engineered class I antigen-presenting molecules

A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control

The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness

Exploration of the P6/P7 Region of the Peptide-binding Site of the Human Class II Major Histocompatability Complex Protein HLA-DR1

T Cell Receptor Engineering

Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs

Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptor

MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation

Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8

Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display

T Cells Use Rafts for Survival

Cutting Edge: Inhibitory Effects of CD4 and CD8 on T Cell Activation Induced by High-Affinity Noncognate Ligands

CD8 T Cells, Like CD4 T Cells, Are Triggered by Multivalent Engagement of TCRs by MHC-Peptide Ligands but Not by Monovalent Engagement

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