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Sos1 regulates sustained TCR‐mediated Erk activation

European journal of immunology, 2014-05, Vol.44 (5), p.1535-1540

2014

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Critical roles of RasGRP1 for invariant NKT cell development

The Journal of immunology (1950), 2011-11, Vol.187 (9), p.4467-4473

2011

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RasGRPs are targets of the anti-cancer agent ingenol-3-angelate

PloS one, 2013-08, Vol.8 (8), p.e72331-e72331

2013

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RasGRP1 and RasGRP3 Regulate B Cell Proliferation by Facilitating B Cell Receptor-Ras Signaling

Journal of Immunology, 2005-12, Vol.175 (11), p.7179-7184

2005

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Regulation of RasGRP1 function in T cell development and activation by its unique tail domain

PloS one, 2012-06, Vol.7 (6), p.e38796-e38796

2012

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Rap1a Null Mice Have Altered Myeloid Cell Functions Suggesting Distinct Roles for the Closely Related Rap1a and 1b Proteins

The Journal of immunology (1950), 2007-12, Vol.179 (12), p.8322-8331

2007

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Targeted deletion of RasGRP1 impairs skin tumorigenesis

Carcinogenesis (New York), 2014-05, Vol.35 (5), p.1084-1091

2014

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

Nature immunology, 2000-10, Vol.1 (4), p.317-321

2000

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RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4

PloS one, 2013, Vol.8 (1), p.e53300-e53300

2013

Volltextzugriff (PDF)

Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis

The Journal of biological chemistry, 2009-10, Vol.284 (42), p.28522-28532

2009

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A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells

Experimental hematology, 2009, Vol.37 (1), p.122-134.e2

2009

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Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells

Genes & cancer, 2011-03, Vol.2 (3), p.320-334

Stone, James C

2011

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T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α

Nature immunology, 2006-11, Vol.7 (11), p.1166-1173

2006

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Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1

Immunity (Cambridge, Mass.), 2012-05, Vol.36 (5), p.886-886

2012

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TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells

EMBO reports, 2012-04, Vol.13 (4), p.386-391

2012

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RasGRP1 Represents a Novel Non-protein Kinase C Phorbol Ester Signaling Pathway in Mouse Epidermal Keratinocytes

The Journal of biological chemistry, 2003-12, Vol.278 (52), p.52792-52801

2003

Volltextzugriff (PDF)

Differential Requirement of RasGRP1 for gamma delta T Cell Development and Activation

The Journal of immunology (1950), 2012-07, Vol.189 (1), p.61-71

2012

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Genes & development, 1998-10, Vol.12 (19), p.3008-3019

1998

Volltextzugriff (PDF)

Targeted deletion of RasGRP1 impairs skin tumorigenesis

Carcinogenesis (New York), 2014-05, Vol.35 (5), p.1084-1091

2014

Volltextzugriff (PDF)

Differential requirement of RasGRP1 for γδ T cell development and activation

The Journal of immunology (1950), 2012-07, Vol.189 (1), p.61-71

2012

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Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3

Blood, 2003-08, Vol.102 (4), p.1414-1420

2003

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RasGRP, a Ras Guanyl Nucleotide-Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

Science (American Association for the Advancement of Science), 1998-05, Vol.280 (5366), p.1082-1086

1998

Volltextzugriff (PDF)

Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells

Blood, 2005-05, Vol.105 (9), p.3648-3654

2005

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RasGRP1 Transduces Low-Grade TCR Signals which Are Critical for T Cell Development, Homeostasis, and Differentiation

Immunity (Cambridge, Mass.), 2002-11, Vol.17 (5), p.617-627

2002

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RasGRP1 Is Essential for Ras Activation by the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate in Epidermal Keratinocytes

The Journal of biological chemistry, 2010-05, Vol.285 (21), p.15724-15730

2010

Volltextzugriff (PDF)

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Sos1 regulates sustained TCR‐mediated Erk activation

Critical roles of RasGRP1 for invariant NKT cell development

RasGRPs are targets of the anti-cancer agent ingenol-3-angelate

RasGRP1 and RasGRP3 Regulate B Cell Proliferation by Facilitating B Cell Receptor-Ras Signaling

Regulation of RasGRP1 function in T cell development and activation by its unique tail domain

Rap1a Null Mice Have Altered Myeloid Cell Functions Suggesting Distinct Roles for the Closely Related Rap1a and 1b Proteins

Targeted deletion of RasGRP1 impairs skin tumorigenesis

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4

Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis

A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α

Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1

TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells

RasGRP1 Represents a Novel Non-protein Kinase C Phorbol Ester Signaling Pathway in Mouse Epidermal Keratinocytes

Differential Requirement of RasGRP1 for gamma delta T Cell Development and Activation

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Targeted deletion of RasGRP1 impairs skin tumorigenesis

Differential requirement of RasGRP1 for γδ T cell development and activation

Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3

RasGRP, a Ras Guanyl Nucleotide-Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells

RasGRP1 Transduces Low-Grade TCR Signals which Are Critical for T Cell Development, Homeostasis, and Differentiation

RasGRP1 Is Essential for Ras Activation by the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate in Epidermal Keratinocytes

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