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Sugar phosphate activation of the stress sensor eIF2B

Nature communications, 2021-06, Vol.12 (1), p.3440-3440, Article 3440

2021

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Accelerating pharmaceutical structure-guided drug design: a successful model

Drug discovery today, 2019-02, Vol.24 (2), p.377-381

2019

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Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding

Biochimica et biophysica acta, 2016-11, Vol.1860 (11), p.2537-2552

2016

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Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Scientific reports, 2022-08, Vol.12 (1), p.14561-14561, Article 14561

2022

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Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition

Nature communications, 2022-09, Vol.13 (1), p.5500-13, Article 5500

2022

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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.417-429

2021

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Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer

Journal of medicinal chemistry, 2019-04, Vol.62 (8), p.4120-4130

2019

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Author Correction: Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition

Nature communications, 2022-09, Vol.13 (1), p.5694-5694, Article 5694

2022

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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

Molecular cancer therapeutics, 2005-06, Vol.4 (6), p.977-986

2005

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Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe

Scientific reports, 2021-01, Vol.11 (1), p.566-9, Article 566

2021

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Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition

Communications chemistry, 2023-10, Vol.6 (1), p.234-234, Article 234

2023

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Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Communications chemistry, 2024-08, Vol.7 (1), p.183-16

2024

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Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Journal of medicinal chemistry, 2007-04, Vol.50 (7), p.1584-1597

2007

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Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6621-6636

2009

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The journey of macromolecular crystallography in pharmaceutical discovery research at Abbvie and BMS

Acta crystallographica. Section A, Foundations and advances, 2021-07, Vol.77 (a1), p.a19-a19

2021

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Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Chembiochem : a European journal of chemical biology, 2018-03, Vol.19 (6), p.613-621

2018

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Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

Antimicrobial Agents and Chemotherapy, 2005-10, Vol.49 (10), p.4305-4314

2005

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Corrigendum: Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Chembiochem : a European journal of chemical biology, 2018-04, Vol.19 (8), p.890-890

2018

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Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt

Bioorganic & medicinal chemistry, 2007-03, Vol.15 (6), p.2441-2452

2007

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Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.2990-3003

2007

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Buffers: principles and practice

Methods in enzymology, 2009, Vol.463, p.43-56

2009

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A potent erythropoietin-mimicking human antibody interacts through a novel binding site

Blood, 2007-10, Vol.110 (7), p.2408-2413

2007

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Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.612-617

2010

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Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.2000-2007

2006

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Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (11), p.2918-2922

2005

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Sugar phosphate activation of the stress sensor eIF2B

Accelerating pharmaceutical structure-guided drug design: a successful model

Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer

Author Correction: Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe

Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition

Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

The journey of macromolecular crystallography in pharmaceutical discovery research at Abbvie and BMS

Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

Corrigendum: Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt

Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension

Buffers: principles and practice

A potent erythropoietin-mimicking human antibody interacts through a novel binding site

Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket

Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer

Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity

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