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Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11
Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2258-2261
2005
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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1609-1612
2004
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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.654-654
2005
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A convenient cross-coupling route to α,β,γ,δ-unsaturated amino acids
Tetrahedron letters, 1997-02, Vol.38 (8), p.1309-1312
1997
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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole-5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.654-654
2005
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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]- thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole- 5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1609-1612
2004
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Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H, 13H-benzo[b]-thien yl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model
Journal of medicinal chemistry, 2004, Vol.47 (7), p.1609-1612
2004
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Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity
Journal of medicinal chemistry, 2005-09, Vol.48 (18), p.5639-5643
2005
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Novel 1H -(benzimidazol -2 -yl ) -1H -pyridin -2 -one inhibitors of insulin-like growth factor I (IGF-1R) kinase
Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.974-977
2007
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Novel 1@@iH@-(benzimidazol-2-yl)-1@@iH@-pyridin-2-one inhibitors of insulin- like growth factor I (IGF-1R) kinase
Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.974-977
2007
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Novel 1 H-(benzimidazol-2-yl)-1 H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase
Bioorganic & medicinal chemistry letters, 2007, Vol.17 (4), p.974-977
2007
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